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Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Recent studies proposed the use of Total Correlation to describe functional connectivity among brain regions as a multivariate alternative to conventional pair-wise measures such as correlation or mutual information. In this work we build…

Neurons and Cognition · Quantitative Biology 2022-11-28 Qiang Li , Greg Ver Steeg , Shujian Yu , Jesus Malo

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven…

Neurons and Cognition · Quantitative Biology 2013-04-16 Gaël Varoquaux , R. C. Craddock

Dynamic functional connectivity, as measured by the time-varying covariance of neurological signals, is believed to play an important role in many aspects of cognition. While many methods have been proposed, reliably establishing the…

Methodology · Statistics 2019-10-30 Lingge Li , Dustin Pluta , Babak Shahbaba , Norbert Fortin , Hernando Ombao , Pierre Baldi

Background: Recent studies have indicated that functional connectivity is dynamic even during rest. A common approach to modeling the dynamic functional connectivity in whole-brain resting-state fMRI is to compute the correlation between…

Neurons and Cognition · Quantitative Biology 2019-11-05 Shih-Gu Huang , S. Balqis Samdin , Chee-Ming Ting , Hernando Ombao , Moo K. Chung

In recent years, graph neural networks (GNNs) have been widely applied in the analysis of brain fMRI, yet defining the connectivity between ROIs remains a challenge in noisy fMRI data. Among all approaches, Functional Connectome (FC) is the…

Machine Learning · Computer Science 2025-04-09 Jiyao Wang , Nicha C. Dvornek , Peiyu Duan , Lawrence H. Staib , Pamela Ventola , James S. Duncan

Now over 20 years old, functional MRI (fMRI) has a large and growing literature that is best synthesised with meta-analytic tools. As most authors do not share image data, only the peak activation coordinates (foci) reported in the paper…

Coordinate-based meta-analysis combines evidence from a collection of Neuroimaging studies to estimate brain activation. In such analyses, a key practical challenge is to find a computationally efficient approach with good statistical…

We propose a method that combines signals from many brain regions observed in functional Magnetic Resonance Imaging (fMRI) to predict the subject's behavior during a scanning session. Such predictions suffer from the huge number of brain…

Computer Vision and Pattern Recognition · Computer Science 2011-04-29 Vincent Michel , Alexandre Gramfort , Gaël Varoquaux , Evelyn Eger , Christine Keribin , Bertrand Thirion

This study proposes an approach to estimate the functional localization and connectivity from CBF and BOLD signals simultaneously measured by ASL (arterial spin labeling) MRI, especially using exploratory Structural Equation Modeling…

Neurons and Cognition · Quantitative Biology 2017-04-11 Jiancheng Zhuang

Functional data is a powerful tool for capturing and analyzing complex patterns and relationships in a variety of fields, allowing for more precise modeling, visualization, and decision-making. For example, in healthcare, functional data…

Methodology · Statistics 2023-04-26 Xiyuan Gao , Jiayi Wang , Guanyu Hu , Jianguo Sun

Physical activity (PA) intervention studies often collect repeated intensity measurements over long observation periods. Quantifying the variation in intervention effects over the study period is critical to evaluating and improving…

Applications · Statistics 2026-05-12 Nidhi Pai , Yu Lu , Kristin A. Linn , Erjia Cui

This paper proposes a novel approach of integrating different neuroimaging techniques to characterize an autistic brain. Different techniques like EEG, fMRI and DTI have traditionally been used to find biomarkers for autism, but there have…

Dynamic networks have been increasingly used to characterize brain connectivity that varies during resting and task states. In such characterizations, a connectivity network is typically measured at each time point for a subject over a…

Methodology · Statistics 2023-03-23 Maoyu Zhang , Biao Cai , Wenlin Dai , Dehan Kong , Hongyu Zhao , Jingfei Zhang

The estimation of causal network architectures in the brain is fundamental for understanding cognitive information processes. However, access to the dynamic processes underlying cognition is limited to indirect measurements of the hidden…

Neurons and Cognition · Quantitative Biology 2020-08-17 H. C. Ruiz-Euler , H. J. Kappen

Whole-brain computational modeling based on structural connectivity has shown great promise in successfully simulating fMRI BOLD signals with temporal co-activation patterns that are highly similar to empirical functional connectivity…

Neurons and Cognition · Quantitative Biology 2019-11-14 Neda Kaboodvand , Martijn P van den Heuvel , Peter Fransson

These days, computational diagnosis strategies of neuropsychiatric disorders are gaining attention day by day. It's critical to determine the brain's functional connectivity based on Functional-Magnetic-Resonance-Imaging(fMRI) to diagnose…

Computer Vision and Pattern Recognition · Computer Science 2022-05-05 Sartaj Ahmed Salman , Zhichao Lian , Marva Saleem , Yuduo Zhang

The primary motivation and application in this article come from brain imaging studies on cognitive impairment in elderly subjects with brain disorders. We propose a regularized Haar wavelet-based approach for the analysis of…

Applications · Statistics 2014-08-11 Xuejing Wang , Bin Nan , Ji Zhu , Robert Koeppe

In neuroimaging, a large number of correlated tests are routinely performed to detect active voxels in single-subject experiments or to detect regions that differ between individuals belonging to different groups. In order to bound the…

The human brain can be conceptualized as a dynamical system. Utilizing resting state fMRI time series imaging, we can study the underlying dynamics at ear-marked Regions of Interest (ROIs) to understand structure or lack thereof. This…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Ninad Aithal , Chakka Sai Pradeep , Neelam Sinha