Related papers: OwkinZero: Accelerating Biological Discovery with …

In recent years, large language models (LLMs) have demonstrated significant potential across various natural language processing (NLP) tasks. However, their performance in domain-specific applications and non-English languages remains less…

Recent Large Reasoning Models (LRMs), such as DeepSeek-R1 and OpenAI o1, have demonstrated strong performance gains by scaling up the length of Chain-of-Thought (CoT) reasoning during inference. However, a growing concern lies in their…

Background: Biomedical entity normalization is critical to biomedical research because the richness of free-text clinical data, such as progress notes, can often be fully leveraged only after translating words and phrases into structured…

The emergence of Large Language Models (LLMs) has fundamentally transformed natural language processing, making them indispensable across domains ranging from conversational systems to scientific exploration. However, their pre-trained…

The current generation of large language models (LLMs) is typically designed for broad, general-purpose applications, while domain-specific LLMs, especially in vertical fields like medicine, remain relatively scarce. In particular, the…

Large Language Models (LLMs) trained via Reinforcement Learning (RL) have recently achieved impressive results on reasoning benchmarks. Yet, growing evidence shows that these models often generate longer but ineffective chains of thought…

Recent advancements in reasoning-focused language models such as OpenAI's O1 and DeepSeek-R1 have shown that scaling test-time computation-through chain-of-thought reasoning and iterative exploration-can yield substantial improvements on…

Molecular discovery, when formulated as an optimization problem, presents significant computational challenges because optimization objectives can be non-differentiable. Evolutionary Algorithms (EAs), often used to optimize black-box…

Large language models (LLMs) have recently demonstrated impressive capabilities across a range of reasoning and generation tasks. However, research studies have shown that LLMs lack the ability to identify causal relationships, a…

Large Language Models (LLMs) have gained enormous attention in recent years due to their capability of understanding and generating natural languages. With the rapid development and wild-range applications (e.g., Agents, Embodied…

Large language models (LLMs) are incredible and versatile tools for text-based tasks that have enabled countless, previously unimaginable, applications. Retrieval models, in contrast, have not yet seen such capable general-purpose models…

Large language models (LLMs) have excelled in various natural language processing tasks, but challenges in interpretability and trustworthiness persist, limiting their use in high-stakes fields. Causal discovery offers a promising approach…

Many real-world scientific and industrial applications require the optimization of expensive black-box functions. Bayesian Optimization (BO) provides an effective framework for such problems. However, traditional BO methods are prone to get…

The performance gap between closed-source and open-source large language models (LLMs) is largely attributed to disparities in access to high-quality training data. To bridge this gap, we introduce a novel framework for the automated…

Large Language Models (LLMs) possess general world knowledge but often struggle to generate precise predictions in structured, domain-specific contexts such as simulations. These limitations arise from their inability to ground their broad,…

Large language models (LLMs) have recently shown strong reasoning abilities in domains like mathematics, coding, and scientific problem-solving, yet their potential for ranking tasks, where prime examples include retrieval, recommender…

Large Language Models (LLMs) have demonstrated remarkable progress in complex reasoning tasks through both post-training and test-time scaling laws. While prevalent test-time scaling approaches are often realized by using external reward…

Large language models (LLMs) excel at general mathematical reasoning but fail catastrophically on specialized technical mathematics. In wireless communications, where problems require precise manipulation of information-theoretic bounds,…

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…