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In order to respond to environmental signals, cells often use small molecular circuits to transmit information about their surroundings. Recently, motivated by concrete examples in signaling and gene regulation, a body of work has focused…

Molecular Networks · Quantitative Biology 2020-01-08 P. Szymańska-Rożek , D. Villamaina , J. Miȩkisz , A. M. Walczak

Living cells must control the reading out or "expression" of information encoded in their genomes, and this regulation often is mediated by transcription factors--proteins that bind to DNA and either enhance or repress the expression of…

Molecular Networks · Quantitative Biology 2013-08-01 Gašper Tkačik , Aleksandra M Walczak , William Bialek

Virtually all cells use energy and ion-specific membrane pumps to maintain large transmembrane gradients of Na$^+$, K$^+$, Cl$^-$, Mg$^{++}$, and Ca$^{++}$. Although they consume up to 1/3 of a cell's energy budget, the corresponding…

Cell Behavior · Quantitative Biology 2024-03-18 Dipesh Niraula , Issam El Naqa , Jack Adam Tuszynski , Robert A. Gatenby

Biological Petri Nets (Bio-PNs) require extensions beyond classical formalism to capture biochemical reality: multiple reactions simultaneously affect shared metabolites through convergent production or regulatory coupling, while signal…

Molecular Networks · Quantitative Biology 2026-01-05 Eugenio Simao

We study the phase transition of the Ising model in networks with core-periphery structures. By Monte Carlo simulations, we show that prior to the order-disorder phase transition the system organizes into an inhomogeneous intermediate phase…

Statistical Mechanics · Physics 2018-06-12 Hanshuang Chen , Haifeng Zhang , Chuansheng Shen

Quantum information processing exploits all the features quantum mechanics offers. Among them there is the possibility to induce nonlinear maps on a quantum system by involving two or more identical copies of the given system in the same…

Quantum Physics · Physics 2019-03-05 Martin Malachov , Igor Jex , Orsolya Kálmán , Tamás Kiss

The first-order transition of the charge-transfer complex TTF-CA (tetrathiafulvalene-chloranil) is both a neutral-ionic and a Peierls transition. In related organic charge transfer complexes, cooling at ambient pressure increases the…

Strongly Correlated Electrons · Physics 2007-05-23 A. Girlando , A. Painelli , S. A. Bewick , Z. G. Soos

The thermodynamic entropy of coarse-grained (CG) models stands as one of the most important properties for quantifying the missing information during the CG process and for establishing transferable (or extendible) CG interactions. However,…

Chemical Physics · Physics 2024-04-10 Jaehyeok Jin , David R. Reichman

In this paper, we study the problem of formation keeping of a network of strictly passive systems when very coarse information is exchanged. We assume that neighboring agents only know whether their relative position is larger or smaller…

Systems and Control · Computer Science 2013-08-01 Matin Jafarian , Claudio De Persis

Computation in the brain involves multiple types of neurons, yet the organizing principles for how these neurons work together remain unclear. Information theory has offered explanations for how different types of neurons can optimize the…

Neurons and Cognition · Quantitative Biology 2015-06-22 David B. Kastner , Stephen A. Baccus , Tatyana O. Sharpee

An influence of nonlinear interference processes at quantum transitions under strong resonance electromagnetic fields on absorption, amplification and refractive indices as well as on four-wave mixing processes is investigated. Doppler…

Quantum Physics · Physics 2015-06-26 A. K. Popov

We propose a new way of investigating phase transitions in the context of information theory. We use an information-entropic measure of spatial complexity known as configurational entropy (CE) to quantify both the storage and exchange of…

Statistical Mechanics · Physics 2018-03-23 Damian Sowinski , Marcelo Gleiser

Given the stochastic nature of gene expression, genetically identical cells exposed to the same environmental inputs will produce different outputs. This heterogeneity has been hypothesized to have consequences for how cells are able to…

Molecular Networks · Quantitative Biology 2020-08-19 Manuel Razo-Mejia , Sarah Marzen , Griffin Chure , Rachel Taubman , Muir Morrison , Rob Phillips

Physics perfectly describes neuronal operation, provided that we take into account that biology uses slow, positively charged ions rather than electrons as charge carriers and remove untested ad hoc hypotheses that contradict science's…

Biological Physics · Physics 2026-04-13 János Végh

A toggle switch consists of two genes that mutually repress each other. This regulatory motif is active during cell differentiation and is thought to act as a memory device, being able to choose and maintain cell fate decisions. In this…

Molecular Networks · Quantitative Biology 2018-12-26 Michael K. Strasser , Fabian J. Theis , Carsten Marr

The so-called Mixed Feedback Loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer. It has been found to be statistically over-represented in statistical…

Molecular Networks · Quantitative Biology 2009-11-11 Paul Francois , Vincent Hakim

Living cells display a remarkable capacity to compartmentalize their functional biochemistry. A particularly fascinating example is the cell nucleus. Exchange of macromolecules between the nucleus and the surrounding cytoplasm does not…

Subcellular Processes · Quantitative Biology 2017-04-19 Ching-Hao Wang , Pankaj Mehta , Michael Elbaum

The Unfolded Protein Response is the cell mechanism for maintaining the balance of properly folded proteins in the endoplasmic reticulum , the specialized cellular compartment. Although it is largely studied from a biological point of view,…

Molecular Networks · Quantitative Biology 2023-04-05 Nicole Luchetti , Alessandro Loppini , Margherita Anna Grazia Matarrese , Letizia Chiodo , Simonetta Filippi

Fluctuations in biochemical networks, e.g., in a living cell, have a complex origin that precludes a description of such systems in terms of bipartite or multipartite processes, as is usually done in the framework of stochastic and/or…

Statistical Mechanics · Physics 2020-01-29 R. Chétrite , M. L. Rosinberg , T. Sagawa , G. Tarjus

This paper investigates voltage stability in inverter-based power systems concerning fold and saddle-node bifurcations. An analytical expression is derived for the sensitivity of the stability margin using the normal vector to the…

Systems and Control · Electrical Eng. & Systems 2025-11-10 Sushobhan Chatterjee , Sijia Geng
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