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To discover new drugs is to seek and to prove causality. As an emerging approach leveraging human knowledge and creativity, data, and machine intelligence, causal inference holds the promise of reducing cognitive bias and improving decision…

Quantitative Methods · Quantitative Biology 2025-04-09 Tom Michoel , Jitao David Zhang

Time-varying causal models provide a powerful framework for studying dynamic scientific systems, yet most existing approaches assume that the underlying causal network is known a priori - an assumption rarely satisfied in real-world domains…

Machine Learning · Computer Science 2026-05-28 Dmitry Zaytsev , Valentina Kuskova , Michael Coppedge

The safe deployment of large language models (LLMs) in high-stakes fields like biomedicine, requires them to be able to reason about cause and effect. We investigate this ability by testing 13 open-source LLMs on a fundamental task:…

Computation and Language · Computer Science 2026-03-13 Sydney Anuyah , Sneha Shajee-Mohan , Ankit-Singh Chauhan , Sunandan Chakraborty

Causal structure discovery from observations can be improved by integrating background knowledge provided by an expert to reduce the hypothesis space. Recently, Large Language Models (LLMs) have begun to be considered as sources of prior…

Machine Learning · Computer Science 2024-05-24 Victor-Alexandru Darvariu , Stephen Hailes , Mirco Musolesi

Causal learning is the cognitive process of developing the capability of making causal inferences based on available information, often guided by normative principles. This process is prone to errors and biases, such as the illusion of…

The study of causal structure in complex systems has gained increasing attention, with many recent studies exploring causal networks that capture cause-effect relationships across diverse fields. Despite increasing empirical evidence…

Physics and Society · Physics 2025-02-26 Jiazhen Liu , Kunal Tamang , Dashun Wang , Chaoming Song

Climate models are essential to understand and project climate change, yet long-standing biases and uncertainties in their projections remain. This is largely associated with the representation of subgrid-scale processes, particularly…

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable…

Machine Learning · Computer Science 2023-01-20 Pulakesh Upadhyaya , Kai Zhang , Can Li , Xiaoqian Jiang , Yejin Kim

Causal induction, i.e., identifying unobservable mechanisms that lead to the observable relations among variables, has played a pivotal role in modern scientific discovery, especially in scenarios with only sparse and limited data. Humans,…

Computer Vision and Pattern Recognition · Computer Science 2021-03-29 Chi Zhang , Baoxiong Jia , Mark Edmonds , Song-Chun Zhu , Yixin Zhu

Computational analysis of time-course data with an underlying causal structure is needed in a variety of domains, including neural spike trains, stock price movements, and gene expression levels. However, it can be challenging to determine…

Artificial Intelligence · Computer Science 2012-05-14 Samantha Kleinberg , Bud Mishra

Causal modeling provides us with powerful counterfactual reasoning and interventional mechanism to generate predictions and reason under various what-if scenarios. However, causal discovery using observation data remains a nontrivial task…

Machine Learning · Computer Science 2023-01-06 Jawad Chowdhury , Rezaur Rashid , Gabriel Terejanu

Contextual causal reasoning is a critical yet challenging capability for Large Language Models (LLMs). Existing benchmarks, however, often evaluate this skill in fragmented settings, failing to ensure context consistency or cover the full…

Computation and Language · Computer Science 2026-04-17 Pengfeng Li , Chen Huang , Chaoqun Hao , Hongyao Chen , Xiao-Yong Wei , Wenqiang Lei , See-Kiong Ng

In this paper we present a comprehensive view of prominent causal discovery algorithms, categorized into two main categories (1) assuming acyclic and no latent variables, and (2) allowing both cycles and latent variables, along with…

Artificial Intelligence · Computer Science 2017-09-13 Karamjit Singh , Garima Gupta , Vartika Tewari , Gautam Shroff

Implicit Sentiment Analysis (ISA) aims to infer sentiment that is implied rather than explicitly stated, requiring models to perform deeper reasoning over subtle contextual cues. While recent prompting-based methods using Large Language…

Computation and Language · Computer Science 2025-07-02 Jing Ren , Wenhao Zhou , Bowen Li , Mujie Liu , Nguyen Linh Dan Le , Jiade Cen , Liping Chen , Ziqi Xu , Xiwei Xu , Xiaodong Li

Automated systems built on artificial intelligence (AI) are increasingly deployed across high-stakes domains, raising critical concerns about fairness and the perpetuation of demographic disparities that exist in the world. In this context,…

Artificial Intelligence · Computer Science 2026-05-19 Drago Plecko

Large language models (LLMs) have recently shown remarkable performance in language tasks and beyond. However, due to their limited inherent causal reasoning ability, LLMs still face challenges in handling tasks that require robust causal…

Computation and Language · Computer Science 2025-03-13 Xin Li , Zhuo Cai , Shoujin Wang , Kun Yu , Fang Chen

Causal discovery through experimentation and intervention is fundamental to robust problem solving. It requires not just updating beliefs within a fixed framework but revising the hypothesis space itself, a capacity current AI agents lack…

Artificial Intelligence · Computer Science 2026-04-23 John Alderete , Sebastian Benthal , Connie Xu , John Xing

Yield and quality improvement is of paramount importance to any manufacturing company. One of the ways of improving yield is through discovery of the root causal factors affecting yield. We propose the use of data-driven interpretable…

Machine Learning · Computer Science 2016-06-15 Katerina Marazopoulou , Rumi Ghosh , Prasanth Lade , David Jensen

In this study, we introduced a new benchmark consisting of a curated dataset and a defined evaluation process to assess the compositional reasoning capabilities of large language models within the chemistry domain. We designed and validated…

Computation and Language · Computer Science 2025-08-07 Mohammad Khodadad , Ali Shiraee Kasmaee , Mahdi Astaraki , Nicholas Sherck , Hamidreza Mahyar , Soheila Samiee

This paper describes the development of a causal diagnosis approach for troubleshooting an industrial environment on the basis of the technical language expressed in Return on Experience records. The proposed method leverages the vectorized…

Artificial Intelligence · Computer Science 2024-07-31 Alexandre Trilla , Ossee Yiboe , Nenad Mijatovic , Jordi Vitrià
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