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In image-guided neurosurgery, current commercial systems usually provide only rigid registration, partly because it is harder to predict, validate and understand non-rigid registration error. For instance, when surgeons see a discrepancy in…

Computer Vision and Pattern Recognition · Computer Science 2020-03-24 Jie Luo , Sarah Frisken , Duo Wang , Alexandra Golby , Masashi Sugiyama , William M. Wells

Scientific software relies on high-precision computation, yet finite floating-point representations can introduce precision errors that propagate in safety-critical domains. Despite the growing use of large language models (LLMs) in…

Software Engineering · Computer Science 2026-04-10 Tien Nguyen , Kirshanthan Sundararajah , Muhammad Ali Gulzar

Estimating the uncertainty in (probabilistic) image registration enables, e.g., surgeons to assess the operative risk based on the trustworthiness of the registered image data. If surgeons receive inaccurately calculated registration…

Computer Vision and Pattern Recognition · Computer Science 2020-04-27 Jie Luo , Alireza Sedghi , Karteek Popuri , Dana Cobzas , Miaomiao Zhang , Frank Preiswerk , Matthew Toews , Alexandra Golby , Masashi Sugiyama , William M. Wells , Sarah Frisken

Over recent years, deep learning based image registration has achieved impressive accuracy in many domains, including medical imaging and, specifically, human neuroimaging with magnetic resonance imaging (MRI). However, the uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Xiaoling Hu , Karthik Gopinath , Peirong Liu , Malte Hoffmann , Koen Van Leemput , Oula Puonti , Juan Eugenio Iglesias

Accurate image registration is essential in many medical imaging applications, yet most deep registration networks provide little indication of when or where their predictions are unreliable. Existing uncertainty estimation approaches, such…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Lin Tian , Xiaoling Hu , Juan Eugenio Iglesias

Ensuring the long-term reproducibility of data analyses requires results stability tests to verify that analysis results remain within acceptable variation bounds despite inevitable software updates and hardware evolutions. This paper…

Machine learning (ML) applications have become an integral part of our lives. ML applications extensively use floating-point computation and involve very large/small numbers; thus, maintaining the numerical stability of such complex…

Software Engineering · Computer Science 2025-04-24 Shaila Sharmin , Anwar Hossain Zahid , Subhankar Bhattacharjee , Chiamaka Igwilo , Miryung Kim , Wei Le

When deploying deep neural networks on robots or other physical systems, the learned model should reliably quantify predictive uncertainty. A reliable uncertainty allows downstream modules to reason about the safety of its actions. In this…

Machine Learning · Computer Science 2024-10-30 Simon Kristoffersson Lind , Ziliang Xiong , Per-Erik Forssén , Volker Krüger

We describe a diffeomorphic registration algorithm that allows groups of images to be accurately aligned to a common space, which we intend to incorporate into the SPM software. The idea is to perform inference in a probabilistic graphical…

Computer Vision and Pattern Recognition · Computer Science 2021-05-10 Mikael Brudfors , Yaël Balbastre , Guillaume Flandin , Parashkev Nachev , John Ashburner

Acquisition-to-acquisition signal intensity variations (non-standardness) are inherent in MR images. Standardization is a post processing method for correcting inter-subject intensity variations through transforming all images from the…

Computer Vision and Pattern Recognition · Computer Science 2015-05-18 Ulas Bagci , Jayaram K. Udupa , Li Bai

The detection of malware is a critical task for the protection of computing environments. This task often requires extremely low false positive rates (FPR) of 0.01% or even lower, for which modern machine learning has no readily available…

Machine Learning · Computer Science 2021-09-07 Andre T. Nguyen , Edward Raff , Charles Nicholas , James Holt

This paper investigates the numerical uncertainty of Convolutional Neural Networks (CNNs) inference for structural brain MRI analysis. It applies Random Rounding -- a stochastic arithmetic technique -- to CNN models employed in non-linear…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Inés Gonzalez Pepe , Vinuyan Sivakolunthu , Hae Lang Park , Yohan Chatelain , Tristan Glatard

Linear programming is widely used for decision-making in science, engineering, and operations research, yet in many modern applications the coefficients entering the constraints and objective are not known exactly and must be learned from…

Other Statistics · Statistics 2026-03-09 Debashis Chatterjee

Recent works in medical image registration have proposed the use of Implicit Neural Representations, demonstrating performance that rivals state-of-the-art learning-based methods. However, these implicit representations need to be optimized…

Image and Video Processing · Electrical Eng. & Systems 2023-10-04 Louis D. van Harten , Jaap Stoker , Ivana Išgum

Clinical dataset labels are rarely certain as annotators disagree and confidence is not uniform across cases. Typical aggregation procedures, such as majority voting, obscure this variability. In simple experiments on medical imaging…

Pathology foundation models (PFMs) have become central to computational pathology, aiming to offer general encoders for feature extraction from whole-slide images (WSIs). Despite strong benchmark performance, PFM robustness to real-world…

Image and Video Processing · Electrical Eng. & Systems 2026-01-08 Erik Thiringer , Fredrik K. Gustafsson , Kajsa Ledesma Eriksson , Mattias Rantalainen

We present USLR, a computational framework for longitudinal registration of brain MRI scans to estimate nonlinear image trajectories that are smooth across time, unbiased to any timepoint, and robust to imaging artefacts. It operates on the…

Image and Video Processing · Electrical Eng. & Systems 2023-11-15 Adrià Casamitjana , Roser Sala-Llonch , Karim Lekadir , Juan Eugenio Iglesias

Pre-trained language models (PLMs) have gained increasing popularity due to their compelling prediction performance in diverse natural language processing (NLP) tasks. When formulating a PLM-based prediction pipeline for NLP tasks, it is…

Computation and Language · Computer Science 2022-10-17 Yuxin Xiao , Paul Pu Liang , Umang Bhatt , Willie Neiswanger , Ruslan Salakhutdinov , Louis-Philippe Morency

Machine learning (ML) models are increasingly being used in metrology applications. However, for ML models to be credible in a metrology context they should be accompanied by principled uncertainty quantification. This paper addresses the…

Machine Learning · Computer Science 2024-05-09 Andrew Thompson

This paper studies uncertainty set estimation for unknown linear systems. Uncertainty sets are crucial for the quality of robust control since they directly influence the conservativeness of the control design. Departing from the confidence…

Optimization and Control · Mathematics 2024-06-11 Yingying Li , Jing Yu , Lauren Conger , Taylan Kargin , Adam Wierman
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