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3D reconstruction of the fiber connectivity of the rat brain at microscopic scale enables gaining detailed insight about the complex structural organization of the brain. We introduce a new method for registration and 3D reconstruction of…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Sharib Ali , Martin Schober , Philipp Schlöme , Katrin Amunts , Markus Axer , Karl Rohr

Brain morphometry from magnetic resonance imaging (MRI) is a consolidated biomarker for many neurodegenerative diseases. Recent advances in this domain indicate that deep convolutional neural networks can infer morphometric measurements…

Image and Video Processing · Electrical Eng. & Systems 2020-09-09 Rodrigo Santa Cruz , Léo Lebrat , Pierrick Bourgeat , Vincent Doré , Jason Dowling , Jurgen Fripp , Clinton Fookes , Olivier Salvado

Inferring the exact parameters of a neural network with only query access is an NP-Hard problem, with few practical existing algorithms. Solutions would have major implications for security, verification, interpretability, and understanding…

Machine Learning · Computer Science 2024-10-01 Judah Goldfeder , Quinten Roets , Gabe Guo , John Wright , Hod Lipson

Structural connectivity in the brain is typically studied by reducing its observation to a single spatial resolution. However, the brain possesses a rich architecture organized over multiple scales linked to one another. We explored the…

Physics and Society · Physics 2020-09-07 Muhua Zheng , Antoine Allard , Patric Hagmann , Yasser Alemán-Gómez , M. Ángeles Serrano

The human brains are organized into hierarchically modular networks facilitating efficient and stable information processing and supporting diverse cognitive processes during the course of development. While the remarkable reconfiguration…

Neurons and Cognition · Quantitative Biology 2020-09-16 Xuyun Wen , Liming Hsu , Weili Lin , Han Zhang , Dinggang Shen

Despite impressive performance on numerous visual tasks, Convolutional Neural Networks (CNNs) --- unlike brains --- are often highly sensitive to small perturbations of their input, e.g. adversarial noise leading to erroneous decisions. We…

Based on the data of the NIH-funded Human Connectome Project, we have computed structural connectomes of 426 human subjects in five different resolutions of 83, 129, 234, 463 and 1015 nodes and several edge weights. The graphs are given in…

Neurons and Cognition · Quantitative Biology 2016-10-07 Csaba Kerepesi , Balazs Szalkai , Balint Varga , Vince Grolmusz

This work is centred around the recently proposed product key memory structure \cite{large_memory}, implemented for a number of computer vision applications. The memory structure can be regarded as a simple computation primitive suitable to…

Computer Vision and Pattern Recognition · Computer Science 2021-04-27 Rasul Karimov , Yury Malkov , Karim Iskakov , Victor Lempitsky

Brain metastases are a common complication of systemic cancer, affecting over 20% of patients with primary malignancies. Longitudinal magnetic resonance imaging (MRI) is essential for diagnosing patients, tracking disease progression,…

Modern scientific fields face the challenge of integrating a wealth of data, analyses, and results. We recently showed that a neglect of this integration can lead to circular analyses and redundant explanations. Here, we help advance…

Neurons and Cognition · Quantitative Biology 2025-08-15 Mika Rubinov

The meninges, located between the skull and brain, are composed of three membrane layers: the pia, the arachnoid, and the dura. Reconstruction of these layers can aid in studying volume differences between patients with neurodegenerative…

Image and Video Processing · Electrical Eng. & Systems 2023-04-14 Peiyu Duan , Yuan Xue , Shuo Han , Lianrui Zuo , Aaron Carass , Caitlyn Bernhard , Savannah Hays , Peter A. Calabresi , Susan M. Resnick , James S. Duncan , Jerry L. Prince

Automated segmentation of anatomical sub-regions with high precision has become a necessity to enable the quantification and characterization of cells/ tissues in histology images. Currently, a machine learning model to analyze…

Image and Video Processing · Electrical Eng. & Systems 2023-06-05 Hosein Barzekar , Hai Ngu , Han Hui Lin , Mohsen Hejrati , Steven Ray Valdespino , Sarah Chu , Baris Bingol , Somaye Hashemifar , Soumitra Ghosh

Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…

Quantitative Methods · Quantitative Biology 2021-03-22 Tamal Batabyal , Aijaz Ahmad Naik , Daniel Weller , Jaideep Kapur

Classification of biological neuron types and networks poses challenges to the full understanding of the brain's organisation and functioning. In this paper, we develop a novel objective classification model of biological neuronal types and…

Neurons and Cognition · Quantitative Biology 2020-03-31 Michael Taynnan Barros , Harun Siljak , Peter Mullen , Constantinos Papadias , Jari Hyttinen , Nicola Marchetti

Despite the rapid progress of neuromorphic computing, the inadequate depth and the resulting insufficient representation power of spiking neural networks (SNNs) severely restrict their application scope in practice. Residual learning and…

Neural and Evolutionary Computing · Computer Science 2022-02-18 Yifan Hu , Yujie Wu , Lei Deng , Guoqi Li

The exponential growth of neuroscience literature presents a significant challenge for researchers seeking to efficiently access and utilize relevant information. To address this issue, we introduce the Brain Knowledge Engine (BrainKnow),…

Digital Libraries · Computer Science 2024-06-07 Cunqing Huangfu , Kang Sun , Yi Zeng , Yuwei Wang , Dongsheng Wang , Zizhe Ruan

Accurate compensation of brain deformation is a critical challenge for reliable image-guided neurosurgery, as surgical manipulation and tumor resection induce tissue motion that misaligns preoperative planning images with intraoperative…

The wiring diagram of the mouse brain has recently been mapped at a mesoscopic scale in the Allen Mouse Brain Connectivity Atlas. Axonal projections from brain regions were traced using green fluoresent proteins. The resulting data were…

Neurons and Cognition · Quantitative Biology 2018-12-24 Pascal Grange

Semantic segmentation of neuronal structures in 3D high-resolution fluorescence microscopy imaging of the human brain cortex can take advantage of bidimensional CNNs, which yield good results in neuron localization but lead to inaccurate…

Image and Video Processing · Electrical Eng. & Systems 2020-09-03 Filippo Maria Castelli , Matteo Roffilli , Giacomo Mazzamuto , Irene Costantini , Ludovico Silvestri , Francesco Saverio Pavone

Accurate segmentation and classification of brain tumors from Magnetic Resonance Imaging (MRI) remain key challenges in medical image analysis, primarily due to the lack of high-quality, balanced, and diverse datasets with expert…

Image and Video Processing · Electrical Eng. & Systems 2026-01-29 Amirreza Fateh , Yasin Rezvani , Sara Moayedi , Sadjad Rezvani , Fatemeh Fateh , Mansoor Fateh , Vahid Abolghasemi