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Vision-language models (VLMs) have shown strong promise for medical image analysis, but most remain opaque, offering predictions without the transparent, stepwise reasoning clinicians rely on. We present a framework that brings…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Andriy Myronenko , Dong Yang , Baris Turkbey , Mariam Aboian , Sena Azamat , Esra Akcicek , Hongxu Yin , Pavlo Molchanov , Marc Edgar , Yufan He , Pengfei Guo , Yucheng Tang , Daguang Xu

Accurate tumor analysis is central to clinical radiology and precision oncology, where early detection, reliable lesion characterization, and pathology-level risk assessment guide diagnosis and treatment planning. Chain-of-Thought (CoT)…

Chest X-ray interpretation is one of the most frequently performed diagnostic tasks in medicine and a primary target for AI development, yet current vision-language models are primarily trained on datasets of paired images and reports, not…

Artificial intelligence (AI)-based chest X-ray (CXR) interpretation assistants have demonstrated significant progress and are increasingly being applied in clinical settings. However, contemporary medical AI models often adhere to a…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Jinquan Guan , Qi Chen , Lizhou Liang , Yuhang Liu , Vu Minh Hieu Phan , Minh-Son To , Jian Chen , Yutong Xie

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Juntao Jiang , Jiangning Zhang , Yali Bi , Jinsheng Bai , Weixuan Liu , Weiwei Jin , Zhucun Xue , Yong Liu , Xiaobin Hu , Shuicheng Yan

Deep learning models have revolutionized medical imaging and diagnostics, yet their opaque nature poses challenges for clinical adoption and trust. Amongst approaches to improve model interpretability, concept-based explanations aim to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-24 Vijay Sadashivaiah , Pingkun Yan , James A. Hendler

Chest X-ray (CXR) imaging is one of the most widely used diagnostic modalities in clinical practice, encompassing a broad spectrum of diagnostic tasks. Recent advancements have seen the extensive application of reasoning-based multimodal…

Chain-of-thought (CoT) reasoning has advanced medical visual question answering (VQA), yet most existing CoT rationales are free-form and fail to capture the structured reasoning process clinicians actually follow. This work asks: Can…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Lin Fan , Yafei Ou , Zhipeng Deng , Pengyu Dai , Hou Chongxian , Jiale Yan , Yaqian Li , Kaiwen Long , Xun Gong , Masayuki Ikebe , Yefeng Zheng

Recently large vision-language models have shown potential when interpreting complex images and generating natural language descriptions using advanced reasoning. Medicine's inherently multimodal nature incorporating scans and text-based…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Naman Sharma

Faithful reasoning in medical vision-language models (VLMs) requires not only accurate predictions but also transparent alignment between textual rationales and visual evidence. While Chain-of-Thought (CoT) prompting has shown promise in…

Chest imaging plays an essential role in diagnosing and predicting patients with COVID-19 with evidence of worsening respiratory status. Many deep learning-based approaches for pneumonia recognition have been developed to enable…

Image and Video Processing · Electrical Eng. & Systems 2024-01-17 Shengchao Chen , Sufen Ren , Guanjun Wang , Mengxing Huang , Chenyang Xue

In the field of chest X-ray (CXR) diagnosis, existing works often focus solely on determining where a radiologist looks, typically through tasks such as detection, segmentation, or classification. However, these approaches are often…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Trong Thang Pham , Jacob Brecheisen , Anh Nguyen , Hien Nguyen , Ngan Le

Test-time scaling offers a promising way to improve the reasoning performance of vision-language large models (VLLMs) without additional training. In this paper, we explore a simple but effective approach for applying test-time scaling to…

Computer Vision and Pattern Recognition · Computer Science 2026-05-04 Yue Yao , Zelin Wen , Yan Tong , Xinyu Tian , Xuqing Li , Xiao Ma , Dongliang Xu , Tom Gedeon

Recent advances in multimodal techniques have led to significant progress in Medical Visual Question Answering (Med-VQA). However, most existing models focus on global image features rather than localizing disease-specific regions crucial…

Computational Engineering, Finance, and Science · Computer Science 2025-06-30 Yuan Wang , Jiaxiang Liu , Shujian Gao , Bin Feng , Zhihang Tang , Xiaotang Gai , Jian Wu , Zuozhu Liu

Radiologists highly desire fully automated versatile AI for medical imaging interpretation. However, the lack of extensively annotated large-scale multi-disease datasets has hindered the achievement of this goal. In this paper, we explore…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Weiwei Cao , Jianpeng Zhang , Yingda Xia , Tony C. W. Mok , Zi Li , Xianghua Ye , Le Lu , Jian Zheng , Yuxing Tang , Ling Zhang

Vision-language models (VLMs) often produce chain-of-thought (CoT) explanations that sound plausible yet fail to reflect the underlying decision process, undermining trust in high-stakes clinical use. Existing evaluations rarely catch this…

Longitudinal chest X-ray (CXR) interpretation requires reasoning over disease evolution across multiple patient visits, yet most existing medical VQA benchmarks focus on single images or short-horizon image pairs. We introduce MI-CXR, a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Sunghwan Steve Cho , Yunseok Han , Jaeyoung Do

Automated diagnosis using deep neural networks in chest radiography can help radiologists detect life-threatening diseases. However, existing methods only provide predictions without accurate explanations, undermining the trustworthiness of…

Computer Vision and Pattern Recognition · Computer Science 2021-03-22 Eunji Kim , Siwon Kim , Minji Seo , Sungroh Yoon

Chest X-ray plays a central role in thoracic diagnosis, and its interpretation inherently requires multi-step, evidence-grounded reasoning. However, large vision-language models (LVLMs) often generate plausible responses that are not…

Artificial Intelligence · Computer Science 2026-03-25 Hyungyung Lee , Hangyul Yoon , Edward Choi

Deep learning models show significant potential for advancing AI-assisted medical diagnostics, particularly in detecting lung cancer through medical image modalities such as chest X-rays. However, the black-box nature of these models poses…

Machine Learning · Computer Science 2025-03-31 Amy Rafferty , Rishi Ramaesh , Ajitha Rajan
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