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Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro…

Machine Learning · Computer Science 2026-03-18 Camille Jimenez Cortes , Philippe Lalanda , German Vega

We present an approach to domain adaptation, addressing the case where data from the source domain is abundant, labelled data from the target domain is limited or non-existent, and a small amount of paired source-target data is available.…

Machine Learning · Statistics 2020-03-20 Lawrence G. Phillips , David B. Grimes , Yihan Jessie Li

While high-resolution pathology images lend themselves well to `data hungry' deep learning algorithms, obtaining exhaustive annotations on these images is a major challenge. In this paper, we propose a self-supervised CNN approach to…

Computer Vision and Pattern Recognition · Computer Science 2020-08-14 Navid Alemi Koohbanani , Balagopal Unnikrishnan , Syed Ali Khurram , Pavitra Krishnaswamy , Nasir Rajpoot

In the absence of labeled target data, unsupervised domain adaptation approaches seek to align the marginal distributions of the source and target domains in order to train a classifier for the target. Unsupervised domain alignment…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Sachin Chhabra , Hemanth Venkateswara , Baoxin Li

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Large-scale labeled training datasets have enabled deep neural networks to excel on a wide range of benchmark vision tasks. However, in many applications it is prohibitively expensive or time-consuming to obtain large quantities of labeled…

Computer Vision and Pattern Recognition · Computer Science 2018-03-28 Sicheng Zhao , Bichen Wu , Joseph Gonzalez , Sanjit A. Seshia , Kurt Keutzer

"Self-training" has become a dominant method for semantic segmentation via unsupervised domain adaptation (UDA). It creates a set of pseudo labels for the target domain to give explicit supervision. However, the pseudo labels are noisy,…

Computer Vision and Pattern Recognition · Computer Science 2021-10-22 Inseop Chung , Jayeon Yoo , Nojun Kwak

Models capable of leveraging unlabelled data are crucial in overcoming large distribution gaps between the acquired datasets across different imaging devices and configurations. In this regard, self-training techniques based on…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Negin Ghamsarian , Javier Gamazo Tejero , Pablo Márquez Neila , Sebastian Wolf , Martin Zinkernagel , Klaus Schoeffmann , Raphael Sznitman

Domain shift is a significant challenge in machine learning, particularly in medical applications where data distributions differ across institutions due to variations in data collection practices, equipment, and procedures. This can…

Machine Learning · Computer Science 2025-06-30 Takumi Okuo , Shinnosuke Matsuo , Shota Harada , Kiyohito Tanaka , Ryoma Bise

Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

Increasing data set sizes of 3D microscopy imaging experiments demand for an automation of segmentation processes to be able to extract meaningful biomedical information. Due to the shortage of annotated 3D image data that can be used for…

Image and Video Processing · Electrical Eng. & Systems 2022-02-02 Dennis Eschweiler , Richard S. Smith , Johannes Stegmaier

Cell detection is an important task in biomedical research. Recently, deep learning methods have made it possible to improve the performance of cell detection. However, a detection network trained with training data under a specific…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Hyeonwoo Cho , Kazuya Nishimura , Kazuhide Watanabe , Ryoma Bise

Learning to estimate object pose often requires ground-truth (GT) labels, such as CAD model and absolute-scale object pose, which is expensive and laborious to obtain in the real world. To tackle this problem, we propose an unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2022-04-07 Taeyeop Lee , Byeong-Uk Lee , Inkyu Shin , Jaesung Choe , Ukcheol Shin , In So Kweon , Kuk-Jin Yoon

While supervised learning has achieved remarkable success, obtaining large-scale labeled datasets in biomedical imaging is often impractical due to high costs and the time-consuming annotations required from radiologists. Semi-supervised…

Image and Video Processing · Electrical Eng. & Systems 2024-01-19 Yuanbin Chen , Tao Wang , Hui Tang , Longxuan Zhao , Ruige Zong , Shun Chen , Tao Tan , Xinlin Zhang , Tong Tong

Domain adaptation for semantic image segmentation is very necessary since manually labeling large datasets with pixel-level labels is expensive and time consuming. Existing domain adaptation techniques either work on limited datasets, or…

Computer Vision and Pattern Recognition · Computer Science 2019-04-25 Yunsheng Li , Lu Yuan , Nuno Vasconcelos

Deep neural networks currently deliver promising results for microscopy image cell segmentation, but they require large-scale labelled databases, which is a costly and time-consuming process. In this work, we relax the labelling requirement…

Computer Vision and Pattern Recognition · Computer Science 2022-08-04 Youssef Dawoud , Katharina Ernst , Gustavo Carneiro , Vasileios Belagiannis

Semi-supervised learning has the potential to improve the data-efficiency of training data-hungry deep neural networks, which is especially important for medical image analysis tasks where labeled data is scarce. In this work, we present a…

Computer Vision and Pattern Recognition · Computer Science 2022-10-04 Boon Peng Yap , Beng Koon Ng

Supervised deep learning for semantic segmentation has achieved excellent results in accurately identifying anatomical and pathological structures in medical images. However, it often requires large annotated training datasets, which limits…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Luca Ciampi , Gabriele Lagani , Giuseppe Amato , Fabrizio Falchi

Domain adaptation (DA) has drawn high interests for its capacity to adapt a model trained on labeled source data to perform well on unlabeled or weakly labeled target data from a different domain. Most common DA techniques require the…

Computer Vision and Pattern Recognition · Computer Science 2021-04-09 Mathilde Bateson , Hoel Kervadec , Jose Dolz , Herve Lombaert , Ismail Ben Ayed

In the arena of language model fine-tuning, the traditional approaches, such as Domain-Adaptive Pretraining (DAPT) and Task-Adaptive Pretraining (TAPT), although effective, but computational intensive. This research introduces a novel…

Computation and Language · Computer Science 2024-05-10 Keyu Chen , Yuan Pang , Zi Yang