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Tool use has turned large language models (LLMs) into powerful agents that can perform complex multi-step tasks by dynamically utilising external software components. However, these tools must be implemented in advance by human developers,…

Computation and Language · Computer Science 2025-06-02 Georg Wölflein , Dyke Ferber , Daniel Truhn , Ognjen Arandjelović , Jakob Nikolas Kather

LLM-based reasoning models have enabled the development of agentic systems that act as co-scientists, assisting in multi-step scientific analysis. However, evaluating these systems is challenging, as it requires realistic, end-to-end…

Machine Learning · Computer Science 2026-02-24 Siba Smarak Panigrahi , Jovana Videnović , Maria Brbić

As large language models (LLMs) become more specialized, we envision a future where millions of expert LLMs exist, each trained on proprietary data and excelling in specific domains. In such a system, answering a query requires selecting a…

Large Language Models (LLMs) have demonstrated impressive performance across diverse domains, yet they still encounter challenges such as insufficient domain-specific knowledge, biases, and hallucinations. This underscores the need for…

Computation and Language · Computer Science 2025-04-07 Hongliu Cao , Ilias Driouich , Robin Singh , Eoin Thomas

Future sixth-generation (6G) mobile networks are envisioned to be equipped with a diverse set of powerful, yet highly specialized, optimization experts. Such a promising vision is concurrently expected to give rise to the need for scalable…

Machine Learning · Computer Science 2026-05-06 Robert-Jeron Reifert , Alaa Alameer Ahmad , Hayssam Dahrouj , Aydin Sezgin

Large Language Model (LLM)-based agents have demonstrated strong capabilities across a wide range of tasks, and their application in the medical domain holds particular promise due to the demand for high generalizability and reliance on…

Artificial Intelligence · Computer Science 2025-08-18 Yangyang Zhuang , Wenjia Jiang , Jiayu Zhang , Ze Yang , Joey Tianyi Zhou , Chi Zhang

Agentic systems for drug discovery have demonstrated autonomous synthesis planning, literature mining, and molecular design. We ask how well they generalize. Evaluating six frameworks against 15 task classes drawn from peptide therapeutics,…

Quantitative Methods · Quantitative Biology 2026-02-12 Edward Wijaya

The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule…

Biomolecules · Quantitative Biology 2025-04-01 Bowen Gao , Yanwen Huang , Yiqiao Liu , Wenxuan Xie , Wei-Ying Ma , Ya-Qin Zhang , Yanyan Lan

In an era where vast amounts of data are collected and processed from diverse sources, there is a growing demand for sophisticated AI systems capable of intelligently fusing and analyzing this information. To address these challenges,…

Software Engineering · Computer Science 2025-11-24 Amine Ben Hassouna , Hana Chaari , Ines Belhaj

Autonomous materials research systems allow scientists to fail smarter, learn faster, and spend less resources in their studies. As these systems grow in number, capability, and complexity, a new challenge arises - how will they work…

Multiagent Systems · Computer Science 2023-03-21 A. Gilad Kusne , Austin McDannald

The automation of scientific discovery represents a critical milestone in Artificial Intelligence (AI) research. However, existing agentic systems for science suffer from two fundamental limitations: rigid, pre-programmed workflows that…

Artificial Intelligence · Computer Science 2025-10-20 Ed Li , Junyu Ren , Xintian Pan , Cat Yan , Chuanhao Li , Dirk Bergemann , Zhuoran Yang

Exploratory analysis of high-dimensional data relies on embedding the data into a low-dimensional space (typically 2D or 3D), based on which visualization plot is produced to uncover meaningful structures and to communicate geometric and…

Human-Computer Interaction · Computer Science 2026-04-23 Burak Susam , Tingting Mu

Computational materials science and chemistry span vast knowledge domains and fractured software ecosystems. Although large language models (LLMs) have demonstrated research capabilities, scaling monolithic agents to manage the rigor and…

Recent advances in AI and ML have transformed data science, yet increasing complexity and expertise requirements continue to hinder progress. Although crowd-sourcing platforms alleviate some challenges, high-level machine learning…

Artificial intelligence is reshaping scientific exploration, but most methods automate procedural tasks without engaging in scientific reasoning, limiting autonomy in discovery. We introduce Materials Agents for Simulation and Theory in…

With the integration of massive distributed energy resources and the widespread participation of novel market entities, the operation of active distribution networks (ADNs) is progressively evolving into a complex multi-scenario,…

Systems and Control · Electrical Eng. & Systems 2025-11-18 Xu Yang , Chenhui Lin , Haotian Liu , Qi Wang , Yue Yang , Wenchuan Wu

Configuring LLM-based agent systems involves choosing workflows, tools, token budgets, and prompts from a large combinatorial design space, and is typically handled today by fixed templates or hand-tuned heuristics that apply the same…

Artificial Intelligence · Computer Science 2026-05-22 Aditya Taparia , Som Sagar , Ransalu Senanayake

Large language models (LLMs) and their associated agent-based frameworks have significantly advanced automated information extraction, a critical component of modern recommender systems. While these multitask frameworks are widely used in…

Information Retrieval · Computer Science 2025-07-28 Blaž Škrlj , Benoît Guilleminot , Andraž Tori

Large language models (LLMs) are becoming increasingly applied beyond natural language processing, demonstrating strong capabilities in complex scientific tasks that traditionally require human expertise. This progress has extended into…

Materials Science · Physics 2026-02-26 Dong Hyeon Mok , Seoin Back , Victor Fung , Guoxiang Hu

AI agent development relies heavily on natural language prompting to define agents' tasks, knowledge, and goals. These prompts are interpreted by Large Language Models (LLMs), which govern agent behavior. Consequently, agentic performance…

Artificial Intelligence · Computer Science 2026-04-14 Roi Ben-Gigi , Yuval David , Fabiana Fournier , Lior Limonad , Dany Moshkovich , Hadar Mulian , Segev Shlomov