English
Related papers

Related papers: Driving Accurate Allergen Prediction with Protein …

200 papers

Studies show that developers' answers to the mobile app users' feedbacks on app stores can increase the apps' star rating. To help app developers generate answers that are related to the users' issues, recent studies develop models to…

Computation and Language · Computer Science 2022-02-07 Yue Cao , Fatemeh H. Fard

Deep learning-based approaches, particularly those leveraging pre-trained language models (PLMs), have shown promise in automated software vulnerability detection. However, existing methods are predominantly limited to specific programming…

Software Engineering · Computer Science 2025-05-13 Junji Yu , Honglin Shu , Michael Fu , Dong Wang , Chakkrit Tantithamthavorn , Yasutaka Kamei , Junjie Chen

The specific region of an antibody responsible for binding to an antigen, known as the paratope, is essential for immune recognition. Accurate identification of this small yet critical region can accelerate the development of therapeutic…

Biomolecules · Quantitative Biology 2025-10-08 Gabriel Athènes , Adam Woolfe , Thierry Mora , Aleksandra M. Walczak

Recent studies have shown the ability of large language models to perform a variety of tasks, including time series forecasting. The flexible nature of these models allows them to be used for many applications. In this paper, we present a…

Machine Learning · Computer Science 2024-11-04 Sarah Alnegheimish , Linh Nguyen , Laure Berti-Equille , Kalyan Veeramachaneni

Typical LLM responses tend to follow a default style, even though users often have distinct preferences regarding tone, verbosity, and formality that they do not explicitly state in their prompts. Evaluating whether personalization methods…

Computation and Language · Computer Science 2026-05-21 Philipp Spohn , Leander Girrbach , Zeynep Akata

Active Curriculum Language Modeling (ACLM; Hong et al., 2023) is a learner directed approach to training a language model. We proposed the original version of this process in our submission to the BabyLM 2023 task, and now we propose an…

Computation and Language · Computer Science 2024-12-05 Xudong Hong , Sharid Loáiciga , Asad Sayeed

Causal Language Modeling (CLM) and Masked Language Modeling (MLM) are two mainstream learning paradigms based on Transformer networks, specifically the Decoder-only and Encoder-only architectures. The strengths of each paradigm in…

Computation and Language · Computer Science 2024-12-05 Xinru Yu , Bin Guo , Shiwei Luo , Jie Wang , Tao Ji , Yuanbin Wu

We introduce LLMmap, a first-generation fingerprinting technique targeted at LLM-integrated applications. LLMmap employs an active fingerprinting approach, sending carefully crafted queries to the application and analyzing the responses to…

Cryptography and Security · Computer Science 2025-02-12 Dario Pasquini , Evgenios M. Kornaropoulos , Giuseppe Ateniese

The task of long-term action anticipation demands solutions that can effectively model temporal dynamics over extended periods while deeply understanding the inherent semantics of actions. Traditional approaches, which primarily rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Binglu Wang , Yao Tian , Shunzhou Wang , Le Yang

For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

Machine Learning · Computer Science 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Modern signal processing (SP) pipelines, whether model-based or data-driven, often constrained by complex and fragmented workflow, rely heavily on expert knowledge and manual engineering, and struggle with adaptability and generalization…

Machine Learning · Computer Science 2025-10-31 Junlong Ke , Qiying Hu , Shenghai Yuan , Yuecong Xu , Jianfei Yang

Large Language Models (LLMs) become the start-of-the-art solutions for a variety of natural language tasks and are integrated into real-world applications. However, LLMs can be potentially harmful in manifesting undesirable safety issues…

Artificial Intelligence · Computer Science 2024-03-05 Zhuoer Xu , Jianping Zhang , Shiwen Cui , Changhua Meng , Weiqiang Wang

Predicting protein stability changes induced by single-point mutations has been a persistent challenge over the years, attracting immense interest from numerous researchers. The ability to precisely predict protein thermostability is…

Biomolecules · Quantitative Biology 2023-12-08 Yijie Zhang , Zhangyang Gao , Cheng Tan , Stan Z. Li

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

Computation and Language · Computer Science 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Large Language Models (LLMs) have made extraordinary progress in the field of Artificial Intelligence and have demonstrated remarkable capabilities across a large variety of tasks and domains. However, as we venture closer to creating…

Artificial Intelligence · Computer Science 2023-10-04 Brandon Kynoch , Hugo Latapie , Dwane van der Sluis

While large language models (LLMs) are extensively used, there are raising concerns regarding privacy, security, and copyright due to their opaque training data, which brings the problem of detecting pre-training data on the table. Current…

Computation and Language · Computer Science 2024-08-01 Anqi Zhang , Chaofeng Wu

The 21st century is presenting humankind with unprecedented environmental and medical challenges. The ability to design novel proteins tailored for specific purposes could transform our ability to respond timely to these issues. Recent…

Biomolecules · Quantitative Biology 2022-08-24 Noelia Ferruz , Birte Höcker

The unprecedented advancements in Large Language Models (LLMs) have shown a profound impact on natural language processing but are yet to fully embrace the realm of 3D understanding. This paper introduces PointLLM, a preliminary effort to…

Computer Vision and Pattern Recognition · Computer Science 2024-09-10 Runsen Xu , Xiaolong Wang , Tai Wang , Yilun Chen , Jiangmiao Pang , Dahua Lin

The prediction of protein structures from sequences is an important task for function prediction, drug design, and related biological processes understanding. Recent advances have proved the power of language models (LMs) in processing the…

Quantitative Methods · Quantitative Biology 2022-12-01 Bozhen Hu , Jun Xia , Jiangbin Zheng , Cheng Tan , Yufei Huang , Yongjie Xu , Stan Z. Li

The ability to accurately model the fitness landscape of protein sequences is critical to a wide range of applications, from quantifying the effects of human variants on disease likelihood, to predicting immune-escape mutations in viruses…

Machine Learning · Computer Science 2022-05-30 Pascal Notin , Mafalda Dias , Jonathan Frazer , Javier Marchena-Hurtado , Aidan Gomez , Debora S. Marks , Yarin Gal