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Deploying deep neural networks for risk-sensitive tasks necessitates an uncertainty estimation mechanism. This paper introduces hierarchical selective classification, extending selective classification to a hierarchical setting. Our…

Machine Learning · Computer Science 2025-01-07 Shani Goren , Ido Galil , Ran El-Yaniv

Over the past few years, the use of machine learning models has emerged as a generic and powerful means for prediction purposes. At the same time, there is a growing demand for interpretability of prediction models. To determine which…

Machine Learning · Computer Science 2023-01-13 Joris Pries , Guus Berkelmans , Sandjai Bhulai , Rob van der Mei

Depression is a common mental disorder. Automatic depression detection tools using speech, enabled by machine learning, help early screening of depression. This paper addresses two limitations that may hinder the clinical implementations of…

Computation and Language · Computer Science 2023-10-09 Qingkun Deng , Saturnino Luz , Sofia de la Fuente Garcia

Multiple Instance Learning (MIL) is increasingly being used as a support tool within clinical settings for pathological diagnosis decisions, achieving high performance and removing the annotation burden. However, existing approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Sungrae Hong , Kyungeun Kim , Juhyeon Kim , Sol Lee , Jisu Shin , Chanjae Song , Mun Yong Yi

Monitoring complex systems results in massive multivariate time series data, and anomaly detection of these data is very important to maintain the normal operation of the systems. Despite the recent emergence of a large number of anomaly…

Machine Learning · Computer Science 2021-06-14 Liwei Deng , Xuanhao Chen , Yan Zhao , Kai Zheng

Variable selection in high-dimensional scenarios is of great interested in statistics. One application involves identifying differentially expressed genes in genomic analysis. Existing methods for addressing this problem have some limits or…

Methodology · Statistics 2018-06-19 Liuhua Peng , Long Qu , Dan Nettleton

One of the key elements of explanatory analysis of a predictive model is to assess the importance of individual variables. Rapid development of the area of predictive model exploration (also called explainable artificial intelligence or…

Machine Learning · Computer Science 2021-04-09 Katarzyna Pekala , Katarzyna Woznica , Przemyslaw Biecek

Scientists often want to learn about cause and effect from hierarchical data, collected from subunits nested inside units. Consider students in schools, cells in patients, or cities in states. In such settings, unit-level variables (e.g.…

Methodology · Statistics 2024-06-27 Eli N. Weinstein , David M. Blei

The proliferation of high-dimensional datasets in fields such as genomics, healthcare, and finance has created an urgent need for machine learning models that are both highly accurate and inherently interpretable. While traditional deep…

Machine Learning · Computer Science 2025-10-28 Rekha R Nair , Tina Babu , Alavikunhu Panthakkan , Hussain Al-Ahmad , Balamurugan Balusamy

Recent advancements in medicine have confirmed that brain disorders often comprise multiple subtypes of mechanisms, developmental trajectories, or severity levels. Such heterogeneity is often associated with demographic aspects (e.g., sex)…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Magdalini Paschali , Yu Hang Jiang , Spencer Siegel , Camila Gonzalez , Kilian M. Pohl , Akshay Chaudhari , Qingyu Zhao

Machine learning predictions are increasingly used to supplement incomplete or costly-to-measure outcomes in fields such as biomedical research, environmental science, and social science. However, treating predictions as ground truth…

Machine Learning · Statistics 2026-01-29 Yilin Song , Dan M. Kluger , Harsh Parikh , Tian Gu

The use of wearables in medicine and wellness, enabled by AI-based models, offers tremendous potential for real-time monitoring and interpretable event detection. Explainable AI (XAI) is required to assess what models have learned and build…

Signal Processing · Electrical Eng. & Systems 2026-03-16 Maurice Kuschel , Solveig Vieluf , Claus Reinsberger , Tobias Loddenkemper , Tanuj Hasija

Variable importance measures (VIMs) aim to quantify the contribution of each input covariate to the predictability of a given output. With the growing interest in explainable AI, numerous VIMs have been proposed, many of which are heuristic…

Methodology · Statistics 2025-09-23 Angel Reyero-Lobo , Pierre Neuvial , Bertrand Thirion

Numerous methods for probabilistic reasoning in large, complex belief or decision networks are currently being developed. There has been little research on automating the dynamic, incremental construction of decision models. A uniform…

Artificial Intelligence · Computer Science 2013-03-08 Soe-Tsyr Yuan

Risk scores are widely used for clinical decision making and commonly generated from logistic regression models. Machine-learning-based methods may work well for identifying important predictors, but such 'black box' variable selection…

Machine Learning · Computer Science 2024-12-31 Yilin Ning , Siqi Li , Marcus Eng Hock Ong , Feng Xie , Bibhas Chakraborty , Daniel Shu Wei Ting , Nan Liu

Clinical neuroimaging has recently witnessed explosive growth in data availability which brings studying heterogeneity in clinical cohorts to the spotlight. Normative modeling is an emerging statistical tool for achieving this objective.…

Statistical models are central to machine learning with broad applicability across a range of downstream tasks. The models are controlled by free parameters that are typically estimated from data by maximum-likelihood estimation or…

Machine Learning · Computer Science 2023-08-16 Vaidotas Simkus , Benjamin Rhodes , Michael U. Gutmann

We characterize and study variable importance (VIMP) and pairwise variable associations in binary regression trees. A key component involves the node mean squared error for a quantity we refer to as a maximal subtree. The theory naturally…

Machine Learning · Statistics 2009-09-29 Hemant Ishwaran

Risk of suicide attempt varies over time. Understanding the importance of risk factors measured at a mental health visit can help clinicians evaluate future risk and provide appropriate care during the visit. In prediction settings where…

Hierarchical time-series forecasting is essential for demand prediction across various industries. While machine learning models have obtained significant accuracy and scalability on such forecasting tasks, the interpretability of their…

Machine Learning · Computer Science 2026-03-09 Harshavardhan Kamarthi , Shangqing Xu , Xinjie Tong , Xingyu Zhou , James Peters , Joseph Czyzyk , B. Aditya Prakash