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Quantum Variational Circuits (QVCs) are often claimed as one of the most potent uses of both near term and long term quantum hardware. The standard approaches to optimizing these circuits rely on a classical system to compute the new…

Quantum Physics · Physics 2022-02-11 Owen Lockwood

Variational quantum algorithms (VQAs) provide a promising approach to achieve quantum advantage in the noisy intermediate-scale quantum era. In this era, quantum computers experience high error rates and quantum error detection and…

Emerging Technologies · Computer Science 2021-09-07 Salonik Resch , Anthony Gutierrez , Joon Suk Huh , Srikant Bharadwaj , Yasuko Eckert , Gabriel Loh , Mark Oskin , Swamit Tannu

Lattices are very important objects in the effort to construct cryptographic primitives that are secure against quantum attacks. A central problem in the study of lattices is that of finding the shortest non-zero vector in the lattice.…

Quantum Physics · Physics 2022-09-05 Nishant Rodrigues , Brad Lackey

Variational quantum algorithms are expected to demonstrate the advantage of quantum computing on near-term noisy quantum computers. However, training such variational quantum algorithms suffers from gradient vanishing as the size of the…

Quantum Physics · Physics 2021-11-30 Anbang Wu , Gushu Li , Yuke Wang , Boyuan Feng , Yufei Ding , Yuan Xie

Quantum computing has gained a lot of attention recently, and scientists have seen potential applications in this field using quantum computing for Cryptography and Communication to Machine Learning and Healthcare. Protein folding has been…

Quantum Physics · Physics 2022-11-16 Hasan Mustafa , Sai Nandan Morapakula , Prateek Jain , Srinjoy Ganguly

Quantum computers are exponentially faster than their classical counterparts in terms of solving some specific, but important problems. The biggest challenge in realizing a quantum computing system is the environmental noise. One way to…

Emerging Technologies · Computer Science 2014-12-30 Mohammad Javad Dousti , Massoud Pedram

Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

Modeling and simulating the protein folding process overall remains a grand challenge in computational biology. We systematically investigate end-to-end quantum algorithms for simulating various protein dynamics with effects, such as…

Quantum Physics · Physics 2025-04-17 Zhenning Liu , Xiantao Li , Chunhao Wang , Jin-Peng Liu

Modelling and predicting protein configurations is crucial for advancing drug discovery, enabling the design of treatments for life-threatening diseases. A critical aspect of this challenge is rotamer optimisation - the determination of…

Quantum Physics · Physics 2025-07-28 Anastasia Agathangelou , Dilhan Manawadu , Ivano Tavernelli

Bayesian network structure learning is an NP-hard problem that has been faced by a number of traditional approaches in recent decades. Currently, quantum technologies offer a wide range of advantages that can be exploited to solve…

Quantum Physics · Physics 2022-03-07 Vicente P. Soloviev , Concha Bielza , Pedro Larrañaga

Solving non-Hermitian quantum many-body systems on a quantum computer by minimizing the variational energy is challenging as the energy can be complex. Here, based on energy variance, we propose a variational method for solving the…

Quantum Physics · Physics 2024-02-21 Xu-Dan Xie , Zheng-Yuan Xue , Dan-Bo Zhang

We introduce a novel quantum algorithm for the lattice Boltzmann method (LBM) based on the one-step simplified LBM. The structure of the algorithm allows for more flexibility in modelling different physics in contrast to earlier quantum…

Quantum computing promises the possibility of studying the real-time dynamics of nonperturbative quantum field theories while avoiding the sign problem that obstructs conventional lattice approaches. Current and near-future quantum devices…

High Energy Physics - Lattice · Physics 2021-12-15 Christopher Culver , David Schaich

Variational quantum algorithms are of special importance in the research on quantum computing applications because of their applicability to current Noisy Intermediate-Scale Quantum (NISQ) devices. The main building blocks of these…

Variational quantum algorithms (VQAs) are expected to be a path to quantum advantages on noisy intermediate-scale quantum devices. However, both empirical and theoretical results exhibit that the deployed ansatz heavily affects the…

Quantum Physics · Physics 2022-05-31 Yuxuan Du , Tao Huang , Shan You , Min-Hsiu Hsieh , Dacheng Tao

This manuscript explores a variational quantum formulation for nonlinear elasticity problems arising from hyperelastic material models, targeting near term noisy intermediate scale quantum (NISQ) devices. The approach leverages the…

Quantum Physics · Physics 2026-05-29 Uditnarayan Kouskiya , Caglar Oskay

Variational quantum algorithms are a leading candidate for early applications on noisy intermediate-scale quantum computers. These algorithms depend on a classical optimization outer-loop that minimizes some function of a parameterized…

In this study, we propose a new method for constrained combinatorial optimization using variational quantum circuits. Quantum computers are considered to have the potential to solve large combinatorial optimization problems faster than…

Quantum Physics · Physics 2025-07-15 Hyakka Nakada , Kotaro Tanahashi , Shu Tanaka

In recent years, quantum, quantum-inspired, and hybrid algorithms are increasingly showing promise for solving software engineering optimization problems. However, best-intended practices for conducting empirical studies have not yet well…

Software Engineering · Computer Science 2025-11-03 Man Zhang , Yuechen Li , Tao Yue , Kai-Yuan Cai

Quantum computers are inherently affected by noise. While in the long-term error correction codes will account for noise at the cost of increasing physical qubits, in the near-term the performance of any quantum algorithm should be tested…