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Deep neural networks are known to be data-driven and label noise can have a marked impact on model performance. Recent studies have shown great robustness to classic image recognition even under a high noisy rate. In medical applications,…

Computer Vision and Pattern Recognition · Computer Science 2021-03-23 Lie Ju , Xin Wang , Lin Wang , Dwarikanath Mahapatra , Xin Zhao , Mehrtash Harandi , Tom Drummond , Tongliang Liu , Zongyuan Ge

The task of image segmentation is inherently noisy due to ambiguities regarding the exact location of boundaries between anatomical structures. We argue that this information can be extracted from the expert annotations at no extra cost,…

Computer Vision and Pattern Recognition · Computer Science 2021-04-14 Mobarakol Islam , Ben Glocker

Computational models providing accurate estimates of their uncertainty are crucial for risk management associated with decision making in healthcare contexts. This is especially true since many state-of-the-art systems are trained using the…

Machine Learning · Computer Science 2022-06-09 Hongshu Liu , Nabeel Seedat , Julia Ive

An open scientific challenge is how to classify events with reliable measures of uncertainty, when we have a mechanistic model of the data-generating process but the distribution over both labels and latent nuisance parameters is different…

Machine Learning · Statistics 2024-07-02 Luca Masserano , Alex Shen , Michele Doro , Tommaso Dorigo , Rafael Izbicki , Ann B. Lee

Label Smoothing (LS) improves model generalization through penalizing models from generating overconfident output distributions. For each training sample the LS strategy smooths the one-hot encoded training signal by distributing its…

Machine Learning · Computer Science 2021-06-29 Hongyu Guo

We study Label Smoothing (LS), a widely used regularization technique, in the context of neural learning to rank (L2R) models. LS combines the ground-truth labels with a uniform distribution, encouraging the model to be less confident in…

Information Retrieval · Computer Science 2020-12-17 Gustavo Penha , Claudia Hauff

Medical image segmentation is inherently uncertain. For a given image, there may be multiple plausible segmentation hypotheses, and physicians will often disagree on lesion and organ boundaries. To be suited to real-world application,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 João Lourenço Silva , Arlindo L. Oliveira

Medical image-language pre-training aims to align medical images with clinically relevant text to improve model performance on various downstream tasks. However, existing models often struggle with the variability and ambiguity inherent in…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Shreyank N Gowda , Ruichi Zhang , Xiao Gu , Ying Weng , Lu Yang

Accurately quantifying uncertainty in large language models (LLMs) is crucial for their reliable deployment, especially in high-stakes applications. Current state-of-the-art methods for measuring semantic uncertainty in LLMs rely on strict…

Machine Learning · Computer Science 2024-10-31 Yashvir S. Grewal , Edwin V. Bonilla , Thang D. Bui

Bootstrapping labels from radiology reports has become the scalable alternative to provide inexpensive ground truth for medical imaging. Because of the domain specific nature, state-of-the-art report labeling tools are predominantly…

Computation and Language · Computer Science 2019-10-03 Tobi Olatunji , Li Yao

Explainable disease diagnosis, which leverages patient information (e.g., signs and symptoms) and computational models to generate probable diagnoses and reasonings, offers clear clinical values. However, when clinical notes encompass…

Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 An Yan , Yu Wang , Yiwu Zhong , Zexue He , Petros Karypis , Zihan Wang , Chengyu Dong , Amilcare Gentili , Chun-Nan Hsu , Jingbo Shang , Julian McAuley

Deep learning models, especially convolutional neural networks, have achieved impressive results in medical image classification. However, these models often produce overconfident predictions, which can undermine their reliability in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Kushan Choudhury , Shubhrodeep Roy , Ankur Chanda , Shubhajit Biswas , Somenath Kuiry

Medical imaging plays a pivotal role in diagnosis and treatment in clinical practice. Inspired by the significant progress in automatic image captioning, various deep learning (DL)-based methods have been proposed to generate radiology…

Computer Vision and Pattern Recognition · Computer Science 2022-02-04 Yixin Wang , Zihao Lin , Zhe Xu , Haoyu Dong , Jiang Tian , Jie Luo , Zhongchao Shi , Yang Zhang , Jianping Fan , Zhiqiang He

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Label Smoothing (LS) is an effective regularizer to improve the generalization of state-of-the-art deep models. For each training sample the LS strategy smooths the one-hot encoded training signal by distributing its distribution mass over…

Machine Learning · Computer Science 2020-12-04 Hongyu Guo

Deep Learning sets the state-of-the-art in many challenging tasks showing outstanding performance in a broad range of applications. Despite its success, it still lacks robustness hindering its adoption in medical applications. Modeling…

Computer Vision and Pattern Recognition · Computer Science 2019-09-19 Agnieszka Tomczack , Nassir Navab , Shadi Albarqouni

Recent advances in natural language processing (NLP) have opened up greater opportunities to enable fine-tuned large language models (LLMs) to behave as more powerful interactive agents through improved instruction-following ability.…

Machine Learning · Computer Science 2025-10-27 Jerry Huang , Peng Lu , Qiuhao Zeng

Computer-aided diagnosis systems must make critical decisions from medical images that are often noisy, ambiguous, or conflicting, yet today's models are trained on overly simplistic labels that ignore diagnostic uncertainty. One-hot labels…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Ang Nan Gu , Michael Tsang , Hooman Vaseli , Purang Abolmaesumi , Teresa Tsang

Learning from noisy labels remains a major challenge in medical image analysis, where annotation demands expert knowledge and substantial inter-observer variability often leads to inconsistent or erroneous labels. Despite extensive research…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Yuan Ma , Junlin Hou , Chao Zhang , Yukun Zhou , Zongyuan Ge , Haoran Xie , Lie Ju
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