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Large language models (LLMs) are increasingly integrated into high-stakes decision-making. Inspired by the theory of \emph{inattentional blindness} in human cognition, we investigate whether LLMs, trained on human-preferred corpora that…

Computation and Language · Computer Science 2026-05-20 Yuanqing Cai , Ziyi Huang , Minhao Liu , Lixin Duan , Wen Li , Yanru Zhang

Recent studies have demonstrated the feasibility of modeling single-cell data as natural languages and the potential of leveraging powerful large language models (LLMs) for understanding cell biology. However, a comprehensive evaluation of…

Quantitative Methods · Quantitative Biology 2025-05-14 Fan Zhang , Tianyu Liu , Zhihong Zhu , Hao Wu , Haixin Wang , Donghao Zhou , Yefeng Zheng , Kun Wang , Xian Wu , Pheng-Ann Heng

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored…

Computation and Language · Computer Science 2024-07-18 Yanis Labrak , Adrien Bazoge , Emmanuel Morin , Pierre-Antoine Gourraud , Mickael Rouvier , Richard Dufour

Large language models (LLMs) demonstrate their promise in tackling complicated practical challenges by combining action-based policies with chain of thought (CoT) reasoning. Having high-quality prompts on hand, however, is vital to the…

Machine Learning · Computer Science 2024-03-01 Xue Yan , Yan Song , Xinyu Cui , Filippos Christianos , Haifeng Zhang , David Henry Mguni , Jun Wang

Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large…

Computation and Language · Computer Science 2023-11-13 Biqing Qi , Kaiyan Zhang , Haoxiang Li , Kai Tian , Sihang Zeng , Zhang-Ren Chen , Bowen Zhou

Large Language Models (LLMs) have demonstrated remarkable capabilities in complex reasoning tasks, particularly when augmented with search mechanisms that enable systematic exploration of external knowledge bases. The field has evolved from…

Computation and Language · Computer Science 2026-01-27 Yanming Liu , Xinyue Peng , Zixuan Yan , Yanxin Shen , Wenjie Xu , Yuefeng Huang , Xinyi Wang , Jiannan Cao , Jianwei Yin , Xuhong Zhang

While Large Language Models (LLMs) have demonstrated proficiency in handling complex queries, much of the past work has depended on extensively annotated datasets by human experts. However, this reliance on fully-supervised annotations…

Computation and Language · Computer Science 2024-05-08 Yongqi Tong , Sizhe Wang , Dawei Li , Yifan Wang , Simeng Han , Zi Lin , Chengsong Huang , Jiaxin Huang , Jingbo Shang

Effective reasoning remains a core challenge for large language models (LLMs) in the financial domain, where tasks often require domain-specific knowledge, precise numerical calculations, and strict adherence to compliance rules. We propose…

Artificial Intelligence · Computer Science 2025-04-23 Jie Zhu , Qian Chen , Huaixia Dou , Junhui Li , Lifan Guo , Feng Chen , Chi Zhang

Large language models (LLMs) have been widely integrated into information retrieval to advance traditional techniques. However, effectively enabling LLMs to seek accurate knowledge in complex tasks remains a challenge due to the complexity…

Computation and Language · Computer Science 2025-05-27 Zhengliang Shi , Lingyong Yan , Dawei Yin , Suzan Verberne , Maarten de Rijke , Zhaochun Ren

Scientific idea generation is a cornerstone of autonomous knowledge discovery, yet the iterative evolution required to transform initial concepts into high-quality research proposals remains a formidable challenge for Large Language Models…

Artificial Intelligence · Computer Science 2026-03-24 Andreas Sauter , Yuyue Zhao , Jacopo Urbani , Wenxiang Hu , Zaiqiao Meng , Lun Zhou , Xiaohui Yan , Yougang Lyu

This research paper discusses the advances made in the past decade in biomedicine and Large Language Models. To understand how the advances have been made hand-in-hand with one another, the paper also discusses the integration of Natural…

Computation and Language · Computer Science 2024-06-26 Michael Ackerman

Problem-solving has been a fundamental driver of human progress in numerous domains. With advancements in artificial intelligence, Large Language Models (LLMs) have emerged as powerful tools capable of tackling complex problems across…

Machine Learning · Computer Science 2025-05-07 Da Zheng , Lun Du , Junwei Su , Yuchen Tian , Yuqi Zhu , Jintian Zhang , Lanning Wei , Ningyu Zhang , Huajun Chen

Large language models (LLMs) demonstrate remarkable ability to comprehend, reason, and generate following nature language instructions. However, the development of LLMs has been primarily focused on high-resource languages, such as English,…

Large pretrained models are showing increasingly better performance in reasoning and planning tasks across different modalities, opening the possibility to leverage them for complex sequential decision making problems. In this paper, we…

Artificial Intelligence · Computer Science 2024-10-10 Martin Klissarov , Devon Hjelm , Alexander Toshev , Bogdan Mazoure

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

Computation and Language · Computer Science 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

Recent research leverages large language models (LLMs) for early mental health detection, such as depression, often optimized with machine-generated data. However, their detection may be subject to unknown weaknesses. Meanwhile, quality…

Computation and Language · Computer Science 2025-05-26 Zongru Shao , Xin Wang , Zhanyang Liu , Chenhan Wang , K. P. Subbalakshmi

The reasoning capabilities of large language models (LLMs) have advanced rapidly, particularly following the release of DeepSeek R1, which has inspired a surge of research into data quality and reinforcement learning (RL) algorithms.…

Machine Learning · Computer Science 2025-11-04 Jian Yao , Ran Cheng , Xingyu Wu , Jibin Wu , Kay Chen Tan

Recent studies have explored integrating Large Language Models (LLMs) with search engines to leverage both the LLMs' internal pre-trained knowledge and external information. Specially, reinforcement learning (RL) has emerged as a promising…

Artificial Intelligence · Computer Science 2025-12-30 Lang Mei , Zhihan Yang , Xiaohan Yu , Huanyao Zhang , Chong Chen

Large language models (LLMs) have rapidly evolved from text generators into powerful problem solvers. Yet, many open tasks demand critical thinking, multi-source, and verifiable outputs, which are beyond single-shot prompting or standard…

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Computation and Language · Computer Science 2026-03-03 Zhenyu Wang , Zikang Wang , Jiyue Jiang , Pengan Chen , Xiangyu Shi , Yu Li