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The adoption of large language models (LLMs) in healthcare has attracted significant research interest. However, their performance in healthcare remains under-investigated and potentially limited, due to i) they lack rich domain-specific…

Artificial Intelligence · Computer Science 2024-05-21 Zishan Gu , Fenglin Liu , Changchang Yin , Ping Zhang

AI Agents can perform complex operations at great speed, but just like all the humans we have ever hired, their intelligence remains fallible. Miscommunications aren't noticed, systemic biases have no counter-action, and inner monologues…

Multiagent Systems · Computer Science 2026-01-22 Gopal Vijayaraghavan , Prasanth Jayachandran , Arun Murthy , Sunil Govindan , Vivek Subramanian

Identifying associations between imaging phenotypes, disease risk factors, and clinical outcomes is essential for understanding disease mechanisms. However, traditional approaches rely on human-driven hypothesis testing and selection of…

Artificial Intelligence · Computer Science 2025-09-09 Weitong Zhang , Mengyun Qiao , Chengqi Zang , Steven Niederer , Paul M Matthews , Wenjia Bai , Bernhard Kainz

Formulating a treatment plan is inherently a complex reasoning and refinement task rather than a simple generation problem. However, existing large language models (LLMs) mainly rely on one-shot output without explicit verification, which…

Artificial Intelligence · Computer Science 2026-05-08 Junkai Li , Yunghwei Lai , Tianyi Zhu , Zheng Long Lee , Weizhi Ma , Yang Liu

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context…

Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents. Tasks such as drug…

Artificial Intelligence · Computer Science 2025-12-15 Tim Cofala , Christian Kalfar , Jingge Xiao , Johanna Schrader , Michelle Tang , Wolfgang Nejdl

The justice system has increasingly employed AI techniques to enhance efficiency, yet limitations remain in improving the quality of decision-making, particularly regarding transparency and explainability needed to uphold public trust in…

Artificial Intelligence · Computer Science 2024-12-30 Cong Jiang , Xiaolei Yang

We propose GAM-Agent, a game-theoretic multi-agent framework for enhancing vision-language reasoning. Unlike prior single-agent or monolithic models, GAM-Agent formulates the reasoning process as a non-zero-sum game between base…

Artificial Intelligence · Computer Science 2025-05-30 Jusheng Zhang , Yijia Fan , Wenjun Lin , Ruiqi Chen , Haoyi Jiang , Wenhao Chai , Jian Wang , Keze Wang

While reasoning-enhanced large language models perform strongly on English medical tasks, a persistent multilingual gap remains, with substantially weaker reasoning in local languages, limiting equitable global medical deployment. To bridge…

The efficacy of AI agents in healthcare research is hindered by their reliance on static, predefined strategies. This creates a critical limitation: agents can become better tool-users but cannot learn to become better strategic planners, a…

Artificial Intelligence · Computer Science 2025-08-08 Huiya Zhao , Yinghao Zhu , Zixiang Wang , Yasha Wang , Junyi Gao , Liantao Ma

The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule…

Biomolecules · Quantitative Biology 2025-04-01 Bowen Gao , Yanwen Huang , Yiqiao Liu , Wenxuan Xie , Wei-Ying Ma , Ya-Qin Zhang , Yanyan Lan

Multi-agent systems have extended the capability of agentic AI. Instead of single inference passes, multiple agents perform collective reasoning to derive high quality answers. However, existing multi-agent orchestration relies on static…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-24 Chaoyi Ruan , Yiliang Wang , Ziji Shi , Jialin Li

Visual Language Models (VLMs) achieve promising results in medical reasoning but struggle with hallucinations, vague descriptions, inconsistent logic and poor localization. To address this, we propose a agent framework named Medical Visual…

Artificial Intelligence · Computer Science 2025-10-22 Guangfu Guo , Xiaoqian Lu , Yue Feng

Recent advances in medical large language models (LLMs), multimodal models, and agents demand evaluation frameworks that reflect real clinical workflows and safety constraints. We present MedBench v4, a nationwide, cloud-based benchmarking…

The rapid advancement of Large Language Models (LLMs) has stimulated interest in multi-agent collaboration for addressing complex medical tasks. However, the practical advantages of multi-agent collaboration approaches remain insufficiently…

Artificial Intelligence · Computer Science 2025-10-31 Yinghao Zhu , Ziyi He , Haoran Hu , Xiaochen Zheng , Xichen Zhang , Zixiang Wang , Junyi Gao , Liantao Ma , Lequan Yu

Medical reasoning models remain constrained by parametric knowledge and are thus susceptible to forgetting and hallucinations. DeepResearch (DR) models ground outputs in verifiable evidence from tools and perform strongly in general…

Artificial Intelligence · Computer Science 2026-02-05 Zihan Wang , Hao Wang , Shi Feng , Xiaocui Yang , Daling Wang , Yiqun Zhang , Jinghao Lin , Haihua Yang , Xiaozhong Ji

When are multi-agent LLM systems merely a collection of individual agents versus an integrated collective with higher-order structure? We introduce an information-theoretic framework to test -- in a purely data-driven way -- whether…

Multiagent Systems · Computer Science 2026-04-30 Christoph Riedl

Human social interactions depend on the ability to infer others' unspoken intentions, emotions, and beliefs-a cognitive skill grounded in the psychological concept of Theory of Mind (ToM). While large language models (LLMs) excel in…

Computation and Language · Computer Science 2025-10-15 Xuanming Zhang , Yuxuan Chen , Samuel Yeh , Sharon Li

PET theranostics is transforming precision oncology, yet treatment response varies substantially; many patients receiving 177Lu-PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) fail to respond,…

We present an architecture for ad hoc teamwork, which refers to collaboration in a team of agents without prior coordination. State of the art methods for this problem often include a data-driven component that uses a long history of prior…

Artificial Intelligence · Computer Science 2022-10-20 Hasra Dodampegama , Mohan Sridharan