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Brain age is the estimate of biological age derived from neuroimaging datasets using machine learning algorithms. Increasing brain age with respect to chronological age can reflect increased vulnerability to neurodegeneration and cognitive…

Quantitative Methods · Quantitative Biology 2024-02-13 Saurabh Sihag , Gonzalo Mateos , Alejandro Ribeiro

Clinical diagnostic workups typically follow a modality escalation pathway: after initial clinical evaluation, clinicians begin with routine structural imaging (e.g., MRI), selectively add sequences such as FLAIR or T2 to refine the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Guangqian Yang , Tong Ding , Wenlong Hou , Yue Xun , Ye Du , Qian Niu , Shujun Wang

The human spine is a complex structure composed of 33 vertebrae. It holds the body and is important for leading a healthy life. The spine is vulnerable to age-related degenerations that can be identified through magnetic resonance imaging…

Deep learning techniques have demonstrated great potential for accurately estimating brain age by analyzing Magnetic Resonance Imaging (MRI) data from healthy individuals. However, current methods for brain age estimation often directly…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Fanzhe Yan , Gang Yang , Yu Li , Aiping Liu , Xun Chen

Brain Age (BA) estimation via Deep Learning has become a strong and reliable bio-marker for brain health, but the black-box nature of Neural Networks does not easily allow insight into the features of brain ageing.We trained a ResNet model…

Neurons and Cognition · Quantitative Biology 2022-07-26 Daniel Taylor , Jonathan Shock , Deshendran Moodley , Jonathan Ipser , Matthias Treder

Accurate brain tumor diagnosis relies on the assessment of multiple Magnetic Resonance Imaging (MRI) sequences. However, in clinical practice, the acquisition of certain sequences may be affected by factors like motion artifacts or contrast…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Moinak Bhattacharya , Saumya Gupta , Annie Singh , Chao Chen , Gagandeep Singh , Prateek Prasanna

Face synthesis, including face aging, in particular, has been one of the major topics that witnessed a substantial improvement in image fidelity by using generative adversarial networks (GANs). Most existing face aging approaches divide the…

Computer Vision and Pattern Recognition · Computer Science 2021-05-04 Zeqi Li , Ruowei Jiang , Parham Aarabi

Background: Regarding the importance of right diagnosis in medical applications, various methods have been exploited for processing medical images solar. The method of segmentation is used to analyze anal to miscall structures in medical…

Image and Video Processing · Electrical Eng. & Systems 2019-07-24 Amir Javadpour , Alireza Mohammadi

Face aging has received continuous research attention over the past two decades. Although previous works on this topic have achieved impressive success, two longstanding problems remain unsettled: 1) generating diverse and plausible facial…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Jiu-Cheng Xie , Jun Yang , Wenqing Wang , Feng Xu , Jiang Xiong , Hao Gao

The ability to accurately recognize an individual's face with respect to human aging factor holds significant importance for various private as well as government sectors such as customs and public security bureaus, passport office, and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Wang Yao , Muhammad Ali Farooq , Joseph Lemley , Peter Corcoran

Advances in AI have introduced several strong models in computational pathology to usher it into the era of multi-modal diagnosis, analysis, and interpretation. However, the current pathology-specific visual language models still lack…

Important applications of advancements in machine learning, are in the area of healthcare, more so for neurological disorder detection. A crucial step towards understanding the neurological status, is to estimate the brain age using…

Image and Video Processing · Electrical Eng. & Systems 2024-07-10 Vamshi Krishna Kancharla , Neelam Sinha

Facial aging is a complex process, highly dependent on multiple factors like gender, ethnicity, lifestyle, etc., making it extremely challenging to learn a global aging prior to predict aging for any individual accurately. Existing…

Computer Vision and Pattern Recognition · Computer Science 2025-08-15 Luchao Qi , Jiaye Wu , Bang Gong , Annie N. Wang , David W. Jacobs , Roni Sengupta

Aging is a highly complex and heterogeneous process that progresses at different rates across individuals, making biological age (BA) a more accurate indicator of physiological decline than chronological age. While previous studies have…

Genomics · Quantitative Biology 2025-10-24 Huifa Li , Feilong Tang , Haochen Xue , Yulong Li , Xinlin Zhuang , Bin Zhang , Eran Segal , Imran Razzak

Brain structural MRI has been widely used to assess the future progression of cognitive impairment (CI). Previous learning-based studies usually suffer from the issue of small-sized labeled training data, while there exist a huge amount of…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Lintao Zhang , Jinjian Wu , Lihong Wang , Li Wang , David C. Steffens , Shijun Qiu , Guy G. Potter , Mingxia Liu

Chronological age of healthy brain is able to be predicted using deep neural networks from T1-weighted magnetic resonance images (T1 MRIs), and the predicted brain age could serve as an effective biomarker for detecting aging-related…

Computer Vision and Pattern Recognition · Computer Science 2022-05-12 Yu Fu , Yanyan Huang , Yalin Wang , Shunjie Dong , Le Xue , Xunzhao Yin , Qianqian Yang , Yiyu Shi , Cheng Zhuo

We present MultiMorph, a fast and efficient method for constructing anatomical atlases on the fly. Atlases capture the canonical structure of a collection of images and are essential for quantifying anatomical variability across…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 S. Mazdak Abulnaga , Andrew Hoopes , Neel Dey , Malte Hoffmann , Marianne Rakic , Bruce Fischl , John Guttag , Adrian Dalca

Given the wide success of convolutional neural networks (CNNs) applied to natural images, researchers have begun to apply them to neuroimaging data. To date, however, exploration of novel CNN architectures tailored to neuroimaging data has…

Computer Vision and Pattern Recognition · Computer Science 2018-08-15 Pascal Sturmfels , Saige Rutherford , Mike Angstadt , Mark Peterson , Chandra Sripada , Jenna Wiens

Neurodegeneration, characterized by the progressive loss of neuronal structure or function, is commonly assessed in clinical practice through reductions in cortical thickness or brain volume, as visualized by structural MRI. While…

Signal Processing · Electrical Eng. & Systems 2025-10-15 Saurabh Sihag , Gonzalo Mateos , Alejandro Ribeiro

Deep learning can provide rapid brain age estimation based on brain magnetic resonance imaging (MRI). However, most studies use one neural network to extract the global information from the whole input image, ignoring the local fine-grained…

Computer Vision and Pattern Recognition · Computer Science 2021-09-14 Sheng He , P. Ellen Grant , Yangming Ou
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