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Large language models (LLMs) are evolving into agentic systems that reason, plan, and operate external tools. The Model Context Protocol (MCP) is a key enabler of this transition, offering a standardized interface for connecting LLMs with…

Computation and Language · Computer Science 2026-03-06 Xuanjun Zong , Zhiqi Shen , Lei Wang , Yunshi Lan , Chao Yang

By providing a standardized interface for LLM agents to interact with external tools, the Model Context Protocol (MCP) is quickly becoming a cornerstone of the modern autonomous agent ecosystem. However, it creates novel attack surfaces due…

Cryptography and Security · Computer Science 2025-08-22 Zhiqiang Wang , Yichao Gao , Yanting Wang , Suyuan Liu , Haifeng Sun , Haoran Cheng , Guanquan Shi , Haohua Du , Xiangyang Li

Human-AI collaboration faces growing challenges as AI systems increasingly outperform humans on complex tasks, while humans remain responsible for orchestration, validation, and decision oversight. To address this imbalance, we introduce…

Human-Computer Interaction · Computer Science 2026-02-16 Yuanrong Tang , Huiling Peng , Bingxi Zhao , Hengyang Ding , Hanchao Song , Tianhong Wang , Chen Zhong , Jiangtao Gong

The Model Context Protocol (MCP) enables large language models (LLMs) to access external resources on demand. While commonly assumed to enhance performance, how LLMs actually leverage this capability remains poorly understood. We introduce…

Artificial Intelligence · Computer Science 2025-08-19 Wei Song , Haonan Zhong , Ziqi Ding , Jingling Xue , Yuekang Li

Model Context Protocol (MCP) has recently gained increased attention within the AI community for providing a standardized way for large language models (LLMs) to interact with external tools and services, significantly enhancing their…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-12 Zihao Ding , Mufeng Zhu , Yao Liu

Large language models (LLMs) increasingly rely on external tools and APIs to execute complex tasks specified in natural language. Evaluating such tool calling capabilities in realistic enterprise settings is challenging: APIs are often…

Software Engineering · Computer Science 2026-01-27 Benjamin Elder , Anupama Murthi , Jungkoo Kang , Ankita Rajaram Naik , Kiran Kate , Kinjal Basu , Danish Contractor

Model Context Protocols (MCPs) provide a unified platform for agent systems to discover, select, and orchestrate tools across heterogeneous execution environments. As MCP-based systems scale to incorporate larger tool catalogs and multiple…

Cryptography and Security · Computer Science 2026-02-19 Yuval Felendler , Parth A. Gandhi , Idan Habler , Yuval Elovici , Asaf Shabtai

Agentic AI systems built around large language models (LLMs) are moving away from closed, single-model frameworks and toward open ecosystems that connect a variety of agents, external tools, and resources. The Model Context Protocol (MCP)…

Cryptography and Security · Computer Science 2026-02-03 Xinyi Hou , Shenao Wang , Yifan Zhang , Ziluo Xue , Yanjie Zhao , Cai Fu , Haoyu Wang

True intelligence requires active capability acquisition, yet current LLM agents inject pre-defined tool schemas into prompts, reducing models to passive selectors and falling short of robust general-purpose agency. We introduce MCP-Zero,…

Artificial Intelligence · Computer Science 2025-06-25 Xiang Fei , Xiawu Zheng , Hao Feng

Bioinformatics tools are essential for complex computational biology tasks, yet their integration with emerging AI-agent frameworks is hindered by incompatible interfaces, heterogeneous input-output formats, and inconsistent parameter…

Quantitative Methods · Quantitative Biology 2025-10-03 Florensia Widjaja , Zhangtianyi Chen , Juexiao Zhou

Model Context Protocol (MCP) is increasingly adopted for tool-integrated LLM agents, but its multi-layer design and third-party server ecosystem expand risks across tool metadata, untrusted outputs, cross-tool flows, multimodal inputs, and…

Cryptography and Security · Computer Science 2026-04-24 Run Hao , Zhuoran Tan

We present Dynamic ReAct, a novel approach for enabling ReAct agents to efficiently operate with extensive Model Control Protocol (MCP) tool sets that exceed the contextual memory limitations of large language models. Our approach addresses…

Software Engineering · Computer Science 2025-09-29 Nishant Gaurav , Adit Akarsh , Ankit Ranjan , Manoj Bajaj

The Model Context Protocol (MCP) introduces a standard specification that defines how Foundation Model (FM)-based agents should interact with external systems by invoking tools. However, to understand a tool's purpose and features, FMs rely…

Software Engineering · Computer Science 2026-02-24 Mohammed Mehedi Hasan , Hao Li , Gopi Krishnan Rajbahadur , Bram Adams , Ahmed E. Hassan

The Model Context Protocol (MCP) has emerged as a universal standard that enables AI agents to seamlessly connect with external tools, significantly enhancing their functionality. However, while MCP brings notable benefits, it also…

Cryptography and Security · Computer Science 2026-05-26 Yongjian Guo , Puzhuo Liu , Wanlun Ma , Zehang Deng , Xiaogang Zhu , Peng Di , Xi Xiao , Sheng Wen

Large language model (LLM)-based AI agents extend LLM capabilities by enabling access to tools such as data sources, APIs, search engines, code sandboxes, and even other agents. While this empowers agents to perform complex tasks, LLMs may…

Software Engineering · Computer Science 2026-01-14 Aarya Doshi , Yining Hong , Congying Xu , Eunsuk Kang , Alexandros Kapravelos , Christian Kästner

Multi-agent systems represent a significant advancement in artificial intelligence, enabling complex problem-solving through coordinated specialized agents. However, these systems face fundamental challenges in context management,…

Multiagent Systems · Computer Science 2025-05-01 Naveen Krishnan

To reduce development overhead and enable seamless integration between potential components comprising any given generative AI application, the Model Context Protocol (MCP) (Anthropic, 2024) has recently been released and subsequently…

Cryptography and Security · Computer Science 2025-04-14 Brandon Radosevich , John Halloran

Recent advances in LLM Multi-Agent Systems enable scalable orchestration of sub-agents, each coordinating hundreds or thousands of tools or Model Context Protocol (MCP) servers. However, existing retrieval methods typically match queries…

Computation and Language · Computer Science 2025-11-05 Elias Lumer , Faheem Nizar , Anmol Gulati , Pradeep Honaganahalli Basavaraju , Vamse Kumar Subbiah

Large language model (LLM)-powered agents are increasingly used to plan and execute scientific workflows, yet most research cyberinfrastructure (CI) exposes heterogeneous APIs and implements security models that present barriers for use by…

Medical calculators are fundamental to quantitative, evidence-based clinical practice. However, their real-world use is an adaptive, multi-stage process, requiring proactive EHR data acquisition, scenario-dependent calculator selection, and…

Artificial Intelligence · Computer Science 2026-02-02 Yakun Zhu , Yutong Huang , Shengqian Qin , Zhongzhen Huang , Shaoting Zhang , Xiaofan Zhang