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Autonomous coding agents built on large language models (LLMs) can now solve many general software and machine learning tasks, but they remain ineffective on complex, domain-specific scientific problems. Medical imaging is a particularly…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Roshan Kenia , Xiaoman Zhang , Pranav Rajpurkar

With advances in large language models (LLMs), researchers are creating new systems that can perform AI-driven analytics over large unstructured datasets. Recent work has explored executing such analytics queries using semantic operators --…

Artificial Intelligence · Computer Science 2025-09-04 Matthew Russo , Tim Kraska

Fully automated self-driving laboratories are promising to enable high-throughput and large-scale scientific discovery by reducing repetitive labour. However, effective automation requires deep integration of laboratory knowledge, which is…

Artificial Intelligence · Computer Science 2025-09-30 Shuxiang Cao , Zijian Zhang , Mohammed Alghadeer , Simone D Fasciati , Michele Piscitelli , Mustafa Bakr , Peter Leek , Alán Aspuru-Guzik

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited…

Robotics · Computer Science 2025-07-03 Yibo Qiu , Zan Huang , Zhiyu Wang , Handi Liu , Yiling Qiao , Yifeng Hu , Shu'ang Sun , Hangke Peng , Ronald X Xu , Mingzhai Sun

Autonomous agents powered by large language models (LLMs) promise to accelerate scientific discovery end-to-end, but rigorously evaluating their capacity for verifiable discovery remains a central challenge. Existing benchmarks face a…

Artificial Intelligence · Computer Science 2026-02-04 Zhen Wang , Fan Bai , Zhongyan Luo , Jinyan Su , Kaiser Sun , Xinle Yu , Jieyuan Liu , Kun Zhou , Claire Cardie , Mark Dredze , Eric P. Xing , Zhiting Hu

As Large Language Models (LLMs) increasingly operate as Deep Research (DR) Agents capable of autonomous investigation and information synthesis, reliable evaluation of their task performance has become a critical bottleneck. Current…

Computation and Language · Computer Science 2026-01-16 Yiwen Gao , Ruochen Zhao , Yang Deng , Wenxuan Zhang

Recent advances in large language models (LLMs) have enabled agentic systems that translate natural language intent into executable scientific visualization (SciVis) tasks. Despite rapid progress, the community lacks a principled and…

Tool-augmented large language models (LLMs) must tightly couple multi-step reasoning with external actions, yet existing benchmarks often confound this interplay with complex environment dynamics, memorized knowledge or dataset…

Artificial Intelligence · Computer Science 2026-03-20 Wanjia Zhao , Ludwig Schmidt , James Zou , Vidhisha Balachandran , Lingjiao Chen

Large language models (LLMs) have revolutionized the field of artificial intelligence, endowing it with sophisticated language understanding and generation capabilities. However, when faced with more complex and interconnected tasks that…

Artificial Intelligence · Computer Science 2023-10-06 Thorsten Händler

Advancements in large language models (LLMs) allow them to address diverse questions using human-like interfaces. Still, limitations in their training prevent them from answering accurately in scenarios that could benefit from multiple…

Artificial Intelligence · Computer Science 2025-04-09 Yoshitaka Inoue , Tianci Song , Xinling Wang , Augustin Luna , Tianfan Fu

Advanced Large Multimodal Models (LMMs) have demonstrated impressive performance in K-12 reasoning tasks, exhibiting great promise as intelligent tutors. Realizing this potential requires models to navigate real-world examinations…

Artificial Intelligence · Computer Science 2026-05-27 Xiaohan Wang , Mingze Yin , Yilin Zhao , Gang Liu , Dian Li

Pursuing artificial intelligence for biomedical science, a.k.a. AI Scientist, draws increasing attention, where one common approach is to build a copilot agent driven by Large Language Models (LLMs). However, to evaluate such systems,…

Computation and Language · Computer Science 2024-07-02 Xinna Lin , Siqi Ma , Junjie Shan , Xiaojing Zhang , Shell Xu Hu , Tiannan Guo , Stan Z. Li , Kaicheng Yu

Recent advancements in machine learning have significantly improved the identification of disease-associated genes from gene expression datasets. However, these processes often require extensive expertise and manual effort, limiting their…

Machine Learning · Computer Science 2025-04-09 Haoyang Liu , Shuyu Chen , Ye Zhang , Haohan Wang

High-dimensional data remains a pervasive challenge in machine learning, often undermining model interpretability and computational efficiency. While Large Language Models (LLMs) have shown promise for dimensionality reduction through…

Machine Learning · Computer Science 2025-10-08 Mohamed Bal-Ghaoui , Fayssal Sabri

Motivation: Developing high-performing bioinformatics models typically requires repeated cycles of hypothesis formulation, architectural redesign, and empirical validation, making progress slow, labor-intensive, and difficult to reproduce.…

Multiagent Systems · Computer Science 2026-01-22 Sunghyun Kim , Seokwoo Yun , Youngseo Yun , Youngrak Lee , Sangsoo Lim

Large language models (LLMs) excel in natural language generation but often confidently produce incorrect responses, especially in tasks like mathematical reasoning. Chain-of-thought prompting, self-verification, and multi-agent debate are…

Computation and Language · Computer Science 2026-03-30 Mahmood Hegazy

Quickly resolving issues reported in industrial applications is crucial to minimize economic impact. However, the required data analysis makes diagnosing the underlying root causes a challenging and time-consuming task, even for experts. In…

Computation and Language · Computer Science 2024-10-15 Jordis Emilia Herrmann , Aswath Mandakath Gopinath , Mikael Norrlof , Mark Niklas Müller

Objective: Large language models (LLMs) are increasingly applied in biomedical settings, and existing benchmark datasets have played an important role in supporting model development and evaluation. However, these benchmarks often have…

Computation and Language · Computer Science 2026-01-21 Kriti Bhattarai , Vipina K. Keloth , Donald Wright , Andrew Loza , Yang Ren , Hua Xu

Large language model (LLM) agents are increasingly capable of automating components of machine learning development, yet existing biomedical benchmarks mainly focus on question answering, reasoning, and tool usage, or evaluate only narrow…

Computational Engineering, Finance, and Science · Computer Science 2026-05-18 Loka Li , Duzhen Zhang , Xingbo Du , Leonard Song , Zixiao Wang , Assanali Aukenov , Noel Thomas , Shakhnazar Sailaukan , Yonghan Yang , Feilong Chen , Jiahua Dong , Kun Zhang , Bin Zhang , Le Song

Large Language Models (LLMs) have demonstrated strong capabilities in natural language reasoning, yet their application to Cyber Threat Intelligence (CTI) remains limited. CTI analysis involves distilling large volumes of unstructured…

Cryptography and Security · Computer Science 2026-02-17 Md Tanvirul Alam , Dipkamal Bhusal , Salman Ahmad , Nidhi Rastogi , Peter Worth