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Protein language models have shown remarkable success in learning biological information from protein sequences. However, most existing models are limited by either autoencoding or autoregressive pre-training objectives, which makes them…

Quantitative Methods · Quantitative Biology 2024-12-10 Bo Chen , Xingyi Cheng , Pan Li , Yangli-ao Geng , Jing Gong , Shen Li , Zhilei Bei , Xu Tan , Boyan Wang , Xin Zeng , Chiming Liu , Aohan Zeng , Yuxiao Dong , Jie Tang , Le Song

Progress on training and architecture strategies has enabled LLMs with millions of tokens in context length. However, empirical evidence suggests that such long-context LLMs can consume far more text than they can reliably use. On the other…

Language Reasoning Models (LRMs) achieve strong performance by scaling test-time computation but often suffer from ``overthinking'', producing excessively long reasoning traces that increase latency and memory usage. Existing LRMs typically…

Proteins encode diverse functions within complex three-dimensional structures, yet most deep learning representations remain highly entangled, obscuring the biophysical signals that underlie function. Here we introduce ProtDiS, a…

Biomolecules · Quantitative Biology 2026-05-26 Mingqing Wang , Zhiwei Nie , Athanasios V. Vasilakos , Yonghong He , Zhixiang Ren

Self-supervised training of language models (LMs) has seen great success for protein sequences in learning meaningful representations and for generative drug design. Most protein LMs are based on the Transformer architecture trained on…

Biomolecules · Quantitative Biology 2025-04-03 Yingheng Wang , Zichen Wang , Gil Sadeh , Luca Zancato , Alessandro Achille , George Karypis , Huzefa Rangwala

Effective training of today's large language models (LLMs) depends on large batches and long sequences for throughput and accuracy. To handle variable-length sequences on hardware accelerators, it is common practice to introduce padding…

Computation and Language · Computer Science 2022-10-07 Mario Michael Krell , Matej Kosec , Sergio P. Perez , Andrew Fitzgibbon

Large language models (LLMs) are commonly trained on datasets consisting of fixed-length token sequences. These datasets are created by randomly concatenating documents of various lengths and then chunking them into sequences of a…

Computation and Language · Computer Science 2025-01-08 Hadi Pouransari , Chun-Liang Li , Jen-Hao Rick Chang , Pavan Kumar Anasosalu Vasu , Cem Koc , Vaishaal Shankar , Oncel Tuzel

Large Language Models (LLMs) have demonstrated success across many benchmarks. However, they still exhibit limitations in long-context scenarios, primarily due to their short effective context length, quadratic computational complexity, and…

Computation and Language · Computer Science 2025-09-26 Manlai Liang , Mandi Liu , Jiangzhou Ji , Huaijun Li , Haobo Yang , Yaohan He , Jinlong Li

Previous work on augmenting large multimodal models (LMMs) for text-to-image (T2I) generation has focused on enriching the input space of in-context learning (ICL). This includes providing a few demonstrations and optimizing image…

Computation and Language · Computer Science 2025-01-14 Yongyu Mu , Hengyu Li , Junxin Wang , Xiaoxuan Zhou , Chenglong Wang , Yingfeng Luo , Qiaozhi He , Tong Xiao , Guocheng Chen , Jingbo Zhu

In-context learning (ICL) enables large language models (LLMs) to acquire new behaviors from the input sequence alone without any parameter updates. Recent studies have shown that ICL can surpass the original meaning learned in pretraining…

Machine Learning · Computer Science 2025-07-31 Yongyi Yang , Hidenori Tanaka , Wei Hu

Repository-level code intelligence tasks require large language models (LLMs) to process long, multi-file contexts. Such inputs introduce three challenges: crucial context can be obscured by noise, truncated due to limited windows, and…

Software Engineering · Computer Science 2026-04-16 Jia Feng , Zhanyue Qin , Cuiyun Gao , Ruiqi Wang , Chaozheng Wang , Yingwei Ma , Xiaoyuan Xie

In-context learning (ICL) has transformed the use of large language models (LLMs) for NLP tasks, enabling few-shot learning by conditioning on labeled examples without finetuning. Despite its effectiveness, ICL is prone to errors,…

Computation and Language · Computer Science 2025-03-21 Mario Sanz-Guerrero , Katharina von der Wense

Test-Time Training (TTT) models context dependencies by adapting part of the model's weights (referred to as fast weights) during inference. This fast weight, akin to recurrent states in RNNs, stores temporary memories of past tokens in the…

Machine Learning · Computer Science 2025-06-02 Tianyuan Zhang , Sai Bi , Yicong Hong , Kai Zhang , Fujun Luan , Songlin Yang , Kalyan Sunkavalli , William T. Freeman , Hao Tan

Transformer-based Large Language Models (LLMs) often impose limitations on the length of the text input to ensure the generation of fluent and relevant responses. This constraint restricts their applicability in scenarios involving long…

Computation and Language · Computer Science 2023-12-18 Weizhi Fei , Xueyan Niu , Pingyi Zhou , Lu Hou , Bo Bai , Lei Deng , Wei Han

Large Language Models (LLMs) have demonstrated great performance in few-shot In-Context Learning (ICL) for a variety of generative and discriminative chemical design tasks. The newly expanded context windows of LLMs can further improve ICL…

Multimodal Large Language Models (MLLMs) are becoming increasingly popular, while the high computational cost associated with multimodal data input, particularly from visual tokens, poses a significant challenge. Existing training-based…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Xudong Tan , Peng Ye , Chongjun Tu , Jianjian Cao , Yaoxin Yang , Lin Zhang , Dongzhan Zhou , Tao Chen

Molecule-text modeling, which aims to facilitate molecule-relevant tasks with a textual interface and textual knowledge, is an emerging research direction. Beyond single molecules, studying reaction-text modeling holds promise for helping…

Quantitative Methods · Quantitative Biology 2024-05-24 Zhiyuan Liu , Yaorui Shi , An Zhang , Sihang Li , Enzhi Zhang , Xiang Wang , Kenji Kawaguchi , Tat-Seng Chua

Evaluating the quality of machine-generated natural language content is a challenging task in Natural Language Processing (NLP). Recently, large language models (LLMs) like GPT-4 have been employed for this purpose, but they are…

Computation and Language · Computer Science 2024-12-23 Daniil Larionov , Steffen Eger

While Multimodal Large Language Models (MLLMs) demonstrate impressive capabilities, their substantial computational and memory requirements pose significant barriers to practical deployment. Current parameter reduction techniques primarily…

Computation and Language · Computer Science 2025-07-29 Yiran Huang , Lukas Thede , Massimiliano Mancini , Wenjia Xu , Zeynep Akata

In-context learning (ICL) enables efficient few-shot learning in large language models (LLMs) without training, but suffers from the quadratic input complexity of transformers, limiting the maximum number of exemplars. While various…

Computation and Language · Computer Science 2025-10-10 Shaoyi Zheng , Canyu Zhang , Tianyi Zhou , Shengjie Wang
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