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The most pressing problems in science are neither empirical nor theoretical, but infrastructural. Scientific practice is defined by coproductive, mutually reinforcing infrastructural deficits and incentive systems that everywhere constrain…

General Literature · Computer Science 2022-09-16 Jonny L. Saunders

Artificial intelligence and machine learning are reshaping how we approach scientific discovery, not by replacing established methods but by extending what researchers can probe, predict, and design. In this roadmap we provide a…

Modern societies can be understood as the intersection of four interdependent systems: (1) the natural environment of geography, climate and weather; (2) the built environment of cities, engineered systems, and physical infrastructure; (3)…

Computers and Society · Computer Science 2017-05-08 Michael Dunaway , Robin Murphy , Nalini Venkatasubramanian , Leysia Palen , Daniel Lopresti

The rapid evolution of artificial intelligence has led to expectations of transformative impact on science, yet current systems remain fundamentally limited in enabling genuine scientific discovery. This perspective contends that progress…

Artificial Intelligence · Computer Science 2025-12-16 Karthik Duraisamy

Modern scientific discovery increasingly requires coordinating distributed facilities and heterogeneous resources, forcing researchers to act as manual workflow coordinators rather than scientists. Advances in AI leading to AI agents show…

Artificial Intelligence · Computer Science 2025-09-15 Woong Shin , Renan Souza , Daniel Rosendo , Frédéric Suter , Feiyi Wang , Prasanna Balaprakash , Rafael Ferreira da Silva

Scientific communities naturally tend to organize around data ecosystems created by the combination of their observational devices, their data repositories, and the workflows essential to carry their research from observation to discovery.…

Networking and Internet Architecture · Computer Science 2021-06-30 Mark Asch , François Bodin , Micah Beck , Terry Moore , Michela Taufer , Martin Swany , Jean-Pierre Vilotte

Embodied AI for Science (EAI4S) brings intelligence into the laboratory by uniting perception, reasoning, and robotic action to autonomously run experiments in the physical world. For the Global South, this shift is not about adopting…

Computers and Society · Computer Science 2026-04-09 Shaoshan Liu , Jie Tang , Marwa S. Hassan , Mohamed H. Sharkawy , Moustafa M. G. Fouda , Tiewei Shang , Zixin Wang

Research has become increasingly reliant on software, serving as the driving force behind bioinformatics, high performance computing, physics, machine learning and artificial intelligence, to name a few. While substantial progress has been…

Software Engineering · Computer Science 2024-05-30 Vanessa Sochat

Contemporary human-AI interaction research overlooks how AI systems fundamentally reshape human cognition pre-consciously, a critical blind spot for understanding distributed cognition. This paper introduces "Cognitive Infrastructure…

Human-Computer Interaction · Computer Science 2025-08-28 Giuseppe Riva

Artificial intelligence (AI) is being increasingly applied to scientific research, but its benefits remain unevenly distributed across different communities and disciplines. While technical challenges such as limited data, fragmented…

Machine Learning · Computer Science 2026-03-17 Georgia Channing , Avijit Ghosh

Artificial intelligence (AI) is reshaping how research is conceived, conducted, and communicated across fields from chemistry to biomedicine. This commentary examines how AI is transforming the research workflow. AI systems now help…

Artificial Intelligence · Computer Science 2025-11-14 Maksim E. Eren , Dorianis M. Perez

Progress in science is deeply bound to the effective use of high-performance computing infrastructures and to the efficient extraction of knowledge from vast amounts of data. Such data comes from different sources that follow a cycle…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-06-15 Rosa M Badia , Jorge Ejarque , Francesc Lordan , Daniele Lezzi , Javier Conejero , Javier Álvarez Cid-Fuentes , Yolanda Becerra , Anna Queralt

In the upcoming decade, deep learning may revolutionize the natural sciences, enhancing our capacity to model and predict natural occurrences. This could herald a new era of scientific exploration, bringing significant advancements across…

