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How can we design neural networks that allow for stable universal approximation of maps between topologically interesting manifolds? The answer is with a coordinate projection. Neural networks based on topological data analysis (TDA) use…

Machine Learning · Computer Science 2022-10-04 Michael Puthawala , Matti Lassas , Ivan Dokmanic , Pekka Pankka , Maarten de Hoop

One of the essential tasks in connectomics is the morphology analysis of neurons and organelles like mitochondria to shed light on their biological properties. However, these biological objects often have tangled parts or complex branching…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Abhimanyu Talwar , Zudi Lin , Donglai Wei , Yuesong Wu , Bowen Zheng , Jinglin Zhao , Won-Dong Jang , Xueying Wang , Jeff W. Lichtman , Hanspeter Pfister

In this paper, an innovative multi-modal deep learning model is proposed to deeply integrate heterogeneous information from medical images and clinical reports. First, for medical images, convolutional neural networks were used to extract…

Machine Learning · Computer Science 2024-05-29 Ziyan Yao , Fei Lin , Sheng Chai , Weijie He , Lu Dai , Xinghui Fei

This work presents a novel algorithm for progressively adapting neural network architecture along the depth. In particular, we attempt to address the following questions in a mathematically principled way: i) Where to add a new capacity…

Machine Learning · Computer Science 2026-03-03 C G Krishnanunni , Tan Bui-Thanh , Clint Dawson

We characterize structures such as monotonicity, convexity, and modality in smooth regression curves using persistent homology. Persistent homology is a key tool in topological data analysis that detects higher-dimensional topological…

Algebraic Topology · Mathematics 2025-10-28 Satish Kumar , Subhra Sankar Dhar

In this work, we propose a new paradigm of iterative model-based reconstruction algorithms for providing real-time solution for zooming-in and refining a region of interest in medical and clinical tomographic images. This algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Junqi Tang , Guixian Xu , Jinglai Li

AI models for drug discovery and chemical literature mining must interpret molecular images and generate outputs consistent with 3D geometry and stereochemistry. Most molecular language models rely on strings or graphs, while…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Jing Lan , Hexiao Ding , Hongzhao Chen , Yufeng Jiang , Nga-Chun Ng , Gwing Kei Yip , Gerald W. Y. Cheng , Yunlin Mao , Jing Cai , Liang-ting Lin , Jung Sun Yoo

Reconstructing models from unorganized point clouds presents a significant challenge, especially when the models consist of multiple components represented by their surface point clouds. Such models often involve point clouds with noise…

Computational Geometry · Computer Science 2025-08-26 Yu Chen , Hongwei Lin

In this paper, we propose a novel medical image segmentation using iterative deep learning framework. We have combined an iterative learning approach and an encoder-decoder network to improve segmentation results, which enables to precisely…

Computer Vision and Pattern Recognition · Computer Science 2017-08-14 Jung Uk Kim , Hak Gu Kim , Yong Man Ro

Topological data analysis (TDA) is a rapidly evolving field in applied mathematics and data science that leverages tools from topology to uncover robust, shape-driven insights in complex datasets. The main workhorse is persistent homology,…

History and Overview · Mathematics 2025-07-29 Zhe Su , Xiang Liu , Layal Bou Hamdan , Vasileios Maroulas , Jie Wu , Gunnar Carlsson , Guo-Wei Wei

The topological analysis of four-dimensional (4D) image-type data is challenged by the immense size that these datasets can reach. This can render the direct application of methods, like persistent homology and convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Khalil Mathieu Hannouch , Stephan Chalup

Implicit surface representations, such as signed-distance functions, combined with deep learning have led to impressive models which can represent detailed shapes of objects with arbitrary topology. Since a continuous function is learned,…

Computer Vision and Pattern Recognition · Computer Science 2021-02-08 Edgar Tretschk , Ayush Tewari , Vladislav Golyanik , Michael Zollhöfer , Carsten Stoll , Christian Theobalt

Contrastive learning, which aims to capture general representation from unlabeled images to initialize the medical analysis models, has been proven effective in alleviating the high demand for expensive annotations. Current methods mainly…

Computer Vision and Pattern Recognition · Computer Science 2022-08-18 Huai Chen , Renzhen Wang , Xiuying Wang , Jieyu Li , Qu Fang , Hui Li , Jianhao Bai , Qing Peng , Deyu Meng , Lisheng Wang

Assigning meaning to parts of image data is the goal of semantic image segmentation. Machine learning methods, specifically supervised learning is commonly used in a variety of tasks formulated as semantic segmentation. One of the major…

Computer Vision and Pattern Recognition · Computer Science 2021-12-20 Lu Yin , Vlado Menkovski , Shiwei Liu , Mykola Pechenizkiy

Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

Segmenting medical images is critical to facilitating both patient diagnoses and quantitative research. A major limiting factor is the lack of labeled data, as obtaining expert annotations for each new set of imaging data and task can be…

Computer Vision and Pattern Recognition · Computer Science 2024-06-27 Chen Liu , Matthew Amodio , Liangbo L. Shen , Feng Gao , Arman Avesta , Sanjay Aneja , Jay C. Wang , Lucian V. Del Priore , Smita Krishnaswamy

High-quality quadrilateral mesh generation is a fundamental challenge in computer graphics. Traditional optimization-based methods are often constrained by the topological quality of input meshes and suffer from severe efficiency…

Graphics · Computer Science 2026-03-12 Yuguang Chen , Xinhai Liu , Xiangyu Zhu , Yiling Zhu , Zhuo Chen , Dongyu Zhang , Chunchao Guo

High-dimensional data, characterized by many features, can be difficult to visualize effectively. Dimensionality reduction techniques, such as PCA, UMAP, and t-SNE, address this challenge by projecting the data into a lower-dimensional…

Topology reasoning is crucial for autonomous driving. Current methods primarily focus on instance-level learning for centerline detection, followed by a sequential module for topology reasoning that relies on simplified MLP layers.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Yifeng Bai , Zhirong Chen , Erkang Cheng , Haibin Ling

Whole heart segmentation (WHS) supports cardiovascular disease (CVD) diagnosis, disease monitoring, treatment planning, and prognosis. Deep learning has become the most widely used method for WHS applications in recent years. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-21 Chenyu Zhang , Wenxue Guan , Xiaodan Xing , Guang Yang