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Bioinformatics tools are essential for complex computational biology tasks, yet their integration with emerging AI-agent frameworks is hindered by incompatible interfaces, heterogeneous input-output formats, and inconsistent parameter…

Quantitative Methods · Quantitative Biology 2025-10-03 Florensia Widjaja , Zhangtianyi Chen , Juexiao Zhou

Bioinformatics web servers are critical resources in modern biomedical research, facilitating interactive exploration of datasets through custom-built interfaces with rich visualization capabilities. However, this human-centric design…

Other Quantitative Biology · Quantitative Biology 2026-02-25 Matthias Flotho , Ian Ferenc Diks , Philipp Flotho , Leidy-Alejandra G. Molano , Pascal Hirsch , Andreas Keller

Large language model agents are increasingly used to automate web tasks such as product search, offer comparison, and checkout. Current research explores different interfaces through which these agents interact with websites, including…

Computation and Language · Computer Science 2026-04-22 Aaron Steiner , Ralph Peeters , Christian Bizer

Today's AI agents are built on large language models (LLMs) equipped with tools to access and modify external environments, such as corporate file systems, API-accessible platforms and websites. AI agents offer the promise of automating…

Computers and Society · Computer Science 2026-03-26 Merlin Stein

Agentic AI is transforming security by automating many tasks being performed manually. While initial agentic approaches employed a monolithic architecture, the Model-Context-Protocol has now enabled a remote-procedure call (RPC) paradigm to…

Cryptography and Security · Computer Science 2025-10-07 Zachary Ezetta , Wu-chang Feng

Since the introduction of the Model Context Protocol (MCP), the number of available tools for Large Language Models (LLMs) has increased significantly. These task-specific tool sets offer an alternative to general-purpose tools such as web…

Computation and Language · Computer Science 2025-12-12 Reza Esfandiarpoor , Vishwas Suryanarayanan , Stephen H. Bach , Vishal Chowdhary , Anthony Aue

Web browsers are a portal to the internet, where much of human activity is undertaken. Thus, there has been significant research work in AI agents that interact with the internet through web browsing. However, there is also another…

Computation and Language · Computer Science 2025-06-18 Yueqi Song , Frank Xu , Shuyan Zhou , Graham Neubig

Human-AI collaboration faces growing challenges as AI systems increasingly outperform humans on complex tasks, while humans remain responsible for orchestration, validation, and decision oversight. To address this imbalance, we introduce…

Human-Computer Interaction · Computer Science 2026-02-16 Yuanrong Tang , Huiling Peng , Bingxi Zhao , Hengyang Ding , Hanchao Song , Tianhong Wang , Chen Zhong , Jiangtao Gong

This paper introduces Agentic-AI Healthcare, a privacy-aware, multilingual, and explainable research prototype developed as a single-investigator project. The system leverages the emerging Model Context Protocol (MCP) to orchestrate…

Cryptography and Security · Computer Science 2025-10-06 Mohammed A. Shehab

The Model Context Protocol (MCP) is rapidly emerging as a pivotal open standard, designed to enhance agent-tool integration and interoperability, and is positioned to unlock a new era of powerful, interconnected, and genuinely utilitarian…

Computation and Language · Computer Science 2025-09-15 Zikang Guo , Benfeng Xu , Chiwei Zhu , Wentao Hong , Xiaorui Wang , Zhendong Mao

Computational data governance aims to make the enforcement of governance policies and legal obligations more efficient and reliable. Recent advances in natural language processing and agentic AI offer ways to improve how organizations share…

Emerging Technologies · Computer Science 2026-05-12 Marco Tonnarelli , Filippo Scaramuzza , Simon Harrer , Linus W. Dietz

The rapid progress of Artificial Intelligence Generated Content (AIGC) tools enables images, videos, and visualizations to be created on demand for webpage design, offering a flexible and increasingly adopted paradigm for modern UI/UX.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-17 Yan Li , Zezi Zeng , Yifan Yang , Yuqing Yang , Ning Liao , Weiwei Guo , Lili Qiu , Mingxi Cheng , Qi Dai , Zhendong Wang , Zhengyuan Yang , Xue Yang , Ji Li , Lijuan Wang , Chong Luo

The increased adoption of the Model Context Protocol (MCP) for AI Agents necessitates robust security for Enterprise integrations. This paper introduces the MCP Gateway to simplify self-hosted MCP server integration. The proposed…

Cryptography and Security · Computer Science 2025-04-29 Ivo Brett

Tool calling has emerged as a critical capability for AI agents. In contrast to conventional tool calling frameworks that rely on static, provider-specific tool definitions, the Model Context Protocol (MCP) offers a unified interface to…

Recent advancements in Large Language Models (LLMs) and multimodal counterparts have spurred significant interest in developing web agents -- AI systems capable of autonomously navigating and completing tasks within web environments. While…

Machine Learning · Computer Science 2025-06-13 Xing Han Lù , Gaurav Kamath , Marius Mosbach , Siva Reddy

The Model Context Protocol (MCP) standardizes how AI agents discover and invoke external tools, with over 10,000 active servers and 97 million monthly SDK downloads as of early 2026. Yet MCP does not yet standardize how agents safely…

Software Engineering · Computer Science 2026-04-16 Vasundra Srinivasan

The Model Context Protocol (MCP) is emerging as a standard interface through which large language model (LLM) agents discover and invoke external tools. However, existing MCP evaluations fall short along three key axes: realistic multi-step…

In the artificial intelligence space, as we transition from isolated large language models to autonomous agents capable of complex reasoning and tool use. While foundational architectures and local context management protocols have been…

Multiagent Systems · Computer Science 2026-02-18 Naveen Kumar Krishnan

The rise of AI agents introduces a fundamental shift in Visual Analytics (VA), in which agents act as a new user group. Current agentic approaches - based on computer vision and raw DOM access - fail to perform VA tasks accurately and…

Human-Computer Interaction · Computer Science 2026-04-01 Tobias Stähle , Péter Ferenc Gyarmati , Thilo Spinner , Rita Sevastjanova , Dominik Moritz , Mennatallah El-Assady

With advances in decision-making and reasoning capabilities, multimodal agents show strong potential in computer application scenarios. Past evaluations have mainly assessed GUI interaction skills, while tool invocation abilities, such as…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Hongrui Jia , Jitong Liao , Xi Zhang , Haiyang Xu , Tianbao Xie , Chaoya Jiang , Ming Yan , Si Liu , Wei Ye , Fei Huang
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