Artificial Intelligence · Computer Science 2023-10-13 Shuaiwen Leon Song , Bonnie Kruft , Minjia Zhang , Conglong Li , Shiyang Chen , Chengming Zhang , Masahiro Tanaka , Xiaoxia Wu , Jeff Rasley , Ammar Ahmad Awan , Connor Holmes , Martin Cai , Adam Ghanem , Zhongzhu Zhou , Yuxiong He , Pete Luferenko , Divya Kumar , Jonathan Weyn , Ruixiong Zhang , Sylwester Klocek , Volodymyr Vragov , Mohammed AlQuraishi , Gustaf Ahdritz , Christina Floristean , Cristina Negri , Rao Kotamarthi , Venkatram Vishwanath , Arvind Ramanathan , Sam Foreman , Kyle Hippe , Troy Arcomano , Romit Maulik , Maxim Zvyagin , Alexander Brace , Bin Zhang , Cindy Orozco Bohorquez , Austin Clyde , Bharat Kale , Danilo Perez-Rivera , Heng Ma , Carla M. Mann , Michael Irvin , J. Gregory Pauloski , Logan Ward , Valerie Hayot , Murali Emani , Zhen Xie , Diangen Lin , Maulik Shukla , Ian Foster , James J. Davis , Michael E. Papka , Thomas Brettin , Prasanna Balaprakash , Gina Tourassi , John Gounley , Heidi Hanson , Thomas E Potok , Massimiliano Lupo Pasini , Kate Evans , Dan Lu , Dalton Lunga , Junqi Yin , Sajal Dash , Feiyi Wang , Mallikarjun Shankar , Isaac Lyngaas , Xiao Wang , Guojing Cong , Pei Zhang , Ming Fan , Siyan Liu , Adolfy Hoisie , Shinjae Yoo , Yihui Ren , William Tang , Kyle Felker , Alexey Svyatkovskiy , Hang Liu , Ashwin Aji , Angela Dalton , Michael Schulte , Karl Schulz , Yuntian Deng , Weili Nie , Josh Romero , Christian Dallago , Arash Vahdat , Chaowei Xiao , Thomas Gibbs , Anima Anandkumar , Rick Stevens

The emergence of new technologies and innovative communication tools permits us to transcend societal challenges. While particle accelerators are essential instruments to improve our quality of life through science and technology, an…

Scientific workflows are powerful tools for management of scalable experiments, often composed of complex tasks running on distributed resources. Existing cyberinfrastructure provides components that can be utilized within repeatable…

Computers and Society · Computer Science 2019-03-05 Ilkay Altintas , Shweta Purawat , Daniel Crawl , Alok Singh , Kyle Marcus

Scientific discovery is being revolutionized by AI and autonomous systems, yet current autonomous laboratories remain isolated islands unable to collaborate across institutions. We present the Autonomous Interconnected Science Lab Ecosystem…

With the rapid development of Large Language Models (LLMs), AI agents have demonstrated increasing proficiency in scientific tasks, ranging from hypothesis generation and experimental design to manuscript writing. Such agent systems are…

Sharing, reusing, and synthesizing knowledge is central to the research process, both individually, and with others. These core functions are not supported by our formal scholarly publishing infrastructure: instead of the smooth functioning…

Human-Computer Interaction · Computer Science 2024-08-01 Joel Chan , Matthew Akamatsu , David Vargas , Lukas Kawerau , Michael Gartner

As AI systems become increasingly powerful, the need for safe AI has become more pressing. Humans are an attractive model for AI safety: as the only known agents capable of general intelligence, they perform robustly even under conditions…

Modern tools for biological research, especially microscopy, have rapidly advanced in recent years, which has led to the generation of increasingly large amounts of data on a regular basis. The result is that scientists desperately need…

Other Quantitative Biology · Quantitative Biology 2021-08-18 Andrey Andreev , Tom Morrell , Kristin Briney , Sandra Gesing , Uri Manor
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