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Aligning Large Language Models (LLMs) with high-stakes medical standards remains a significant challenge, primarily due to the dissonance between coarse-grained preference signals and the complex, multi-dimensional nature of clinical…

Artificial Intelligence · Computer Science 2026-04-10 He Geng , Yangmin Huang , Lixian Lai , Qianyun Du , Hui Chu , Zhiyang He , Jiaxue Hu , Xiaodong Tao

Large language models (LLMs) show promise for diagnostic reasoning but often lack reliable, knowledge grounded inference. Knowledge graphs (KGs), such as the Unified Medical Language System (UMLS), offer structured biomedical knowledge that…

Computation and Language · Computer Science 2025-09-24 Saksham Khatwani , He Cheng , Majid Afshar , Dmitriy Dligach , Yanjun Gao

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and…

Computation and Language · Computer Science 2024-08-01 Roma Shusterman , Allison C. Waters , Shannon O`Neill , Phan Luu , Don M. Tucker

We introduce MediX-R1, an open-ended Reinforcement Learning (RL) framework for medical multimodal large language models (MLLMs) that enables clinically grounded, free-form answers beyond multiple-choice formats. MediX-R1 fine-tunes a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Sahal Shaji Mullappilly , Mohammed Irfan Kurpath , Omair Mohamed , Mohamed Zidan , Fahad Khan , Salman Khan , Rao Anwer , Hisham Cholakkal

Reinforcement learning (RL) with rule-based reward functions has recently shown great promise in enhancing the reasoning depth and generalization ability of vision-language models (VLMs), while maintaining computational efficiency. In spite…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Yizhou Liu , Dingkang Yang , Zizhi Chen , Minghao Han , Xukun Zhang , Keliang Liu , Jingwei Wei , Lihua Zhang

Prompt engineering significantly influences the reliability and clinical utility of Large Language Models (LLMs) in medical applications. Current optimization approaches inadequately address domain-specific medical knowledge and safety…

Computation and Language · Computer Science 2025-08-26 Yinda Chen , Yangfan He , Jing Yang , Dapeng Zhang , Zhenlong Yuan , Muhammad Attique Khan , Jamel Baili , Por Lip Yee

Users typically engage with LLMs interactively, yet most existing benchmarks evaluate them in a static, single-turn format, posing reliability concerns in interactive scenarios. We identify a key obstacle towards reliability: LLMs are…

Computation and Language · Computer Science 2024-11-08 Shuyue Stella Li , Vidhisha Balachandran , Shangbin Feng , Jonathan S. Ilgen , Emma Pierson , Pang Wei Koh , Yulia Tsvetkov

The integration of large language models (LLMs) and search engines represents a significant evolution in knowledge acquisition methodologies. However, determining the knowledge that an LLM already possesses and the knowledge that requires…

Computation and Language · Computer Science 2024-05-31 Jiejun Tan , Zhicheng Dou , Yutao Zhu , Peidong Guo , Kun Fang , Ji-Rong Wen

We present a framework for training large language models (LLMs) as diagnostic agents with reinforcement learning, enabling them to manage multi-turn interactive diagnostic processes, adaptively select examinations, and commit to final…

Computation and Language · Computer Science 2026-02-11 Pengcheng Qiu , Chaoyi Wu , Junwei Liu , Qiaoyu Zheng , Yusheng Liao , Haowen Wang , Yun Yue , Qianrui Fan , Shuai Zhen , Jian Wang , Jinjie Gu , Yanfeng Wang , Ya Zhang , Weidi Xie

Medical consultations are intrinsically speech-centric. However, most prior works focus on long-text-based interactions, which are cumbersome and patient-unfriendly. Recent advances in speech language models (SpeechLMs) have enabled more…

Computation and Language · Computer Science 2026-04-21 Sirry Chen , Jieyi Wang , Wei Chen , Zhongyu Wei

Reinforcement Learning (RL) traditionally relies on scalar reward signals, limiting its ability to leverage the rich semantic knowledge often available in real-world tasks. In contrast, humans learn efficiently by combining numerical…

Large Language models (LLMs) possess the capability to engage In-context Learning (ICL) by leveraging a few demonstrations pertaining to a new downstream task as conditions. However, this particular learning paradigm suffers from high…

Computation and Language · Computer Science 2023-10-16 Hongfu Liu , Ye Wang

Large language models (LLMs) have recently demonstrated their impressive ability to provide context-aware responses via text. This ability could potentially be used to predict plausible solutions in sequential decision making tasks…

Artificial Intelligence · Computer Science 2023-08-29 Thommen George Karimpanal , Laknath Buddhika Semage , Santu Rana , Hung Le , Truyen Tran , Sunil Gupta , Svetha Venkatesh

Psychological consultation is essential for improving mental health and well-being, yet challenges such as the shortage of qualified professionals and scalability issues limit its accessibility. To address these challenges, we explore the…

Computation and Language · Computer Science 2024-08-30 Rafael Souza , Jia-Hao Lim , Alexander Davis

The adoption of large language models (LLMs) in healthcare has attracted significant research interest. However, their performance in healthcare remains under-investigated and potentially limited, due to i) they lack rich domain-specific…

Artificial Intelligence · Computer Science 2024-05-21 Zishan Gu , Fenglin Liu , Changchang Yin , Ping Zhang

Large language models (LLMs) have demonstrated impressive success in a wide range of natural language processing (NLP) tasks due to their extensive general knowledge of the world. Recent works discovered that the performance of LLMs is…

Computation and Language · Computer Science 2024-11-25 Yuze Liu , Tingjie Liu , Tiehua Zhang , Youhua Xia , Jinze Wang , Zhishu Shen , Jiong Jin , Fei Richard Yu

Speech large language models (LLMs) observe paralinguistic cues such as prosody, emotion, and non-verbal sounds--crucial for intent understanding. However, leveraging these cues faces challenges: limited training data, annotation…

Our team participated in the BioASQ 2024 Task12b and Synergy tasks to build a system that can answer biomedical questions by retrieving relevant articles and snippets from the PubMed database and generating exact and ideal answers. We…

Computation and Language · Computer Science 2024-07-10 Wenxin Zhou , Thuy Hang Ngo

Reranking is fundamental to information retrieval and retrieval-augmented generation, with recent Large Language Models (LLMs) significantly advancing reranking quality. Most current works rely on large-scale LLMs (>7B parameters),…

Information Retrieval · Computer Science 2026-04-17 Xianming Li , Aamir Shakir , Rui Huang , Tsz-fung Andrew Lee , Julius Lipp , Benjamin Clavié , Jing Li

We present Information Gain Fine-Tuning (IGFT), a novel approach for training medical conversational AI to conduct effective patient interviews and generate comprehensive History of Present Illness (HPI) without requiring pre-collected…

Artificial Intelligence · Computer Science 2026-01-27 Tanvi Verma , Yang Zhou , Rick Siow Mong Goh , Yong Liu
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