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Background: Cirrhosis is a progressive liver disease with high mortality and frequent complications, notably acute kidney injury (AKI), which occurs in up to 50% of hospitalized patients and worsens outcomes. AKI stems from complex…

Machine Learning · Computer Science 2025-08-15 Li Sun , Shuheng Chen , Junyi Fan , Yong Si , Minoo Ahmadi , Elham Pishgar , Kamiar Alaei , Maryam Pishgar

Clinical decisions are high-stakes and require explicit justification, making model interpretability essential for auditing deep clinical models prior to deployment. As the ecosystem of model architectures and explainability methods…

Machine Learning · Computer Science 2026-03-27 Yongda Fan , John Wu , Andrea Fitzpatrick , Naveen Baskaran , Jimeng Sun , Adam Cross

Social media platforms provide valuable insights into mental health trends by capturing user-generated discussions on conditions such as depression, anxiety, and suicidal ideation. Machine learning (ML) and deep learning (DL) models have…

Computation and Language · Computer Science 2025-04-28 Zhanyi Ding , Zhongyan Wang , Yeyubei Zhang , Yuchen Cao , Yunchong Liu , Xiaorui Shen , Yexin Tian , Jianglai Dai

Widespread adoption of AI for medical decision making is still hindered due to ethical and safety-related concerns. For AI-based decision support systems in healthcare settings it is paramount to be reliable and trustworthy. Common deep…

Machine Learning · Computer Science 2024-01-26 Adrian Lindenmeyer , Malte Blattmann , Stefan Franke , Thomas Neumuth , Daniel Schneider

The analysis of electrocardiogram (ECG) signals can be time consuming as it is performed manually by cardiologists. Therefore, automation through machine learning (ML) classification is being increasingly proposed which would allow ML…

Machine Learning · Computer Science 2022-05-10 Shourya Verma

Clinical machine learning faces a critical dilemma in high-stakes medical applications: algorithms achieving optimal diagnostic performance typically sacrifice the interpretability essential for physician decision-making, while…

Machine Learning · Computer Science 2025-09-23 Xiuqi Ge , Zhibo Yao , Yaosong Du

This paper presents a systematic literature review (SLR) on the explainability and interpretability of machine learning (ML) models within the context of predictive process mining, using the PRISMA framework. Given the rapid advancement of…

Machine Learning · Computer Science 2024-01-01 Nijat Mehdiyev , Maxim Majlatow , Peter Fettke

Addressing heart failure (HF) as a prevalent global health concern poses difficulties in implementing innovative approaches for enhanced patient care. Predicting mortality rates in HF patients, in particular, is difficult yet critical,…

Early detection of breast cancer is a powerful tool towards decreasing its socioeconomic burden. Although, artificial intelligence (AI) methods have shown remarkable results towards this goal, their "black box" nature hinders their wide…

Machine Learning · Computer Science 2022-02-07 Panagiota Karatza , Kalliopi V. Dalakleidi , Maria Athanasiou , Konstantina S. Nikita

Recent years have seen particular interest in using electronic medical records (EMRs) for secondary purposes to enhance the quality and safety of healthcare delivery. EMRs tend to contain large amounts of valuable clinical notes. Learning…

Computation and Language · Computer Science 2022-07-25 Hoda Memarzadeh , Nasser Ghadiri , Maryam Lotfi Shahreza

Detection of occult hemorrhage (i.e., internal bleeding) in patients in intensive care units (ICUs) can pose significant challenges for critical care workers. Because blood loss may not always be clinically apparent, clinicians rely on…

Electronic health records (EHR) are characterized as non-stationary, heterogeneous, noisy, and sparse data; therefore, it is challenging to learn the regularities or patterns inherent within them. In particular, sparseness caused mostly by…

Machine Learning · Computer Science 2020-03-03 Eunji Jun , Ahmad Wisnu Mulyadi , Jaehun Choi , Heung-Il Suk

Aplastic anemia is a rare, life-threatening hematologic disorder characterized by pancytopenia and bone marrow failure. ICU admission in these patients often signals critical complications or disease progression, making early risk…

Machine Learning · Computer Science 2025-05-27 Junyi Fan , Shuheng Chen , Li Sun , Yong Si , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Machine learning models have had discernible achievements in a myriad of applications. However, most of these models are black-boxes, and it is obscure how the decisions are made by them. This makes the models unreliable and untrustworthy.…

Machine Learning · Computer Science 2020-03-23 Raha Moraffah , Mansooreh Karami , Ruocheng Guo , Adrienne Raglin , Huan Liu

Interpretability remains a key challenge for deploying large language models (LLMs) in clinical settings such as Alzheimer's disease progression diagnosis, where early and trustworthy predictions are essential. Existing attribution methods…

Causal inference and model interpretability are gaining increasing attention, particularly in the biomedical domain. Despite recent advance, decorrelating features in nonlinear environments with human-interpretable representations remains…

Machine Learning · Computer Science 2024-11-12 Junda Wang , Weijian Li , Han Wang , Hanjia Lyu , Caroline P. Thirukumaran , Addisu Mesfin , Hong Yu , Jiebo Luo

The local and global interpretability of various ML models has been studied extensively in recent years. However, despite significant progress in the field, many known results remain informal or lack sufficient mathematical rigor. We…

Machine Learning · Computer Science 2024-06-10 Shahaf Bassan , Guy Amir , Guy Katz

With an increasing focus on precision medicine in medical research, numerous studies have been conducted in recent years to clarify the relationship between treatment effects and patient characteristics. The treatment effects for patients…

Methodology · Statistics 2023-09-22 Ke Wan , Kensuke Tanioka , Toshio Shimokawa

As the second wave in India mitigates, COVID-19 has now infected about 29 million patients countrywide, leading to more than 350 thousand people dead. As the infections surged, the strain on the medical infrastructure in the country became…

Machine Learning · Computer Science 2021-10-26 Samarth Bhatia , Yukti Makhija , Sneha Jayaswal , Shalendra Singh , Ishaan Gupta

The rapid progress in clinical data management systems and artificial intelligence approaches enable the era of personalized medicine. Intensive care units (ICUs) are the ideal clinical research environment for such development because they…

Computation and Language · Computer Science 2022-09-28 Thanh-Dung Le , Rita Noumeir , Jerome Rambaud , Guillaume Sans , Philippe Jouvet
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