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Related papers: SmilesT5: Domain-specific pretraining for molecula…

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Molecular deep learning models have achieved remarkable success in property prediction, but they often require large amounts of labeled data. The challenge is that, in real-world applications, labels are extremely scarce, as obtaining them…

Machine Learning · Computer Science 2025-07-21 Kevin Tirta Wijaya , Minghao Guo , Michael Sun , Hans-Peter Seidel , Wojciech Matusik , Vahid Babaei

With the emergence of Transformer architectures and their powerful understanding of textual data, a new horizon has opened up to predict the molecular properties based on text description. While SMILES are the most common form of…

Chemical Physics · Physics 2023-10-11 Suryanarayanan Balaji , Rishikesh Magar , Yayati Jadhav , Amir Barati Farimani

Simile interpretation is a crucial task in natural language processing. Nowadays, pre-trained language models (PLMs) have achieved state-of-the-art performance on many tasks. However, it remains under-explored whether PLMs can interpret…

Computation and Language · Computer Science 2022-03-17 Qianyu He , Sijie Cheng , Zhixu Li , Rui Xie , Yanghua Xiao

Deep learning (DL) techniques are gaining more and more attention in the software engineering community. They have been used to support several code-related tasks, such as automatic bug fixing and code comments generation. Recent studies in…

Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Genomics · Quantitative Biology 2025-06-24 Sohan Mupparapu , Parameswari Krishnamurthy , Ratish Puduppully

Large pretrained language models (PLMs) are often domain- or task-adapted via fine-tuning or prompting. Finetuning requires modifying all of the parameters and having enough data to avoid overfitting while prompting requires no training and…

Computation and Language · Computer Science 2022-07-11 Zejiang Hou , Julian Salazar , George Polovets

Large, pre-trained representation models trained using self-supervised learning have gained popularity in various fields of machine learning because they are able to extract high-quality salient features from input data. As such, they have…

Audio and Speech Processing · Electrical Eng. & Systems 2023-06-16 Hejung Yang , Hong-Goo Kang

Learning word representations has recently seen much success in computational linguistics. However, assuming sequences of word tokens as input to linguistic analysis is often unjustified. For many languages word segmentation is a…

Computation and Language · Computer Science 2013-09-19 Grzegorz Chrupała

Speech representations learned from Self-supervised learning (SSL) models can benefit various speech processing tasks. However, utilizing SSL representations usually requires fine-tuning the pre-trained models or designing task-specific…

Audio and Speech Processing · Electrical Eng. & Systems 2022-07-12 Kai-Wei Chang , Wei-Cheng Tseng , Shang-Wen Li , Hung-yi Lee

Domain adaptation for large neural language models (NLMs) is coupled with massive amounts of unstructured data in the pretraining phase. In this study, however, we show that pretrained NLMs learn in-domain information more effectively and…

Computation and Language · Computer Science 2022-08-30 Shahriar Golchin , Mihai Surdeanu , Nazgol Tavabi , Ata Kiapour

Generative pre-trained Transformer (GPT) has demonstrates its great success in natural language processing and related techniques have been adapted into molecular modeling. Considering that text is the most important record for scientific…

Computation and Language · Computer Science 2023-05-29 Zequn Liu , Wei Zhang , Yingce Xia , Lijun Wu , Shufang Xie , Tao Qin , Ming Zhang , Tie-Yan Liu

Masked language modeling has become a standard pretraining objective for training encoder-based language models. In this approach, certain tokens in the input are masked, and the model learns to predict them using the surrounding context.…

Artificial Intelligence · Computer Science 2026-05-28 Gokul Srinivasagan , Kai Hartung , Munir Georges

Knowledge of mixtures' phase equilibria is crucial in nature and technical chemistry. Phase equilibria calculations of mixtures require activity coefficients. However, experimental data on activity coefficients is often limited due to high…

Chemical Physics · Physics 2023-09-22 Benedikt Winter , Clemens Winter , Johannes Schilling , André Bardow

Transformer-based large language models have remarkable potential to accelerate design optimization for applications such as drug development and materials discovery. Self-supervised pretraining of transformer models requires large-scale…

Machine Learning · Computer Science 2023-10-27 Pei Zhang , Logan Kearney , Debsindhu Bhowmik , Zachary Fox , Amit K. Naskar , John Gounley

Existing curriculum learning approaches to Neural Machine Translation (NMT) require sampling sufficient amounts of "easy" samples from training data at the early training stage. This is not always achievable for low-resource languages where…

Computation and Language · Computer Science 2021-03-23 Chen Liang , Haoming Jiang , Xiaodong Liu , Pengcheng He , Weizhu Chen , Jianfeng Gao , Tuo Zhao

Finetuning is a common practice widespread across different communities to adapt pretrained models to particular tasks. Text classification is one of these tasks for which many pretrained models are available. On the other hand, ensembles…

Computation and Language · Computer Science 2024-10-29 Sebastian Pineda Arango , Maciej Janowski , Lennart Purucker , Arber Zela , Frank Hutter , Josif Grabocka

Language modeling studies the probability distributions over strings of texts. It is one of the most fundamental tasks in natural language processing (NLP). It has been widely used in text generation, speech recognition, machine…

Computation and Language · Computer Science 2024-07-18 Chengwei Wei , Yun-Cheng Wang , Bin Wang , C. -C. Jay Kuo

Language models for molecular design have scaled to hundreds of millions of parameters, yet how they learn chemical grammar is poorly understood. We train SMolLM, a 53K-parameter weight-shared transformer, to generate novel SMILES with 95%…

Machine Learning · Computer Science 2026-05-29 Akhil Jindal , Harang Ju

Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

Masked language modeling (MLM) is one of the key sub-tasks in vision-language pretraining. In the cross-modal setting, tokens in the sentence are masked at random, and the model predicts the masked tokens given the image and the text. In…

Computation and Language · Computer Science 2021-09-07 Yonatan Bitton , Gabriel Stanovsky , Michael Elhadad , Roy Schwartz