Related papers: Frequency-Domain Denoising-Based in Vivo Fluoresce…
Compared to imaging in the visible and near-infrared regions below 900 nm, imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo mainly due to the…
In vivo real-time epifluorescence imaging of mouse hindlimb vasculatures in the second near-infrared region (NIR-II, 1.1~1.4 microns) is performed using single-walled carbon nanotubes (SWNTs) as fluorophores. Both high spatial resolution…
Fluorescent imaging in the second near infrared window (NIR II, 1-1.4 {\mu}m) holds much promise due to minimal autofluorescence and tissue scattering. Here, using well functionalized biocompatible single-walled carbon nanotubes (SWNTs) as…
Addressing the issues of severe noise and high frequency structural degradation in visible images under low-light conditions, this paper proposes a Near Infrared (NIR) aided low light image restoration method based on Frequency Decoupled…
In vivo fluorescence imaging in the second near-infrared window (1.0-1.7 microns) can afford deep tissue penetration and high spatial resolution, owing to the reduced scattering of long-wavelength photons. Here, we synthesize a series of…
NIR-II fluorescence imaging provides superior tissue penetration and clarity, yet its clinical use in surgical navigation is hindered by a critical workflow issue. Surgeons must divert their attention between the operative field and…
Significance: Diffuse in-vivo Flow Cytometry (DiFC) is an emerging fluorescence sensing method to non-invasively detect labeled circulating cells in-vivo. However, due to Signal-to-Noise Ratio (SNR) constraints largely attributed to…
Low quantum yields of near infrared (NIR) fluorophores have limited their capabilities as imaging probes in a transparent, low background imaging window. Here for the first time we reported near-infrared fluorescence enhance (NIR-FE) cell…
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, offer substantial advantages for in vivo imaging, owing to their deep tissue penetration and minimal background autofluorescence. Nanoparticles incorporating…
Biosensing based on optically trapped fluorescent nanodiamonds potentially allows to resolve biochemical processes inside living cells at a desired intracellular location. Towards this goal, we investigate near infrared (NIR) laser…
Existing single-image denoising algorithms often struggle to restore details when dealing with complex noisy images. The introduction of near-infrared (NIR) images offers new possibilities for RGB image denoising. However, due to the…
Functional near-infrared spectroscopy (fNIRS) is impacted by signal contamination from superficial hemodynamics. It is important to develop methods that account for such contamination and provide accurate measurements of cerebral…
Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to…
Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising…
Patient scans from MRI often suffer from noise, which hampers the diagnostic capability of such images. As a method to mitigate such artifact, denoising is largely studied both within the medical imaging community and beyond the community…
Nitrogen-vacancy (NV) centers show great potentials for nanoscale bio-sensing and bio-imaging. Nevertheless, their envisioned bio-applications suffer from intrinsic background noise due to unavoidable light scattering and autofluorescence…
Low fluence illumination sources can facilitate clinical transition of photoacoustic imaging because they are rugged, portable, affordable, and safe. However, these sources also decrease image quality due to their low fluence. Here, we…
Despite the significant progress in image denoising, it is still challenging to restore fine-scale details while removing noise, especially in extremely low-light environments. Leveraging near-infrared (NIR) images to assist visible RGB…
Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…
Significance: This work targets the contamination of optical signals by superficial hemodynamics, which is one of the chief hurdles in non-invasive optical measurements of the human brain. Aim: To identify optimal source-detector distances…