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Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

Purpose: Recent developments in computational pathology have been driven by advances in Vision Foundation Models, particularly the Segment Anything Model (SAM). This model facilitates nuclei segmentation through two primary methods:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Xueyuan Li , Can Cui , Ruining Deng , Yucheng Tang , Quan Liu , Tianyuan Yao , Shunxing Bao , Naweed Chowdhury , Haichun Yang , Yuankai Huo

Large-scale foundation models have become the mainstream deep learning method, while in civil engineering, the scale of AI models is strictly limited. In this work, a vision foundation model is introduced for crack segmentation. Two…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Kang Ge , Chen Wang , Yutao Guo , Yansong Tang , Zhenzhong Hu , Hongbing Chen

Studying the growth and metabolism of microbes provides critical insights into their evolutionary adaptations to harsh environments, which are essential for microbial research and biotechnology applications. In this study, we developed an…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Shuang Zhang , Carleton Coffin , Karyn L. Rogers , Catherine Ann Royer , Ge Wang

In this paper, we target self-supervised representation learning for zero-shot tumor segmentation. We make the following contributions: First, we advocate a zero-shot setting, where models from pre-training should be directly applicable for…

Computer Vision and Pattern Recognition · Computer Science 2021-12-22 Xiaoman Zhang , Weidi Xie , Chaoqin Huang , Yanfeng Wang , Ya Zhang , Xin Chen , Qi Tian

Tongue segmentation serves as the primary step in automated TCM tongue diagnosis, which plays a significant role in the diagnostic results. Currently, numerous deep learning based methods have achieved promising results. However, when…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Shan Cao , Qunsheng Ruan , Linjian Ma

Automated and semi-automated techniques in biomedical electron microscopy (EM) enable the acquisition of large datasets at a high rate. Segmentation methods are therefore essential to analyze and interpret these large volumes of data, which…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Anusha Aswath , Ahmad Alsahaf , Ben N. G. Giepmans , George Azzopardi

The success of large language models has inspired the computer vision community to explore image segmentation foundation model that is able to zero/few-shot generalize through prompt engineering. Segment-Anything(SAM), among others, is the…

Computer Vision and Pattern Recognition · Computer Science 2024-04-11 Haojie Zhang , Yongyi Su , Xun Xu , Kui Jia

Large foundation models, known for their strong zero-shot generalization capabilities, can be applied to a wide range of downstream tasks. However, developing foundation models for medical image segmentation poses a significant challenge…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Sihan Yang , Jiadong Feng , Xuande Mi , Haixia Bi , Hai Zhang , Jian Sun

In medical image segmentation, heterogeneous privacy policies across institutions often make joint training on pooled datasets infeasible, motivating continual image segmentation-learning from data streams without catastrophic forgetting.…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Jiayi Wang , Wei Dai , Haoyu Wang , Sihan Yang , Haixia Bi , Jian Sun

Image segmentation is a critical enabler for tasks ranging from medical diagnostics to autonomous driving. However, the correct segmentation semantics - where are boundaries located? what segments are logically similar? - change depending…

Nucleus segmentation is an important analysis task in digital pathology. However, methods for automatic segmentation often struggle with new data from a different distribution, requiring users to manually annotate nuclei and retrain…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Titus Griebel , Anwai Archit , Constantin Pape

We consider the problem of accurately identifying cell boundaries and labeling individual cells in confocal microscopy images, specifically, 3D image stacks of cells with tagged cell membranes. Precise identification of cell boundaries,…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Jiaxiang Jiang , Po-Yu Kao , Samuel A. Belteton , Daniel B. Szymanski , B. S. Manjunath

Automated cell segmentation is crucial for various biological and medical applications, facilitating tasks like cell counting, morphology analysis, and drug discovery. However, manual segmentation is time-consuming and prone to…

Machine Learning · Computer Science 2024-09-13 Aaron Rock Menezes , Bharath Ramsundar

The long-tailed distribution problem in medical image analysis reflects a high prevalence of common conditions and a low prevalence of rare ones, which poses a significant challenge in developing a unified model capable of identifying rare…

Computer Vision and Pattern Recognition · Computer Science 2024-03-25 Yankai Jiang , Zhongzhen Huang , Rongzhao Zhang , Xiaofan Zhang , Shaoting Zhang

Deep learning has significantly improved the precision of instance segmentation with abundant labeled data. However, in many areas like medical and manufacturing, collecting sufficient data is extremely hard and labeling this data requires…

Computer Vision and Pattern Recognition · Computer Science 2021-06-02 Ye Zheng , Jiahong Wu , Yongqiang Qin , Faen Zhang , Li Cui

Foundation models have taken over natural language processing and image generation domains due to the flexibility of prompting. With the recent introduction of the Segment Anything Model (SAM), this prompt-driven paradigm has entered image…

Image and Video Processing · Electrical Eng. & Systems 2023-04-13 Saikat Roy , Tassilo Wald , Gregor Koehler , Maximilian R. Rokuss , Nico Disch , Julius Holzschuh , David Zimmerer , Klaus H. Maier-Hein

Accurate segmentation of 3-D cell nuclei in microscopy images is essential for the study of nuclear organization, gene expression, and cell morphodynamics. Current image segmentation methods are challenged by the complexity and variability…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Sundaresh Ram , Jeffrey J. Rodriguez

The Segment Anything Model (SAM) exhibits remarkable versatility and zero-shot learning abilities, owing largely to its extensive training data (SA-1B). Recognizing SAM's dependency on manual guidance given its category-agnostic nature, we…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Xiyu Qi , Yifan Wu , Yongqiang Mao , Wenhui Zhang , Yidan Zhang

Foundation models like SAM (Segment Anything Model) exhibit strong zero-shot image segmentation performance, but often fall short on domain-specific tasks. Fine-tuning these models typically requires significant manual effort and domain…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Breenda Das , Lennart Purucker , Timur Carstensen , Frank Hutter