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Population heterogeneity is a key factor in epidemic dynamics, influencing both transmission and final epidemic size. While heterogeneity is often modelled through age structure, spatial location, or contact patterns, differences in host…

Populations and Evolution · Quantitative Biology 2026-01-26 Tamás Tekeli , Andrea Pugliese , Cinzia Soresina

In this work, we develop a method to identify continuous-time nonlinear networked dynamics via the Koopman operator framework. The proposed technique consists of two steps: the first step identifies the neighbors of each node, and the…

Systems and Control · Electrical Eng. & Systems 2024-12-25 Ramachandran Anantharaman , Alexandre Mauroy

We consider SISI epidemic model with discrete-time. The crucial point of this model is that an individual can be infected twice. This non-linear evolution operator depends on seven parameters and we assume that the population size under…

Dynamical Systems · Mathematics 2020-08-31 Sobirjon Shoyimardonov

We examine the age-structured SIR model, a variant of the classical Susceptible-Infected-Recovered (SIR) model of epidemic propagation, in the context of COVID-19. In doing so, we provide a theoretical basis for the model, perform an…

Optimization and Control · Mathematics 2022-03-11 Rohit Parasnis , Ryosuke Kato , Amol Sakhale , Massimo Franceschetti , Behrouz Touri

Mathematical models are instrumental to forecast the spread of pathogens and to evaluate the effectiveness of non-pharmaceutical measures. A plethora of optimal strategies has been recently developed to minimize either the infected peak…

Dynamical Systems · Mathematics 2021-11-11 J. Sereno , A. L. Anderson , A. Ferramosca , E. A. Hernandez-Vargas , A. H. Gonzalez

We propose the use of the Extended Kalman Filter (EKF) for online data assimilation and update of a dynamic model, preliminary identified through the Sparse Identification of Nonlinear Dynamics (SINDy). This data-driven technique may avoid…

Dynamical Systems · Mathematics 2024-11-08 Luca Rosafalco , Paolo Conti , Andrea Manzoni , Stefano Mariani , Attilio Frangi

In this manuscript, we develop a mobility-based Susceptible-Infectious-Recovered (SIR) model to elucidate the dynamics of pandemic propagation. While traditional SIR models within the field of epidemiology aptly characterize transitions…

Dynamical Systems · Mathematics 2025-01-16 Ciana Applegate , Jiaxu Li , Dan Han

Increasing number in global COVID-19 cases demands for mathematical model to analyze the interaction between the virus dynamics and the response of innate and adaptive immunity. Here, based on the assumption of a weak and delayed response…

Populations and Evolution · Quantitative Biology 2021-01-13 Zhengqing Zhou , Zhiheng Zhao , Shuyu Shi , Jianghua Wu , Dianjie Li , Jianwei Li , Jingpeng Zhang , Ke Gui , Yu Zhang , Heng Mei , Yu Hu , Qi Ouyang , Fangting Li

The Koopman operator provides a powerful framework for representing the dynamics of general nonlinear dynamical systems. Data-driven techniques to learn the Koopman operator typically assume that the chosen function space is closed under…

Machine Learning · Statistics 2025-02-06 Boya Hou , Sina Sanjari , Nathan Dahlin , Alec Koppel , Subhonmesh Bose

Nonlinearity plays a crucial role in deep neural networks. In this paper, we investigate the degree to which the nonlinearity of the neural network is essential. For this purpose, we employ the Koopman operator, extended dynamic mode…

Machine Learning · Computer Science 2024-07-08 Naoki Sugishita , Kayo Kinjo , Jun Ohkubo

The problems of observability and identifiability have been of great interest as previous steps to estimating parameters and initial conditions of dynamical systems to which some known data (observations) are associated. While most works…

Dynamical Systems · Mathematics 2025-06-16 Alicja B Kubik , Benjamin Ivorra , Alain Rapaport , Ángel M Ramos

In this paper, we propose a novel controller design approach for unknown nonlinear systems using the Koopman operator. In particular, we use the recently proposed stability- and feedback-oriented extended dynamic mode decomposition…

Systems and Control · Electrical Eng. & Systems 2025-09-30 Robin Strässer , Julian Berberich , Frank Allgöwer

We consider an SIR-type (Susceptible $\to$ Infected $\to$ Recovered) stochastic epidemic process with multiple modes of transmission on a contact network. The network is given by a random graph following a multilayer configuration model…

Populations and Evolution · Quantitative Biology 2018-08-22 Karly A. Jacobsen , Mark G. Burch , Joseph H. Tien , Grzegorz A. Rempała

Mixed vehicle platoons, comprising connected and automated vehicles (CAVs) and human-driven vehicles (HDVs), hold significant potential for enhancing traffic performance. However, most existing control strategies assume linear system…

Systems and Control · Electrical Eng. & Systems 2025-11-07 Shuai Li , Jiawei Wang , Kaidi Yang , Qing Xu , Jianqiang Wang , Keqiang Li

This paper develops a parametric Koopman operator framework for Stochastic Model Predictive Control (SMPC), where the Koopman operator is parametrized by Polynomial Chaos Expansions (PCEs). The model is learned from data using the Extended…

Systems and Control · Electrical Eng. & Systems 2026-04-02 Efstathios Iliakis , Wallace Gian Yion Tan , Liang Wu , Jan Drgona , Richard D. Braatz

The role of epidemiological models is crucial for informing public health officials during a public health emergency, such as the COVID-19 pandemic. However, traditional epidemiological models fail to capture the time-varying effects of…

Methodology · Statistics 2022-06-17 Adam Spannaus , Theodore Papamarkou , Samantha Erwin , J. Blair Christian

Deterministic compartmental models are predominantly used in the modeling of infectious diseases, though stochastic models are considered more realistic, yet are complicated to estimate due to missing data. In this paper we present a novel…

Computation · Statistics 2022-06-22 Shuying Wang , Stephen G. Walker

A physics-informed neural network (PINN) embedded with the susceptible-infected-removed (SIR) model is devised to understand the temporal evolution dynamics of infectious diseases. Firstly, the effectiveness of this approach is demonstrated…

Quantitative Methods · Quantitative Biology 2025-04-08 Shuai Han , Lukas Stelz , Horst Stoecker , Lingxiao Wang , Kai Zhou

Current modeling of infectious diseases allows for the study of complex and realistic scenarios that go from the population to the individual level of description. However, most epidemic models assume that the spreading process takes place…

Physics and Society · Physics 2015-04-15 Joaquín Sanz , Cheng-Yi Xia , Sandro Meloni , Yamir Moreno

The Koopman operator provides a powerful framework for representing the dynamics of general nonlinear dynamical systems. However, existing data-driven approaches to learning the Koopman operator rely on batch data. In this work, we present…

Machine Learning · Statistics 2026-04-16 Boya Hou , Sina Sanjari , Nathan Dahlin , Alec Koppel , Subhonmesh Bose
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