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Background: Diagnostic test accuracy (DTA) studies, like etiological studies, are susceptible to various biases including reference standard error bias, partial verification bias, spectrum effect, confounding, and bias from misassumption of…
Directed acyclic graphs provide a fundamental tool for representing directed dependence structures in multivariate network data, and are widely used to model financial and economic networks. However, accurate and interpretable estimation…
Assuming a directed acyclic graph (DAG) that represents prior knowledge of causal relationships between variables is a common starting point for cause-effect estimation. Existing literature typically invokes hypothetical domain expert…
During the COVID-19 pandemic, many institutions such as universities and workplaces implemented testing regimens with every member of some population tested longitudinally, and those testing positive isolated for some time. Although the…
The present study investigates the performance of several statistical tests to detect publication bias in diagnostic meta-analysis by means of simulation. While bivariate models should be used to pool data from primary studies in diagnostic…
We investigate variability overweighting, a previously undocumented bias in line graphs, where estimates of average value are biased toward areas of higher variability in that line. We found this effect across two preregistered experiments…
Using administrative patient-care data such as Electronic Health Records (EHR) and medical/ pharmaceutical claims for population-based scientific research has become increasingly common. With vast sample sizes leading to very small standard…
Datasets are rarely a realistic approximation of the target population. Say, prevalence is misrepresented, image quality is above clinical standards, etc. This mismatch is known as sampling bias. Sampling biases are a major hindrance for…
Directed acyclic graphs are widely used to describe the causal effects among random variables, and the inference of those causal effects has become an popular topic in statistics and machine learning, and has wide applications in…
Statistical samples, in order to be representative, have to be drawn from a population in a random and unbiased way. Nevertheless, it is common practice in the field of model-based diagnosis to make estimations from (biased) best-first…
When teaching and discussing statistical assumptions, our focus is oftentimes placed on how to test and address potential violations rather than the effects of violating assumptions on the estimates produced by our statistical models. The…
Algorithms for constraint-based causal discovery select graphical causal models among a space of possible candidates (e.g., all directed acyclic graphs) by executing a sequence of conditional independence tests. These may be used to inform…
Background: There is increasing interest in approaches for analyzing the effect of exposure mixtures on health. A key issue is how to simultaneously analyze often highly collinear components of the mixture, which can create problems such as…
Causal discovery from observational data is a challenging task that can only be solved up to a set of equivalent solutions, called an equivalence class. Such classes, which are often large in size, encode uncertainties about the orientation…
Meta-analyses of diagnostic test accuracy (DTA) studies have been gathering attention in research in clinical epidemiology and health technology development, and bivariate random-effects model is becoming a standard tool. However, standard…
We explore the usage of meta-learning to derive the causal direction between variables by optimizing over a measure of distribution simplicity. We incorporate a stochastic graph representation which includes latent variables and allows for…
An important step for any causal inference study design is understanding the distribution of the treated and control subjects in terms of measured baseline covariates. However, not all baseline variation is equally important. In the…
Ensemble models often achieve higher accuracy than single learners, but their ability to maintain small generalization gaps is not always well understood. This study examines how ensembles balance accuracy and overfitting across four…
In this article, we propose a new hypothesis testing method for directed acyclic graph (DAG). While there is a rich class of DAG estimation methods, there is a relative paucity of DAG inference solutions. Moreover, the existing methods…
In multivariate statistics, acyclic mixed graphs with directed and bidirected edges are widely used for compact representation of dependence structures that can arise in the presence of hidden (i.e., latent or unobserved) variables. Indeed,…