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Cardiac digital twins (CDTs) are personalized virtual representations used to understand complex cardiac mechanisms. A critical component of CDT development is solving the ECG inverse problem, which enables the reconstruction of cardiac…

Computer Vision and Pattern Recognition · Computer Science 2024-09-16 Lei Li , Julia Camps , Blanca Rodriguez , Vicente Grau

Synthetic electrocardiogram generation serves medical AI applications requiring privacy-preserving data sharing and training dataset augmentation. Current diffusion-based methods achieve high generation quality but require hundreds of…

Signal Processing · Electrical Eng. & Systems 2025-09-16 Vitalii Bondar , Serhii Semenov , Vira Babenko , Dmytro Holovniak

Electrocardiogram (ECG) is a widely used non-invasive diagnostic tool for heart diseases. Many studies have devised ECG analysis models (e.g., classifiers) to assist diagnosis. As an upstream task, researches have built generative models to…

Machine Learning · Computer Science 2023-05-30 Jintai Chen , Kuanlun Liao , Kun Wei , Haochao Ying , Danny Z. Chen , Jian Wu

Electroencephalography (EEG) is a widely used, non-invasive method for capturing brain activity, and is particularly relevant for applications in Brain-Computer Interfaces (BCI). However, collecting high-quality EEG data remains a major…

Signal Processing · Electrical Eng. & Systems 2025-10-22 Henrique de Lima Alexandre , Clodoaldo Aparecido de Moraes Lima

Synthetic data generation represents a significant advancement in boosting the performance of machine learning (ML) models, particularly in fields where data acquisition is challenging, such as echocardiography. The acquisition and labeling…

Machine Learning · Computer Science 2025-08-28 Nima Kondori , Hanwen Liang , Hooman Vaseli , Bingyu Xie , Christina Luong , Purang Abolmaesumi , Teresa Tsang , Renjie Liao

In recent years, significant progress has been made in the development of text-to-image generation models. However, these models still face limitations when it comes to achieving full controllability during the generation process. Often,…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Salaheldin Mohamed

Electronic health records (EHR) contain a wealth of biomedical information, serving as valuable resources for the development of precision medicine systems. However, privacy concerns have resulted in limited access to high-quality and…

Machine Learning · Computer Science 2024-03-26 Hongyi Yuan , Songchi Zhou , Sheng Yu

High failure rates in cardiac drug development necessitate virtual clinical trials via electrocardiogram (ECG) generation to reduce risks and costs. However, existing ECG generation models struggle to balance morphological realism with…

Machine Learning · Computer Science 2026-03-31 Qian Shao , Bang Du , Zepeng Li , Qiyuan Chen , Jiahe Chen , Hongxia Xu , Jimeng Sun , Jian Wu , Jintai Chen

Due to patient privacy protection concerns, machine learning research in healthcare has been undeniably slower and limited than in other application domains. High-quality, realistic, synthetic electronic health records (EHRs) can be…

Machine Learning · Computer Science 2023-02-10 Huan He , Shifan Zhao , Yuanzhe Xi , Joyce C Ho

Electronic health records (EHRs) are a pivotal data source that enables numerous applications in computational medicine, e.g., disease progression prediction, clinical trial design, and health economics and outcomes research. Despite wide…

Machine Learning · Computer Science 2024-06-18 Jun Han , Zixiang Chen , Yongqian Li , Yiwen Kou , Eran Halperin , Robert E. Tillman , Quanquan Gu

Diffusion models have enabled remarkably high-quality medical image generation, yet it is challenging to enforce anatomical constraints in generated images. To this end, we propose a diffusion model-based method that supports…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Nicholas Konz , Yuwen Chen , Haoyu Dong , Maciej A. Mazurowski

Electrocardiogram (ECG) synthesis is the area of research focused on generating realistic synthetic ECG signals for medical use without concerns over annotation costs or clinical data privacy restrictions. Traditional ECG generation models…

Computation and Language · Computer Science 2023-03-17 Hyunseung Chung , Jiho Kim , Joon-myoung Kwon , Ki-Hyun Jeon , Min Sung Lee , Edward Choi

Electronic health records (EHRs) are invaluable for clinical research, yet privacy concerns severely restrict data sharing. Synthetic data generation offers a promising solution, but EHRs present unique challenges: they contain both…

Machine Learning · Computer Science 2026-03-26 Shaonan Liu , Yuichiro Iwashita , Soichiro Nakako , Masakazu Iwamura , Koichi Kise

Processing temporal sequences is central to a variety of applications in health care, and in particular multi-channel Electrocardiogram (ECG) is a highly prevalent diagnostic modality that relies on robust sequence modeling. While Recurrent…

Machine Learning · Statistics 2018-07-17 Deepta Rajan , Jayaraman J. Thiagarajan

Electroencephalography (EEG) plays a significant role in the Brain Computer Interface (BCI) domain, due to its non-invasive nature, low cost, and ease of use, making it a highly desirable option for widespread adoption by the general…

Signal Processing · Electrical Eng. & Systems 2023-03-13 Giulio Tosato , Cesare M. Dalbagno , Francesco Fumagalli

Electrical waves in the heart form rotating spiral or scroll waves during life-threatening arrhythmias such as atrial or ventricular fibrillation. The wave dynamics are typically modeled using coupled partial differential equations, which…

Medical Physics · Physics 2024-10-07 Tanish Baranwal , Jan Lebert , Jan Christoph

In this work, we propose a denoising diffusion generative model (DDGM) trained with healthy electrocardiogram (ECG) data that focuses on ECG morphology and inter-lead dependence. Our results show that this innovative generative model can…

Signal Processing · Electrical Eng. & Systems 2024-01-12 Gabriel V. Cardoso , Lisa Bedin , Josselin Duchateau , Rémi Dubois , Eric Moulines

Eligibility criteria (EC) are essential for clinical trial design, yet drafting them remains a time-intensive and cognitively demanding task for clinicians. Existing automated approaches often fall at two extremes either requiring highly…

Artificial Intelligence · Computer Science 2026-02-03 Trisha Das , Katherine Kero , Dorinda Schumann , Tracy Ohrt , Sanjit Singh Batra , Gregory D Lyng , Robert E. Tillman

In human-centric content generation, the pre-trained text-to-image models struggle to produce user-wanted portrait images, which retain the identity of individuals while exhibiting diverse expressions. This paper introduces our efforts…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Renshuai Liu , Bowen Ma , Wei Zhang , Zhipeng Hu , Changjie Fan , Tangjie Lv , Yu Ding , Xuan Cheng

Echocardiography is routine for cardiac examination. However, 2D ultrasound (US) struggles with accurate metric calculation and direct observation of 3D cardiac structures. Moreover, 3D US is limited by low resolution, small field of view…