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We present a keypoint-based foundation model for general purpose brain MRI registration, based on the recently-proposed KeyMorph framework. Our model, called BrainMorph, serves as a tool that supports multi-modal, pairwise, and scalable…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Alan Q. Wang , Rachit Saluja , Heejong Kim , Xinzi He , Adrian Dalca , Mert R. Sabuncu

In recent years, deep learning has shown great promise in the automated detection and classification of brain tumors from MRI images. However, achieving high accuracy and computational efficiency remains a challenge. In this research, we…

Image and Video Processing · Electrical Eng. & Systems 2025-07-10 Daniel Onah , Ravish Desai

Automated brain tumor segmentation methods have become well-established and reached performance levels offering clear clinical utility. These methods typically rely on four input magnetic resonance imaging (MRI) modalities: T1-weighted…

Advances in the motor imagery (MI)-based brain-computer interfaces (BCIs) allow control of several applications by decoding neurophysiological phenomena, which are usually recorded by electroencephalography (EEG) using a non-invasive…

Robust and generalizable segmentation of brain tumors on multi-parametric magnetic resonance imaging (MRI) remains difficult because tumor types differ widely. The BraTS 2025 Lighthouse Challenge benchmarks segmentation methods on diverse…

Multimodal groupwise registration aligns internal structures in a group of medical images. Current approaches to this problem involve developing similarity measures over the joint intensity profile of all images, which may be…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Xin Wang , Xinzhe Luo , Xiahai Zhuang

Magnetic Resonance Imaging (MRI) typically recruits multiple sequences (defined here as "modalities"). As each modality is designed to offer different anatomical and functional clinical information, there are evident disparities in the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-09 Chengjia Wang , Guang Yang , Giorgos Papanastasiou

Brain extraction and registration are important preprocessing steps in neuroimaging data analysis, where the goal is to extract the brain regions from MRI scans (i.e., extraction step) and align them with a target brain image (i.e.,…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Yao Su , Zhentian Qian , Lifang He , Xiangnan Kong

Robust and accurate alignment of multimodal medical images is a very challenging task, which however is very useful for many clinical applications. For example, magnetic resonance (MR) and transrectal ultrasound (TRUS) image registration is…

Computer Vision and Pattern Recognition · Computer Science 2018-10-03 Pingkun Yan , Sheng Xu , Ardeshir R. Rastinehad , Brad J. Wood

Medical image registration is critical for aligning anatomical structures across imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound. Among existing techniques, non-rigid registration (NRR)…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Sneha Sree C. , Dattesh Shanbhag , Sudhanya Chatterjee

Tumor segmentation from multi-modal brain MRI images is a challenging task due to the limited samples, high variance in shapes and uneven distribution of tumor morphology. The performance of automated medical image segmentation has been…

Image and Video Processing · Electrical Eng. & Systems 2024-02-13 Tianyi Ren , Ethan Honey , Harshitha Rebala , Abhishek Sharma , Agamdeep Chopra , Mehmet Kurt

Data augmentation is essential in medical imaging for improving classification accuracy, lesion detection, and organ segmentation under limited data conditions. However, two significant challenges remain. First, a pronounced domain gap…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Xuyin Qi , Zeyu Zhang , Canxuan Gang , Hao Zhang , Lei Zhang , Zhiwei Zhang , Yang Zhao

Multi-modal image registration plays a critical role in precision medicine but faces challenges from non-linear intensity relationships and local optima. While deep learning models enable rapid inference, they often suffer from…

Image and Video Processing · Electrical Eng. & Systems 2026-04-14 Boya Wang , Ruizhe Li , Chao Chen , Xin Chen

Purpose: The fusion of transrectal ultrasound (TRUS) and magnetic resonance (MR) images for guiding targeted prostate biopsy has significantly improved the biopsy yield of aggressive cancers. A key component of MR-TRUS fusion is image…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Grant Haskins , Jochen Kruecker , Uwe Kruger , Sheng Xu , Peter A. Pinto , Brad J. Wood , Pingkun Yan

Background: Differentiating radiation necrosis (RN) from tumor progression after stereotactic radiosurgery (SRS) remains a critical challenge in brain metastases. While histopathology represents the gold standard, its invasiveness limits…

This paper presents a novel predictive model, MetaMorph, for metamorphic registration of images with appearance changes (i.e., caused by brain tumors). In contrast to previous learning-based registration methods that have little or no…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Jian Wang , Jiarui Xing , Jason Druzgal , William M. Wells , Miaomiao Zhang

The diagnosis of brain cancer relies heavily on medical imaging techniques, with MRI being the most commonly used. It is necessary to perform automatic segmentation of brain tumors on MRI images. This project intends to build an MRI…

Image and Video Processing · Electrical Eng. & Systems 2024-06-28 Yuxiang Hu , Haowei Yang , Ting Xu , Shuyao He , Jiajie Yuan , Haozhang Deng

Brain tumor resection is a highly complex procedure with profound implications for survival and quality of life. Predicting patient outcomes is crucial to guide clinicians in balancing oncological control with preservation of neurological…

Accurate segmentation of brain resection cavities (RCs) aids in postoperative analysis and determining follow-up treatment. Convolutional neural networks (CNNs) are the state-of-the-art image segmentation technique, but require large…