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Clinically significant portal hypertension (CSPH) is a severe complication of chronic liver disease associated with cirrhosis, which is diagnosed by the measurement of hepatic venous pressure gradient (HVPG). However, HVPG measurement is…

Medical Physics · Physics 2021-07-13 Kexin Wang , Shuo Wang , Minghua Xiong , Chengyan Wang , He Wang

Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) $>$ 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary arterial compliance. There are few measurable biomarkers of…

Quantitative Methods · Quantitative Biology 2025-06-06 Amanda L. Colunga , Mitchel J. Colebank , REU Program , Mette S. Olufsen

The local beat-to-beat local pulse pressure (PP) and blood pressure waveform of arteries, especially central arteries, are important indicators of the course of cardiovascular diseases (CVDs). Nevertheless, noninvasive measurement of them…

Signal Processing · Electrical Eng. & Systems 2023-05-30 Lirui Xu , Pang Wu , Pan Xia , Fanglin Geng , Peng Wang , Xianxiang Chen , Zhenfeng Li , Lidong Du , Shuping Liu , Li Li , Hongbo Chang , Zhen Fang

Pulmonary Hypertension (PH) is a severe disease characterized by an elevated pulmonary artery pressure. The gold standard for PH diagnosis is measurement of mean Pulmonary Artery Pressure (mPAP) during an invasive Right Heart…

Image and Video Processing · Electrical Eng. & Systems 2023-12-25 Michal K. Grzeszczyk , Tadeusz Satlawa , Angela Lungu , Andrew Swift , Andrew Narracott , Rod Hose , Tomasz Trzcinski , Arkadiusz Sitek

Accurate noninvasive estimation of intracranial pressure (ICP) remains a major challenge in critical care. We developed a bespoke machine learning algorithm that integrates system identification and ranking-constrained optimization to…

This paper presents a novel blood pressure (BP) estimation method based on pulse transit time (PTT) and pulse arrival time (PAT) to estimate the systolic BP (SBP) and the diastolic BP (DBP). A data acquisition hardware is designed for…

Signal Processing · Electrical Eng. & Systems 2019-05-08 Amirhossein Esmaili , Mohammad Kachuee , Mahdi Shabany

Precise management of patients with cerebral diseases often requires intracranial pressure (ICP) monitoring, which is highly invasive and requires a specialized ICU setting. The ability to noninvasively estimate ICP is highly compelling as…

Medical Physics · Physics 2019-08-27 Jian-Xun Wang , Xiao Hu , Shawn C. Shadden

Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Rene Lisasi , Michele Esposito , Chen Zhao

Echocardiographers can detect pulmonary hypertension using Doppler echocardiography; however, accurately assessing its progression often proves challenging. Right heart catheterization (RHC), the gold standard for precise evaluation, is…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Jiewen Yang , Taoran Huang , Shangwei Ding , Xiaowei Xu , Qinhua Zhao , Yong Jiang , Jiarong Guo , Bin Pu , Jiexuan Zheng , Caojin Zhang , Hongwen Fei , Xiaomeng Li

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

This paper presents a novel approach based on pulse transit time (PTT) for the estimation of blood pressure (BP). In order to achieve this goal, a data acquisition hardware is designed for high-resolution sampling of phonocardiogram (PCG)…

Signal Processing · Electrical Eng. & Systems 2019-05-08 Amirhossein Esmaili , Mohammad Kachuee , Mahdi Shabany

Pancreatic cancer is one of the global leading causes of cancer-related deaths. Despite the success of Deep Learning in computer-aided diagnosis and detection (CAD) methods, little attention has been paid to the detection of Pancreatic…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Christiaan G. A. Viviers , Mark Ramaekers , Peter H. N. de With , Dimitrios Mavroeidis , Joost Nederend , Misha Luyer , Fons van der Sommen

Application of computation in many fields are growing fast in last two decades. Increasing on computation performance helps researchers to understand natural phenomena in many fields of science and technology including in life sciences.…

Biological Physics · Physics 2014-02-27 Suprijadi , Mohamad Rendi , Petrus Subekti , Sparisoma Viridi

Proton Pump Inhibitors (PPIs) are the standard of care for gastric acid disorders but carry significant risks when administered chronically at high doses. Precise long-term control of gastric acidity is challenged by the impracticality of…

Systems and Control · Electrical Eng. & Systems 2025-07-15 Yutong Li , Ilya Kolmanovsky

Extensive research has been performed on continuous, non-invasive, cuffless blood pressure (BP) measurement using artificial intelligence algorithms. This approach involves extracting certain features from physiological signals like ECG,…

Medical Physics · Physics 2023-04-03 Ali Farki , Reza Baradaran Kazemzadeh , Elham Akhondzadeh Noughabi

Exploiting photoplethysmography signals (PPG) for non-invasive blood pressure (BP) measurement is interesting for various reasons. First, PPG can easily be measured using fingerclip sensors. Second, camera-based approaches allow to derive…

Machine Learning · Computer Science 2021-04-20 Fabian Schrumpf , Patrick Frenzel , Christoph Aust , Georg Osterhoff , Mirco Fuchs

Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease that leads to increased pulmonary pressures, vascular remodeling, and eventual right ventricular (RV) failure. Pediatric PAH remains understudied due to limited…

Objective: Our study aimed to evaluate and validate PanSegNet, a deep learning (DL) algorithm for pediatric pancreas segmentation on MRI in children with acute pancreatitis (AP), chronic pancreatitis (CP), and healthy controls. Methods:…

Mean aortic pressure (MAP) is a major determinant of perfusion in all organs systems. The ability to forecast MAP would enhance the ability of physicians to estimate prognosis of the patient and assist in early detection of hemodynamic…

Machine Learning · Computer Science 2020-10-20 Eliza Huang , Rui Wang , Uma Chandrasekaran , Rose Yu

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and sustained hypertension is an often silent risk factor, making cuffless continuous blood pressure (BP) monitoring with wearable devices important for…

Signal Processing · Electrical Eng. & Systems 2025-12-02 Yiqiao Chen , Fazheng Xu , Zijian Huang , Juchi He , Zhenghui Feng
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