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We developed a positron emission tomography (PET) system for multiple-isotope imaging. Our PET system, named multiple-isotope PET (MI-PET), can distinguish between different tracer nuclides using coincidence measurement of prompt…

Positron Emission Tomography (PET) is an important clinical imaging tool but inevitably introduces radiation hazards to patients and healthcare providers. Reducing the tracer injection dose and eliminating the CT acquisition for attenuation…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Tianqi Chen , Jun Hou , Yinchi Zhou , Huidong Xie , Xiongchao Chen , Qiong Liu , Xueqi Guo , Menghua Xia , James S. Duncan , Chi Liu , Bo Zhou

Accurate attenuation and scatter corrections are crucial in positron emission tomography (PET) imaging for accurate visual interpretation and quantitative analysis. Traditional methods relying on computed tomography (CT) or magnetic…

Medical Physics · Physics 2025-11-14 Min Jeong Cho , Hyeong Seok Shim , Sungyu Kim , Jae Sung Lee

Diffusion-based sparse-view CT (SVCT) imaging has achieved remarkable advancements in recent years, thanks to its more stable generative capability. However, recovering reliable image content and visually consistent textures is still a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Tianqi Wang , Wenchao Du , Hongyu Yang

Positron Emission Tomography (PET) is an essential technique in many clinical applications that allows for quantitative imaging at the molecular level. This study aims to develop a denoising method using novel dilated convolutional neural…

Medical Physics · Physics 2021-01-27 Karl Spuhler , Mario Serrano-Sosa , Renee Cattell , Christine DeLorenzo , Chuan Huang

Objective: Positron Emission Tomography (PET) has been a commonly used imaging modality in broad clinical applications. One of the most important tradeoffs in PET imaging is between image quality and radiation dose: high image quality comes…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Shaoyan Pan , Elham Abouei , Junbo Peng , Joshua Qian , Jacob F Wynne , Tonghe Wang , Chih-Wei Chang , Justin Roper , Jonathon A Nye , Hui Mao , Xiaofeng Yang

Positron range (PR) blurring degrades positron emission tomography (PET) image resolution, particularly for high-energy emitters like gallium-68 (68 Ga). We introduce Dual-Input Dynamic Convolution (DDConv), a novel computationally…

The objective of this study was to develop a PET tumor-segmentation framework that addresses the challenges of limited spatial resolution, high image noise, and lack of clinical training data with ground-truth tumor boundaries in PET…

Photon-counting CT (PCCT) offers improved diagnostic performance through better spatial and energy resolution, but developing high-quality image reconstruction methods that can deal with these large datasets is challenging. Model-based…

Medical Physics · Physics 2022-08-09 Alma Eguizabal , Ozan Öktem , Mats U. Persson

Ultra-low-dose positron emission tomography (PET) reconstruction holds significant potential for reducing patient radiation exposure and shortening examination times. However, it may also lead to increased noise and reduced imaging detail,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Mengxiao Geng , Ran Hong , Bingxuan Li , Qiegen Liu

Recently, spectral CT has been drawing a lot of attention in a variety of clinical applications primarily due to its capability of providing quantitative information about material properties. The quantitative integrity of the reconstructed…

Medical Physics · Physics 2018-01-12 Shiyu Xu , Peter Prinsen , Jens Wiegert , Ravindra Manjeshwar

Our aim was to enhance visual quality and quantitative accuracy of dynamic positron emission tomography (PET)uptake images by improved image reconstruction, using sophisticated sparse penalty models that incorporate both 2D spatial+1D…

Computer Vision and Pattern Recognition · Computer Science 2019-06-17 Ida Häggström , Yizun Lin , Si Li , Andrzej Krol , Yuesheng Xu , C. Ross Schmidtlein

By circumventing the resolution limitations of optics, coherent diffractive imaging (CDI) and ptychography are making their way into scientific fields ranging from X-ray imaging to astronomy. Yet, the need for time consuming iterative phase…

Computational Physics · Physics 2023-10-13 Oliver Hoidn , Aashwin Ananda Mishra , Apurva Mehta

Many spectral CT applications require accurate material decomposition. Existing material decomposition algorithms are often susceptible to significant noise magnification or, in the case of one-step model-based approaches, hampered by slow…

Medical Physics · Physics 2025-07-22 Xiao Jiang , Grace J. Gang , J. Webster Stayman

PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is time-consuming by PET-MRI systems. We aim to accelerate MRI and improve PET image quality. This paper proposed a novel joint…

Computer Vision and Pattern Recognition · Computer Science 2024-08-23 Taofeng Xie , Zhuoxu Cui , Congcong Liu , Chen Luo , Huayu Wang , Yuanzhi Zhang , Xuemei Wang , Yihang Zhou , Qiyu Jin , Guoqing Chen , Dong Liang , Haifeng Wang

Light microscopy is a widespread and inexpensive imaging technique facilitating biomedical discovery and diagnostics. However, light diffraction barrier and imperfections in optics limit the level of detail of the acquired images. The…

Quantitative Methods · Quantitative Biology 2026-03-24 Rui Li , Gabriel della Maggiora , Vardan Andriasyan , Anthony Petkidis , Artsemi Yushkevich , Mikhail Kudryashev , Artur Yakimovich

Magnetic resonance imaging (MRI) and positron emission tomography (PET) are increasingly used in multimodal analysis of neurodegenerative disorders. While MRI is broadly utilized in clinical settings, PET is less accessible. Many studies…

Image and Video Processing · Electrical Eng. & Systems 2024-11-13 Minhui Yu , Mengqi Wu , Ling Yue , Andrea Bozoki , Mingxia Liu

List-mode positron emission tomography (PET) image reconstruction is an important tool for PET scanners with many lines-of-response and additional information such as time-of-flight and depth-of-interaction. Deep learning is one possible…

Medical Physics · Physics 2024-02-13 Kibo Ote , Fumio Hashimoto , Yuya Onishi , Takashi Isobe , Yasuomi Ouchi

Purpose: Neural network image reconstruction directly from measurement data is a relatively new field of research, that until now has been limited to producing small single-slice images (e.g., 1x128x128). This paper proposes a novel and…

Image and Video Processing · Electrical Eng. & Systems 2020-02-13 William Whiteley , Wing K. Luk , Jens Gregor

Attenuation and scatter correction (AC) is crucial for quantitative Positron Emission Tomography (PET) imaging. Recently, direct application of AC in the image domain using deep learning approaches has been proposed for the hybrid PET/MR…

Medical Physics · Physics 2022-06-30 Reza Jahangir , Alireza Kamali-Asl , Hossein Arabi