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Multiple myeloma is managed through sequential lines of therapy over years to decades, with each decision depending on cumulative disease history distributed across dozens to hundreds of heterogeneous clinical documents. Whether LLM-based…

This paper presents RAG-KG-IL, a novel multi-agent hybrid framework designed to enhance the reasoning capabilities of Large Language Models (LLMs) by integrating Retrieval-Augmented Generation (RAG) and Knowledge Graphs (KGs) with an…

Computation and Language · Computer Science 2025-03-19 Hong Qing Yu , Frank McQuade

Recent advancements in Retrieval-Augmented Generation (RAG) have enabled Large Language Models to answer financial questions using external knowledge bases of U.S. SEC filings, earnings reports, and regulatory documents. However, existing…

Large Language Models (LLMs) are widely used as judges to evaluate response quality, providing a scalable alternative to human evaluation. However, most LLM judges operate solely on intrinsic text-based reasoning, limiting their ability to…

Computation and Language · Computer Science 2026-02-24 Ran Xu , Jingjing Chen , Jiayu Ye , Yu Wu , Jun Yan , Carl Yang , Hongkun Yu

Agent-compiled knowledge bases provide persistent external knowledge for large language model (LLM) agents in open-ended, knowledge-intensive downstream tasks. Yet their quality is systematically limited by \emph{incompleteness},…

Computation and Language · Computer Science 2026-05-12 Haoyu Huang , Jiaxin Bai , Shujie Liu , Yang Wei , Hong Ting Tsang , Yisen Gao , Zhongwei Xie , Yufei Li , Yangqiu Song

Large Language Models (LLMs) have demonstrated significant performance improvements across various cognitive tasks. An emerging application is using LLMs to enhance retrieval-augmented generation (RAG) capabilities. These systems require…

Computation and Language · Computer Science 2025-01-28 Satyapriya Krishna , Kalpesh Krishna , Anhad Mohananey , Steven Schwarcz , Adam Stambler , Shyam Upadhyay , Manaal Faruqui

Next-Generation Sequencing (NGS) has become a cornerstone of genomic research, yet the complexity of downstream analysis-ranging from differential expression gene (DEG) identification to biological interpretations-remains a significant…

Genomics · Quantitative Biology 2025-12-12 Donghyeon Lee , Dongseok Kim , Seokhwan Ko , Seo-Young Park , Junghwan Cho

Reasoning is a fundamental cognitive process that enables logical inference, problem-solving, and decision-making. With the rapid advancement of large language models (LLMs), reasoning has emerged as a key capability that distinguishes…

Retrieval-Augmented Generation (RAG) systems have shown promise in enhancing the performance of Large Language Models (LLMs). However, these systems face challenges in effectively integrating external knowledge with the LLM's internal…

Retrieval-Augmented Generation (RAG) has advanced significantly in recent years. The complexity of RAG systems, which involve multiple components-such as indexing, retrieval, and generation-along with numerous other parameters, poses…

Information Retrieval · Computer Science 2025-08-08 Lorenz Brehme , Thomas Ströhle , Ruth Breu

Large Language Models (LLMs) have been integrated into recommender systems to enhance user behavior comprehension. The Retrieval Augmented Generation (RAG) technique is further incorporated into these systems to retrieve more relevant items…

Information Retrieval · Computer Science 2025-03-27 Sichun Luo , Jian Xu , Xiaojie Zhang , Linrong Wang , Sicong Liu , Hanxu Hou , Linqi Song

Medical vision-language models (VLMs) achieve strong performance in diagnostic reporting and image-text alignment, yet their underlying reasoning mechanisms remain fundamentally correlational, exhibiting reliance on superficial statistical…

Machine Learning · Computer Science 2026-01-27 Weiqin Yang , Haowen Xue , Qingyi Peng , Hexuan Hu , Qian Huang , Tingbo Zhang

The creation of high-quality datasets to improve Large Language Model (LLM) reasoning remains a significant challenge, as current methods often suffer from generating low-quality/incorrect answers and limited information richness from…

Computation and Language · Computer Science 2026-01-09 Xianyang Liu , Yilin Liu , Shuai Wang , Hao Cheng , Andrew Estornell , Yuzhi Zhao , Jun Shu , Jiaheng Wei

Recent advances in the intrinsic reasoning capabilities of large language models (LLMs) have given rise to LLM-based agent systems that exhibit near-human performance on a variety of automated tasks. However, although these systems share…

Artificial Intelligence · Computer Science 2025-08-26 Bingxi Zhao , Lin Geng Foo , Ping Hu , Christian Theobalt , Hossein Rahmani , Jun Liu

Medical Large Vision-Language Models (Med-LVLMs) have shown strong potential in multimodal diagnostic tasks. However, existing single-agent models struggle to generalize across diverse medical specialties, limiting their performance. Recent…

Machine Learning · Computer Science 2026-01-27 Peng Xia , Jinglu Wang , Yibo Peng , Kaide Zeng , Zihan Dong , Xian Wu , Xiangru Tang , Hongtu Zhu , Yun Li , Linjun Zhang , Shujie Liu , Yan Lu , Huaxiu Yao

Recent advances in Large Language Models (LLMs) demonstrate that chain-of-thought prompting and deep reasoning substantially enhance performance on complex tasks, and multi-agent systems can further improve accuracy by enabling model…

Artificial Intelligence · Computer Science 2025-10-16 Zehui Ling , Deshu Chen , Yichi Zhang , Yuchen Liu , Xigui Li , Xin Guo , Yuan Cheng

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Knowing that the generative capabilities of large language models (LLM) are sometimes hampered by tendencies to hallucinate or create non-factual responses, researchers have increasingly focused on methods to ground generated outputs in…

Information Retrieval · Computer Science 2024-11-20 Sonal Prabhune , Donald J. Berndt

Large language models (LLMs) have achieved remarkable progress in complex reasoning tasks, yet they remain fundamentally limited by their reliance on static internal knowledge and text-only reasoning. Real-world problem solving often…

Artificial Intelligence · Computer Science 2025-05-06 Joykirat Singh , Raghav Magazine , Yash Pandya , Akshay Nambi

The deployment of Large Language Models (LLMs) in mental health counseling faces the dual challenges of hallucinations and lack of empathy. While the former may be mitigated by RAG (retrieval-augmented generation) by anchoring answers in…

Computation and Language · Computer Science 2026-01-06 Md Abdullah Al Kafi , Raka Moni , Sumit Kumar Banshal
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