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Multi-period stock-keeping unit (SKU) allocation in supply chains is a combinatorial optimization problem that is both NP-hard and operationally critical, requiring simultaneous attention to profitability, feasibility, and diversity.…

For various optimization problems, the classical time to solution is super-polynomial and intractable to solve with classical bit-based computing hardware to date. Digital and quantum annealers have the potential to identify near-optimal…

Quantum Physics · Physics 2025-11-05 Milind Upadhyay , Mark Nicholas Jones

The field of Quantum Computing has gathered significant popularity in recent years and a large number of papers have studied its effectiveness in tackling many tasks. We focus in particular on Quantum Annealing (QA), a meta-heuristic solver…

Quantum Physics · Physics 2026-03-03 Riccardo Pellini , Maurizio Ferrari Dacrema

Accurate prediction of mRNA secondary structure is critical for understanding gene expression, translation efficiency, and advancing mRNA-based therapeutics. However, the combinatorial complexity of possible foldings, especially in long…

Quantum information processing is likely to have far-reaching impact in the field of artificial intelligence. While the race to build an error-corrected quantum computer is ongoing, noisy, intermediate-scale quantum (NISQ) devices provide…

We introduce VeloxQ, a fast solver for Quadratic Unconstrained Binary Optimization (QUBO) problems, which are central to many real-world optimization tasks. Unlike approaches that depend on emerging quantum hardware, VeloxQ can be deployed…

Quantum Physics · Physics 2026-05-05 J. Pawłowski , J. Tuziemski , P. Tarasiuk , H. Louzada , R. Adamski , K. Hendzel , Ł. Pawela , B. Gardas

In this paper, we develop a way to encode several NP-Complete problems in Abstract Argumentation to Quadratic Unconstrained Binary Optimization (QUBO) problems. In this form, a solution for a QUBO problem involves minimizing a quadratic…

Quantum Physics · Physics 2024-09-10 Marco Baioletti , Francesco Santini

RNAs self-interact through hydrogen-bond base-pairing between nucleotides and fold into specific, stable structures that substantially govern their biochemical behaviour. Experimental characterization of these structures remains difficult,…

Quantum Physics · Physics 2023-05-02 Tristan Zaborniak , Juan Giraldo , Hausi Müller , Hosna Jabbari , Ulrike Stege

Quantum computing is poised to transform the financial industry, yet its advantages over traditional methods have not been evidenced. As this technology rapidly evolves, benchmarking is essential to fairly evaluate and compare different…

Optimization and Control · Mathematics 2025-02-11 Ying Chen , Thorsten Koch , Hanqiu Peng , Hongrui Zhang

Quadratic Unconstrained Binary Optimization (QUBO) is a broad class of optimization problems with many practical applications. To solve its hard instances in an exact way, known classical algorithms require exponential time and several…

Quantum Physics · Physics 2021-01-21 Gian Giacomo Guerreschi

In recent years, there is a growing interest in using quantum computers for solving combinatorial optimization problems. In this work, we developed a generic, machine learning-based framework for mapping continuous-space inverse design…

I present a novel use of quantum annealing to solve the Set Splitting Problem using (QUBO) problem formulation. The contribution of the work is in formulating penalty functions that ensure the ground state of the QUBO Hamiltonian…

Quantum Physics · Physics 2025-08-11 Sean Borneman

AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

We propose a practical, physics-inspired benchmarking suite to challenge both quantum and classical computers by mapping real-time quantum dynamics to a common optimization format. Using a parallel-in-time encoding, we convert the real-time…

Quantum Physics · Physics 2026-04-23 Philipp Hanussek , Jakub Pawłowski , Zakaria Mzaouali , Bartłomiej Gardas

In urban transport systems, time-varying demand and network conditions cause the importance of infrastructure elements to evolve, requiring the identification of period-specific critical links to support systemlevel risk and resilience…

Optimization and Control · Mathematics 2026-04-06 Junxiang Xu , Chence Niu , Tingting Zhang , Divya Jayakumar Nair , Vinayak Dixit

With the applications of quantum computing becoming more and more widespread, finding ways that allow end users without experience in the field to apply quantum computers to solve their individual problems is becoming a crucial task.…

Quantum Physics · Physics 2024-04-18 Damian Rovara , Nils Quetschlich , Robert Wille

Quantum computing is emerging as a new computing resource that could be superior to conventional computing for certain classes of optimization problems. However, in principle, most existing approaches to quantum optimization are intended to…

Optimization and Control · Mathematics 2022-01-21 Chin-Yao Chang , Eric Jones , Yiyun Yao , Peter Graf , Rishabh Jain

The major advances in quantum computing over the last few decades have sparked great interest in applying it to solve the most challenging computational problems in a wide variety of areas. One of the most pronounced domains here are…

Quantum Physics · Physics 2024-04-11 Andreas Sturm , Bharadwaj Mummaneni , Leon Rullkötter

Binary neural networks (BNNs) are increasingly deployed in edge computing applications due to their low hardware complexity and high energy efficiency. However, verifying the robustness of BNNs against input perturbations, including…

Emerging Technologies · Computer Science 2026-02-17 Rahul Singh , Seyran Saeedi , Zheng Zhang

The vehicle routing problem with time windows (VRPTW) is a common optimization problem faced within the logistics industry. In this work, we explore the use of a previously-introduced qubit encoding scheme to reduce the number of binary…

Quantum Physics · Physics 2023-09-20 Ioannis D. Leonidas , Alexander Dukakis , Benjamin Tan , Dimitris G. Angelakis