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Aligning millions of short DNA or RNA reads, of 75 to 250 base pairs each, to a reference genome is a significant computation problem in bioinformatics. We present a flexible and fast FPGA-based short read alignment tool. Our aligner makes…

Genomics · Quantitative Biology 2018-05-02 Nathaniel McVicar , Akina Hoshino , Anna La Torre , Thomas A. Reh , Walter L. Ruzzo , Scott Hauck

Domain adaptation investigates the problem of leveraging knowledge from a well-labeled source domain to an unlabeled target domain, where the two domains are drawn from different data distributions. Because of the distribution shifts,…

Computer Vision and Pattern Recognition · Computer Science 2019-07-12 Jingjing Li , Mengmeng Jing , Yue Xie , Ke Lu , Zi Huang

Residual neural networks (ResNets) are a promising class of deep neural networks that have shown excellent performance for a number of learning tasks, e.g., image classification and recognition. Mathematically, ResNet architectures can be…

Optimization and Control · Mathematics 2019-07-26 S. Günther , L. Ruthotto , J. B. Schroder , E. C. Cyr , N. R. Gauger

Today World Wide Web (WWW) has become a huge ocean of information and it is growing in size everyday. Downloading even a fraction of this mammoth data is like sailing through a huge ocean and it is a challenging task indeed. In order to…

Information Retrieval · Computer Science 2011-02-04 Debajyoti Mukhopadhyay , Sajal Mukherjee , Soumya Ghosh , Saheli Kar , Young-Chon Kim

For the 6G mobile networks, in-situ model downloading has emerged as an important use case to enable real-time adaptive artificial intelligence on edge devices. However, the simultaneous downloading of diverse and high-dimensional models to…

Information Theory · Computer Science 2023-07-31 Hai Wu , Qunsong Zeng , Kaibin Huang

We present a massively parallel Lagrange decomposition method for solving 0--1 integer linear programs occurring in structured prediction. We propose a new iterative update scheme for solving the Lagrangean dual and a perturbation technique…

Optimization and Control · Mathematics 2022-04-20 Ahmed Abbas , Paul Swoboda

Deep research agents, which synthesize information across diverse sources, are significantly constrained by the sequential nature of reasoning. This bottleneck results in high latency, poor runtime adaptability, and inefficient resource…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-31 Lunyiu Nie , Nedim Lipka , Ryan A. Rossi , Swarat Chaudhuri

Next Generation Sequencing (NGS) technology has resulted in massive amounts of proteomics and genomics data. This data is of no use if it is not properly analyzed. ETL (Extraction, Transformation, Loading) is an important step in designing…

Databases · Computer Science 2017-07-25 Shahzad Ahmed , M. Usman Ali , Javed Ferzund , Muhammad Atif Sarwar , Abbas Rehman , Atif Mehmood

Understanding how nonlinear dynamical systems (e.g., artificial neural networks and neural circuits) process information requires comparing their underlying dynamics at scale, across diverse architectures and large neural recordings. While…

Artificial Intelligence · Computer Science 2026-04-03 Arman Behrad , Mitchell Ostrow , Mohammad Taha Fakharian , Ila Fiete , Christian Beste , Shervin Safavi

RNA design aims to identify RNA sequences that fold into a target secondary structure. This task is challenging in terms of computational efficiency. Most existing methods focus on either minimum free energy (MFE)-based or ensemble-based…

Biomolecules · Quantitative Biology 2026-03-04 Tianshuo Zhou , David H. Mathews , Liang Huang

Ultra-dense networks (UDNs) represent a transformative access architecture for upcoming sixth generation (6G) systems, poised to meet the surging demand for high data rates. Achieving precise synchronization across diverse base stations…

Multiagent Systems · Computer Science 2025-04-08 Debjani Goswami , Indrakshi Dey , Nicola Marchetti , Suvra Sekhar Das

Genome sequence analysis, which examines the DNA sequences of organisms, drives advances in many critical medical and biotechnological fields. Given its importance and the exponentially growing volumes of genomic sequence data, there are…

Modern cloud databases present scaling as a binary decision: scale-out by adding nodes or scale-up by increasing per-node resources. This one-dimensional view is limiting because database performance, cost, and coordination overhead emerge…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-05 Shahir Abdullah , Syed Rohit Zaman

The exponential increase in storage demand and low lifespan of data storage devices has resulted in long-term archival and preservation emerging as a critical bottlenecks in data storage. In order to meet this demand, researchers are now…

Image and Video Processing · Electrical Eng. & Systems 2025-05-22 Xavier Pic , Raja Appuswamy

Online statistical inference facilitates real-time analysis of sequentially collected data, making it different from traditional methods that rely on static datasets. This paper introduces a novel approach to online inference in…

Machine Learning · Statistics 2025-02-27 Ruijian Han , Lan Luo , Yuanhang Luo , Yuanyuan Lin , Jian Huang

Graph anomaly detection (GAD) aims to identify nodes that deviate from normal patterns in structure or features. While recent GNN-based approaches have advanced this task, they struggle with two major challenges: 1) homophily disparity,…

Machine Learning · Computer Science 2026-03-10 Yunhui Liu , Qizhuo Xie , Yinfeng Chen , Xudong Jin , Tao Zheng , Bin Chong , Tieke He

Parallel split learning (PSL) suffers from two intertwined issues: the effective batch size grows with the number of clients, and data that is not identically and independently distributed (non-IID) skews global batches. We present parallel…

Machine Learning · Computer Science 2026-03-06 Mohammad Kohankhaki , Ahmad Ayad , Mahdi Barhoush , Anke Schmeink

Federated learning (FL) scenarios inherently generate a large communication overhead by frequently transmitting neural network updates between clients and server. To minimize the communication cost, introducing sparsity in conjunction with…

Machine Learning · Computer Science 2022-04-12 Daniel Becking , Heiner Kirchhoffer , Gerhard Tech , Paul Haase , Karsten Müller , Heiko Schwarz , Wojciech Samek

Streaming ASR with strict latency constraints is required in many speech recognition applications. In order to achieve the required latency, streaming ASR models sacrifice accuracy compared to non-streaming ASR models due to lack of future…

Computation and Language · Computer Science 2022-03-30 Jay Mahadeokar , Yangyang Shi , Ke Li , Duc Le , Jiedan Zhu , Vikas Chandra , Ozlem Kalinli , Michael L Seltzer

Pedigree GWAS (Option 29) in the current version of the Mendel software is an optimized subroutine for performing large scale genome-wide QTL analysis. This analysis (a) works for random sample data, pedigree data, or a mix of both, (b) is…

Applications · Statistics 2014-08-01 Hua Zhou , Jin Zhou , Tao Hu , Eric M Sobel , Kenneth Lange
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