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Accurate segmentation of topological tubular structures, such as blood vessels and roads, is crucial in various fields, ensuring accuracy and efficiency in downstream tasks. However, many factors complicate the task, including thin local…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Yaolei Qi , Yuting He , Xiaoming Qi , Yuan Zhang , Guanyu Yang

Spatial transcriptomics (ST) is an emerging technology that enables researchers to investigate the molecular relationships underlying tissue morphology. However, acquiring ST data remains prohibitively expensive, and traditional fixed-grid…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Chongyu Qu , Juming Xiong , Siqi Lu , Zhengyi Lu , Yanfan Zhu , Marilyn Lionts , Yuechen Yang , Yalin Zheng , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

Recent advances in cellular research demonstrate that scRNA-seq characterizes cellular heterogeneity, while spatial transcriptomics reveals the spatial distribution of gene expression. Cell representation is the fundamental issue in the two…

Genomics · Quantitative Biology 2025-01-16 Kai Zheng , Shaokai Wang , Yunpei Xu , Qiming Lei , Qichang Zhao , Xiao Liang , Qilong Feng , Yaohang Li , Min Li , Jinhui Xu , Jianxin Wang

Spatial transcriptomics is a modern sequencing technology that allows the measurement of the activity of thousands of genes in a tissue sample and map where the activity is occurring. This technology has enabled the study of the so-called…

Methodology · Statistics 2022-09-15 Andrea Sottosanti , Davide Risso

Accurate segmentation and classification of nuclei in histology images is critical but challenging due to nuclei heterogeneity, staining variations, and tissue complexity. Existing methods often struggle with limited dataset variability,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-22 Wenhua Zhang , Sen Yang , Meiwei Luo , Chuan He , Yuchen Li , Jun Zhang , Xiyue Wang , Fang Wang

Hierarchical clustering is a fundamental machine-learning technique for grouping data points into dendrograms. However, existing hierarchical clustering methods encounter two primary challenges: 1) Most methods specify dendrograms without a…

Machine Learning · Computer Science 2025-12-02 Guangjie Zeng , Hao Peng , Angsheng Li , Li Sun , Chunyang Liu , Shengze Li , Yicheng Pan , Philip S. Yu

Classification of topological phononics is challenging due to the lack of universal topological invariants and the randomness of structure patterns. Here, we show the unsupervised manifold learning for clustering topological phononics…

Disordered Systems and Neural Networks · Physics 2020-05-13 Yang Long , Jie Ren , Hong Chen

Synthesizing natural human motion that adapts to complex environments while allowing creative control remains a fundamental challenge in motion synthesis. Existing models often fall short, either by assuming flat terrain or lacking the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Xiaohan Zhang , Sebastian Starke , Vladimir Guzov , Zhensong Zhang , Eduardo Pérez Pellitero , Gerard Pons-Moll

Spatial transcriptomics enables gene expression profiling with spatial context, offering unprecedented insights into the tissue microenvironment. However, most computational models treat genes as isolated numerical features, ignoring the…

Machine Learning · Computer Science 2025-11-17 Jiangkai Long , Yanran Zhu , Chang Tang , Kun Sun , Yuanyuan Liu , Xuesong Yan

Motivated by the challenging segmentation task of pancreatic tubular networks, this paper tackles two commonly encountered problems in biomedical imaging: Topological consistency of the segmentation, and expensive or difficult annotation.…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Kasra Arnavaz , Oswin Krause , Kilian Zepf , Jelena M. Krivokapic , Silja Heilmann , Jakob Andreas Bærentzen , Pia Nyeng , Aasa Feragen

Semi-supervised semantic segmentation (SSSS) is vital in computational pathology, where dense annotations are costly and limited. Existing methods often rely on pixel-level consistency, which propagates noisy pseudo-labels and produces…

Image and Video Processing · Electrical Eng. & Systems 2025-11-14 Ha-Hieu Pham , Minh Le , Han Huynh , Nguyen Quoc Khanh Le , Huy-Hieu Pham

The effectiveness of Spatio-temporal Graph Neural Networks (STGNNs) in time-series applications is often limited by their dependence on fixed, hand-crafted input graph structures. Motivated by insights from the Topological Data Analysis…

Machine Learning · Computer Science 2025-03-20 Viet The Nguyen , Duy Anh Pham , An Thai Le , Jans Peter , Gunther Gust

Spectral clustering is a leading and popular technique in unsupervised data analysis. Two of its major limitations are scalability and generalization of the spectral embedding (i.e., out-of-sample-extension). In this paper we introduce a…

Machine Learning · Statistics 2024-11-06 Uri Shaham , Kelly Stanton , Henry Li , Boaz Nadler , Ronen Basri , Yuval Kluger

Sleep stage classification is crucial for detecting patients' health conditions. Existing models, which mainly use Convolutional Neural Networks (CNN) for modelling Euclidean data and Graph Convolution Networks (GNN) for modelling…

Machine Learning · Computer Science 2023-09-06 Yuze Liu , Ziming Zhao , Tiehua Zhang , Kang Wang , Xin Chen , Xiaowei Huang , Jun Yin , Zhishu Shen

Recent years have witnessed remarkable progress in multimodal learning within computational pathology. Existing models primarily rely on vision and language modalities; however, language alone lacks molecular specificity and offers limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Minghao Han , Dingkang Yang , Linhao Qu , Zizhi Chen , Gang Li , Han Wang , Jiacong Wang , Lihua Zhang

Semantic segmentation is one of the core tasks in the field of computer vision, and its goal is to accurately classify each pixel in an image. The traditional Unet model achieves efficient feature extraction and fusion through an…

Computer Vision and Pattern Recognition · Computer Science 2025-02-07 Xuan Li , Quanchao Lu , Yankaiqi Li , Muqing Li , Yijiashun Qi

This paper presents a novel clustering algorithm from the SPINEX (Similarity-based Predictions with Explainable Neighbors Exploration) algorithmic family. The newly proposed clustering variant leverages the concept of similarity and…

Machine Learning · Computer Science 2024-07-11 MZ Naser , Ahmed Naser

Spatial transcriptomics (ST) enables transcriptome-wide profiling while preserving the spatial context of tissues, offering unprecedented opportunities to study tissue organization and cell-cell interactions in situ. Despite recent…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Wei Wang , Quoc-Toan Ly , Chong Yu , Jun Bai

Spectral clustering is a fundamental method for graph partitioning, but its reliance on eigenvector computation limits scalability to massive graphs. Classical sparsification methods preserve spectral properties by sampling edges…

Machine Learning · Computer Science 2025-10-15 Kaiwen He , Petros Drineas , Rajiv Khanna

Encoding static images into spike trains is a fundamental step for enabling Spiking Neural Networks (SNNs) to process visual information. However, widely used methods such as rate coding, Poisson encoding, and time-to-first-spike (TTFS)…

Neural and Evolutionary Computing · Computer Science 2026-04-23 Minchi Hu