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Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…

Artificial Intelligence · Computer Science 2025-11-18 Bowen Xu , Xinyue Zeng , Jiazhen Hu , Tuo Wang , Adithya Kulkarni

We introduce a novel question-answering (QA) dataset using echocardiogram reports sourced from the Medical Information Mart for Intensive Care database. This dataset is specifically designed to enhance QA systems in cardiology, consisting…

Artificial Intelligence · Computer Science 2025-03-07 Lama Moukheiber , Mira Moukheiber , Dana Moukheiiber , Jae-Woo Ju , Hyung-Chul Lee

We investigate the effectiveness of fine-tuning large language models (LLMs) on small medical datasets for text classification and named entity recognition tasks. Using a German cardiology report dataset and the i2b2 Smoking Challenge…

Computation and Language · Computer Science 2025-03-28 Noah Losch , Lucas Plagwitz , Antonius Büscher , Julian Varghese

An electrocardiogram (ECG) is a widely used, cost-effective tool for detecting electrical abnormalities in the heart. However, it cannot directly measure functional parameters, such as ventricular volumes and ejection fraction, which are…

Image and Video Processing · Electrical Eng. & Systems 2025-06-27 Alexander Selivanov , Philip Müller , Özgün Turgut , Nil Stolt-Ansó , Daniel Rückert

Existing benchmarks for evaluating the clinical reasoning capabilities of large language models (LLMs) often lack a clear definition of "clinical reasoning" as a construct, fail to capture the full breadth of interdependent tasks within a…

Electroencephalogram (EEG) decoding aims to identify the perceptual, semantic, and cognitive content of neural processing based on non-invasively measured brain activity. Traditional EEG decoding methods have achieved moderate success when…

Signal Processing · Electrical Eng. & Systems 2022-03-09 Xun Chen , Chang Li , Aiping Liu , Martin J. McKeown , Ruobing Qian , Z. Jane Wang

Pre-consultation is a critical component of effective healthcare delivery. However, generating comprehensive pre-consultation questionnaires from complex, voluminous Electronic Medical Records (EMRs) is a challenging task. Direct Large…

Artificial Intelligence · Computer Science 2025-08-04 Ruiqing Ding , Qianfang Sun , Yongkang Leng , Hui Yin , Xiaojian Li

The application of Artificial Intelligence (AI) in healthcare has been revolutionary, especially with the recent advancements in transformer-based Large Language Models (LLMs). However, the task of understanding unstructured electronic…

Computation and Language · Computer Science 2023-08-08 Shivani Shekhar , Simran Tiwari , T. C. Rensink , Ramy Eskander , Wael Salloum

Cardiovascular diseases (CVDs) are a group of heart and blood vessel disorders that is one of the most serious dangers to human health, and the number of such patients is still growing. Early and accurate detection plays a key role in…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Khiem H. Le , Hieu H. Pham , Thao BT. Nguyen , Tu A. Nguyen , Tien N. Thanh , Cuong D. Do

Electroencephalogram (EEG) signals are vital for automated seizure detection, but their inherent noise makes robust representation learning challenging. Existing graph construction methods, whether correlation-based or learning-based, often…

Artificial Intelligence · Computer Science 2026-05-01 Lincan Li , Zheng Chen , Yushun Dong

Effective and powerful methods for denoising real electrocardiogram (ECG) signals are important for wearable sensors and devices. Deep Learning (DL) models have been used extensively in image processing and other domains with great success…

Machine Learning · Computer Science 2020-06-24 Corneliu Arsene

Electrocardiogram signals are omnipresent in medicine. A vital aspect in the analysis of this data is the identification and classification of heart beat types which is often done through automated algorithms. Advancements in neural…

Machine Learning · Computer Science 2019-11-13 Tom Van Steenkiste , Dirk Deschrijver , Tom Dhaene

Electrocardiogram (ECG) plays a foundational role in modern cardiovascular care, enabling non-invasive diagnosis of arrhythmias, myocardial ischemia, and conduction disorders. While machine learning has achieved expert-level performance in…

Signal Processing · Electrical Eng. & Systems 2025-07-22 Deyun Zhang , Xiang Lan , Shijia Geng , Qinghao Zhao , Sumei Fan , Mengling Feng , Shenda Hong

This study presents AI-HEART, a cloud-based information system for managing and analysing long-duration ambulatory electrocardiogram (ECG) recordings and supporting clinician decision-making. The platform operationalises an end-to-end…

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

Large language models (LLMs) have achieved remarkable performance on diverse benchmarks, yet existing evaluation practices largely rely on coarse summary metrics that obscure underlying reasoning abilities. In this work, we propose novel…

Methodology · Statistics 2026-03-17 Jia Liu , Zhiyu Xu , Yuqi Gu

Cardiovascular disease is a large worldwide healthcare issue; symptoms often present suddenly with minimal warning. The electrocardiogram (ECG) is a fast, simple and reliable method of evaluating the health of the heart, by measuring…

Signal Processing · Electrical Eng. & Systems 2022-01-15 Yola Jones , Fani Deligianni , Jeff Dalton

Objective: Large Language Models (LLMs) demonstrate significant capabilities in medical text understanding and generation. However, their diagnostic reliability in complex clinical scenarios remains limited. This study aims to enhance LLMs'…

Computation and Language · Computer Science 2025-08-04 Peixian Li , Yu Tian , Ruiqi Tu , Chengkai Wu , Jingjing Ren , Jingsong Li

Cardiovascular events, such as heart attacks and strokes, remain a leading cause of mortality globally, necessitating meticulous monitoring and adjudication in clinical trials. This process, traditionally performed manually by clinical…

Computation and Language · Computer Science 2025-07-01 Sonish Sivarajkumar , Kimia Ameri , Chuqin Li , Yanshan Wang , Min Jiang

Clinicians generally diagnose cardiovascular diseases (CVDs) using standard 12-Lead electrocardiogram (ECG). However, for smartphone-based public healthcare systems, a reduced 3-lead system may be preferred because of (i) increased…

Signal Processing · Electrical Eng. & Systems 2024-10-21 Aditya Mallick , Rahul L R , Albert Shaiju , Satya Deepika Neelapala , Lopamudra Giri , Rahuldeb Sarkar , Soumya Jana