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Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Electronic Health Records (EHR) contain rich longitudinal patient information and are widely used in predictive modeling applications. However, effectively leveraging historical data remains challenging due to long trajectories,…

Information Retrieval · Computer Science 2026-05-13 Saeed Shurrab , Mariam Al-Omari , Dana El Samad , Farah E. Shamout

Despite their remarkable capabilities, large language models (LLMs) often produce responses containing factual inaccuracies due to their sole reliance on the parametric knowledge they encapsulate. Retrieval-Augmented Generation (RAG), an ad…

Computation and Language · Computer Science 2023-10-19 Akari Asai , Zeqiu Wu , Yizhong Wang , Avirup Sil , Hannaneh Hajishirzi

Augmenting Large Language Models (LLMs) with information retrieval capabilities (i.e., Retrieval-Augmented Generation (RAG)) has proven beneficial for knowledge-intensive tasks. However, understanding users' contextual search intent when…

Computation and Language · Computer Science 2024-09-25 Nirmal Roy , Leonardo F. R. Ribeiro , Rexhina Blloshmi , Kevin Small

Retrieval Augmented Generation (RAG) has emerged as a widely adopted approach to mitigate the limitations of large language models (LLMs) in answering domain-specific questions. Previous research has predominantly focused on improving the…

Machine Learning · Computer Science 2025-01-07 Mohammad Hassan Heydari , Arshia Hemmat , Erfan Naman , Afsaneh Fatemi

Recent advancements in large language models (LLMs) have enabled their use as agents for planning complex tasks. Existing methods typically rely on a thought-action-observation (TAO) process to enhance LLM performance, but these approaches…

Artificial Intelligence · Computer Science 2025-04-18 Zheng Wang , Shu Xian Teo , Jun Jie Chew , Wei Shi

Medical question answering (QA) is a reasoning-intensive task that remains challenging for large language models (LLMs) due to hallucinations and outdated domain knowledge. Retrieval-Augmented Generation (RAG) provides a promising…

Computation and Language · Computer Science 2025-05-01 Xuanzhao Dong , Wenhui Zhu , Hao Wang , Xiwen Chen , Peijie Qiu , Rui Yin , Yi Su , Yalin Wang

The rapid evolution of mobile edge computing (MEC) has introduced significant challenges in optimizing resource allocation in highly dynamic wireless communication systems, in which task offloading decisions should be made in real-time.…

Signal Processing · Electrical Eng. & Systems 2024-12-31 Runtao Ren , Yinyu Wu , Xuhui Zhang , Jinke Ren , Yanyan Shen , Shuqiang Wang , Kim-Fung Tsang

Retrieval-augmented generation (RAG) enhances large language models (LLMs) by incorporating external knowledge to generate a response within a context with improved accuracy and reduced hallucinations. However, multi-modal RAG systems face…

Machine Learning · Computer Science 2025-01-09 Matin Mortaheb , Mohammad A. Amir Khojastepour , Srimat T. Chakradhar , Sennur Ulukus

Multimodal Retrieval-Augmented Generation (MRAG) enhances large language models (LLMs) by integrating multimodal data (text, images, videos) into retrieval and generation processes, overcoming the limitations of text-only…

Information Retrieval · Computer Science 2025-04-15 Lang Mei , Siyu Mo , Zhihan Yang , Chong Chen

Large Language Models (LLMs) have advanced artificial intelligence by enabling human-like text generation and natural language understanding. However, their reliance on static training data limits their ability to respond to dynamic,…

Artificial Intelligence · Computer Science 2026-04-02 Aditi Singh , Abul Ehtesham , Saket Kumar , Tala Talaei Khoei , Athanasios V. Vasilakos

Large language models (LLMs) struggle with the factual error during inference due to the lack of sufficient training data and the most updated knowledge, leading to the hallucination problem. Retrieval-Augmented Generation (RAG) has gained…

Information Retrieval · Computer Science 2026-01-22 Zulun Zhu , Tiancheng Huang , Kai Wang , Junda Ye , Xinghe Chen , Siqiang Luo

Long-Context Question Answering (LCQA), a challenging task, aims to reason over long-context documents to yield accurate answers to questions. Existing long-context Large Language Models (LLMs) for LCQA often struggle with the "lost in the…

Computation and Language · Computer Science 2024-11-04 Qingfei Zhao , Ruobing Wang , Yukuo Cen , Daren Zha , Shicheng Tan , Yuxiao Dong , Jie Tang

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

Retrieval-augmented generation (RAG) enhances the question-answering (QA) abilities of large language models (LLMs) by integrating external knowledge. However, adapting general-purpose RAG systems to specialized fields such as science and…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hui Liu , Sreyashi Nag , Zhenwei Dai , Yaochen Xie , Xianfeng Tang , Chen Luo , Yang Li , Joyce C. Ho , Carl Yang , Qi He

The conventional Retrieval-Augmented Generation (RAG) paradigm of injecting raw retrieved texts into the Large Language Model (LLM)'s context often results in suboptimal integration of retrieved information. This paper proposes to bridge…

Computation and Language · Computer Science 2026-05-05 Sangkwon Park , Donghun Kang , Jisoo Mok , Sungroh Yoon

Retrieval-Augmented Generation (RAG) enables large language models (LLMs) to access broader knowledge sources, yet factual inconsistencies persist due to noise in retrieved documents-even with advanced retrieval methods. We demonstrate that…

Computation and Language · Computer Science 2025-06-04 Yongjian Li , HaoCheng Chu , Yukun Yan , Zhenghao Liu , Shi Yu , Zheni Zeng , Ruobing Wang , Sen Song , Zhiyuan Liu , Maosong Sun

Retrieval-augmented Generation (RAG) has demonstrated potential in enhancing medical question-answering systems through the integration of large language models (LLMs) with external medical literature. LLMs can retrieve relevant medical…

Computation and Language · Computer Science 2025-10-29 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bin Qin

Large language models (LLMs) achieve optimal utility when their responses are grounded in external knowledge sources. However, real-world documents, such as annual reports, scientific papers, and clinical guidelines, frequently combine…

Information Retrieval · Computer Science 2025-12-17 Chi Zhang , Qiyang Chen , Mengqi Zhang

Large Language Models (LLMs) have demonstrated remarkable capabilities in leveraging extensive external knowledge to enhance responses in multi-turn and agentic applications, such as retrieval-augmented generation (RAG). However, processing…

Computation and Language · Computer Science 2025-10-14 Xiaoqiang Lin , Aritra Ghosh , Bryan Kian Hsiang Low , Anshumali Shrivastava , Vijai Mohan
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