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Medical deep learning models depend heavily on domain-specific knowledge to perform well on knowledge-intensive clinical tasks. Prior work has primarily leveraged unimodal knowledge graphs, such as the Unified Medical Language System…

Artificial Intelligence · Computer Science 2025-05-26 Xiaochen Wang , Yuan Zhong , Lingwei Zhang , Lisong Dai , Ting Wang , Fenglong Ma

Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Junzhi Ning , Jiashi Lin , Yingying Fang , Wei Li , Jiyao Liu , Cheng Tang , Chenglong Ma , Wenhao Tang , Tianbin Li , Ziyan Huang , Guang Yang , Junjun He

Understanding and continuously refining multimodal molecular knowledge is crucial for advancing biomedicine, chemistry, and materials science. Molecule language models (MoLMs) have become powerful tools in these domains, integrating…

Machine Learning · Computer Science 2025-12-01 Zhenyu Lei , Patrick Soga , Yaochen Zhu , Yinhan He , Yushun Dong , Jundong Li

Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and…

As real-world knowledge continues to evolve, the parametric knowledge acquired by multimodal models during pretraining becomes increasingly difficult to remain consistent with real-world knowledge. Existing research on multimodal knowledge…

Computation and Language · Computer Science 2026-03-17 Baochen Fu , Yuntao Du , Cheng Chang , Baihao Jin , Wenzhi Deng , Muhao Xu , Hongmei Yan , Weiye Song , Yi Wan

Knowledge editing enables multimodal large language models (MLLMs) to efficiently update outdated or incorrect information. However, existing benchmarks primarily emphasize cognitive-level modifications while lacking a focus on deeper…

Artificial Intelligence · Computer Science 2025-09-09 Zhaoyu Fan , Kaihang Pan , Mingze Zhou , Bosheng Qin , Juncheng Li , Shengyu Zhang , Wenqiao Zhang , Siliang Tang , Fei Wu , Yueting Zhuang

Large Language Models (LLMs) have shown extraordinary capabilities in understanding and generating text that closely mirrors human communication. However, a primary limitation lies in the significant computational demands during training,…

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark…

Multimodal Large Language Models (MLLMs) have tremendous potential to improve the accuracy, availability, and cost-effectiveness of healthcare by providing automated solutions or serving as aids to medical professionals. Despite promising…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Mohammad Shahab Sepehri , Zalan Fabian , Maryam Soltanolkotabi , Mahdi Soltanolkotabi

The scarcity of high-quality data remains a primary bottleneck in adapting multimodal generative models for medical image editing. Existing medical image editing datasets often suffer from limited diversity, neglect of medical image…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Yongfan Lai , Wen Qian , Bo Liu , Hongyan Li , Hao Luo , Fan Wang , Bohan Zhuang , Shenda Hong

Several studies showed that Large Language Models (LLMs) can answer medical questions correctly, even outperforming the average human score in some medical exams. However, to our knowledge, no study has been conducted to assess the ability…

Computation and Language · Computer Science 2025-01-03 Asma Ben Abacha , Wen-wai Yim , Yujuan Fu , Zhaoyi Sun , Meliha Yetisgen , Fei Xia , Thomas Lin

Multimodal Large Language Models (MLLMs) have demonstrated impressive capabilities in understanding common visual elements, largely due to their large-scale datasets and advanced training strategies. However, their effectiveness in medical…

Multimodal Large Language Model (MLLM) relies on the powerful LLM to perform multimodal tasks, showing amazing emergent abilities in recent studies, such as writing poems based on an image. However, it is difficult for these case studies to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Chaoyou Fu , Peixian Chen , Yunhang Shen , Yulei Qin , Mengdan Zhang , Xu Lin , Jinrui Yang , Xiawu Zheng , Ke Li , Xing Sun , Yunsheng Wu , Rongrong Ji , Caifeng Shan , Ran He

In this paper, we focus on editing Multimodal Large Language Models (MLLMs). Compared to editing single-modal LLMs, multimodal model editing is more challenging, which demands a higher level of scrutiny and careful consideration in the…

Computation and Language · Computer Science 2024-04-19 Siyuan Cheng , Bozhong Tian , Qingbin Liu , Xi Chen , Yongheng Wang , Huajun Chen , Ningyu Zhang

Large language models (LLMs) show significant potential in healthcare, prompting numerous benchmarks to evaluate their capabilities. However, concerns persist regarding the reliability of these benchmarks, which often lack clinical…

Computation and Language · Computer Science 2026-04-30 Wenting Chen , Guo Yu , Yiu-Fai Cheung , Meidan Ding , Jie Liu , Zizhan Ma , Wenxuan Wang , Linlin Shen

Multimodal large language models have advanced rapidly, but their adoption in medicine is constrained by limited domain coverage, imperfect modality alignment, and insufficient grounded reasoning. We introduce MedMO, a medical multimodal…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ankan Deria , Komal Kumar , Adinath Madhavrao Dukre , Eran Segal , Salman Khan , Imran Razzak

Multimodal large language models (MLLMs), which integrate language and visual cues for problem-solving, are crucial for advancing artificial general intelligence (AGI). However, current benchmarks for measuring the intelligence of MLLMs…

The dynamic nature of information necessitates continuously updating large vision-language models (LVLMs). While recent knowledge editing techniques hint at promising directions, they often focus on editing a single modality (vision or…

Machine Learning · Computer Science 2025-10-31 Jin Seong , Jiyun Park , Wencke Liermann , Hongseok Choi , Yoonji Nam , Hyun Kim , Soojong Lim , Namhoon Lee

Ensuring the general efficacy and goodness for human beings from medical large language models (LLM) before real-world deployment is crucial. However, a widely accepted and accessible evaluation process for medical LLM, especially in the…

Multimodal Large Language Models (MLLM) have made significant progress in the field of document analysis. Despite this, existing benchmarks typically focus only on extracting text and simple layout information, neglecting the complex…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Lei Chen , Feng Yan , Yujie Zhong , Shaoxiang Chen , Zequn Jie , Lin Ma