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When evaluating the clinical performance of a medical imaging device, a multi-reader multi-case (MRMC) analysis is usually applied to account for both case and reader variability. For a clinical task that equates to a quantitative…

Quantitative Methods · Quantitative Biology 2021-07-20 Si Wen , Brandon D. Gallas

Agreement coefficients provide a fundamental framework for quantifying the concordance between two or more measurement methods applied to the same continuous variable. Unlike correlation, which measures the strength of a linear…

Methodology · Statistics 2026-04-28 Ronny Vallejos

Reliability is an essential measure of how closely observed scores represent latent scores (reflecting constructs), assuming some latent variable measurement model. We present a general theoretical framework of reliability, placing emphasis…

Methodology · Statistics 2024-10-29 Yang Liu , Jolynn Pek , Alberto Maydeu-Olivares

Assessing agreement between two instruments is crucial in clinical studies to evaluate the similarity between two methods measuring the same subjects. This paper introduces a novel coefficient, termed rho1, to measure agreement between…

Methodology · Statistics 2025-07-11 Ronny Vallejos , Felipe Osorio , Clemente Ferrer

A multi-reader multi-case (MRMC) analysis is applied to account for both reader and case variability when evaluating the clinical performance of a medical imaging device or reader performance under different reading modalities. For a…

Quantitative Methods · Quantitative Biology 2023-12-27 Si Wen , Brandon D. Gallas

A prediction interval covers a future observation from a random process in repeated sampling, and is typically constructed by identifying a pivotal quantity that is also an ancillary statistic. Analogously, a tolerance interval covers a…

Methodology · Statistics 2022-01-19 Geoffrey S Johnson

Human annotation remains the foundation of reliable and interpretable data in Natural Language Processing (NLP). As annotation and evaluation tasks continue to expand, from categorical labelling to segmentation, subjective judgment, and…

Computation and Language · Computer Science 2026-04-02 Joseph James

Ideally, a meta-analysis will summarize data from several unbiased studies. Here we consider the less than ideal situation in which contributing studies may be compromised by measurement error. Measurement error affects every study design,…

The envelope model provides a dimension-reduction framework for multivariate linear regression. However, existing envelope methods typically assume normally distributed random errors and do not accommodate repeated measures in longitudinal…

Methodology · Statistics 2025-12-11 Peng Zeng , Yushan Mu

Linear regression is a frequently used tool in statistics, however, its validity and interpretability relies on strong model assumptions. While robust estimates of the coefficients' covariance extend the validity of hypothesis tests and…

Methodology · Statistics 2015-04-23 Werner Brannath , Martin Scharpenberg

The use of metrics underpins the quantification, communication and, ultimately, the functioning of a wide range of disciplines as diverse as labour recruitment, institutional management, economics and science. For application of metrics,…

Methodology · Statistics 2025-07-03 Luke E. B. Goodyear , Daniel Pincheira-Donoso

There is an increasing number of potential biomarkers that could allow for early assessment of treatment response or disease progression. However, measurements of quantitative biomarkers are subject to random variability. Hence, differences…

Methodology · Statistics 2026-03-02 Moritz Fabian Danzer , Maria Eveslage , Dennis Görlich , Benjamin Noto

Collapsibility deals with the conditions under which a conditional (on a covariate W) measure of association between two random variables X and Y equals the marginal measure of association, under the assumption of homogeneity over the…

Statistics Theory · Mathematics 2011-12-30 P. Vellaisamy

Replicability and reproducibility of experimental results are primary concerns in all the areas of science and IR is not an exception. Besides the problem of moving the field towards more reproducible experimental practices and protocols,…

Information Retrieval · Computer Science 2020-10-27 Timo Breuer , Nicola Ferro , Norbert Fuhr , Maria Maistro , Tetsuya Sakai , Philipp Schaer , Ian Soboroff

As predictive algorithms grow in popularity, using the same dataset to both train and test a new model has become routine across research, policy, and industry. Sample-splitting attains valid inference on model properties by using separate…

Econometrics · Economics 2025-11-27 Bruno Fava

Reproducibility has become an intensely debated topic in NLP and ML over recent years, but no commonly accepted way of assessing reproducibility, let alone quantifying it, has so far emerged. The assumption has been that wider scientific…

Computation and Language · Computer Science 2021-09-06 Anya Belz

Lack of reliability is a well-known issue for reinforcement learning (RL) algorithms. This problem has gained increasing attention in recent years, and efforts to improve it have grown substantially. To aid RL researchers and production…

Machine Learning · Statistics 2020-02-14 Stephanie C. Y. Chan , Samuel Fishman , John Canny , Anoop Korattikara , Sergio Guadarrama

Multiple raters are often needed to be used interchangeably in practice for measurement or evaluation. Assessing agreement among these multiple raters via agreement indices are necessary before their participation. While the intuitively…

Methodology · Statistics 2020-06-09 Tongrong Wang , Huiman X. Barnhart

We introduce the notion of a reproducible algorithm in the context of learning. A reproducible learning algorithm is resilient to variations in its samples -- with high probability, it returns the exact same output when run on two samples…

Machine Learning · Computer Science 2023-04-17 Russell Impagliazzo , Rex Lei , Toniann Pitassi , Jessica Sorrell

To develop rigorous knowledge about ML models -- and the systems in which they are embedded -- we need reliable measurements. But reliable measurement is fundamentally challenging, and touches on issues of reproducibility, scalability,…

Machine Learning · Computer Science 2024-08-13 A. Feder Cooper
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