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Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Genomics · Quantitative Biology 2025-06-24 Sohan Mupparapu , Parameswari Krishnamurthy , Ratish Puduppully

The prevailing paradigm in large language model (LLM) development is to pretrain a base model, then perform further training to improve performance and model behavior. However, hyperparameter optimization and scaling laws have been studied…

Machine Learning · Computer Science 2026-02-12 Tessa Han , Sebastian Bordt , Hanlin Zhang , Sham Kakade

Pretraining monolingual language models have been proven to be vital for performance in Arabic Natural Language Processing (NLP) tasks. In this paper, we conduct a comprehensive study on the role of data in Arabic Pretrained Language Models…

Computation and Language · Computer Science 2024-01-17 Abbas Ghaddar , Philippe Langlais , Mehdi Rezagholizadeh , Boxing Chen

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

Scaling laws provide important insights that can guide the design of large language models (LLMs). Existing work has primarily focused on studying scaling laws for pretraining (upstream) loss. However, in transfer learning settings, in…

Computation and Language · Computer Science 2026-01-30 Berivan Isik , Natalia Ponomareva , Hussein Hazimeh , Dimitris Paparas , Sergei Vassilvitskii , Sanmi Koyejo

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Machine Learning · Computer Science 2022-06-29 Erik Nijkamp , Jeffrey Ruffolo , Eli N. Weinstein , Nikhil Naik , Ali Madani

Pre-trained language models (PLMs) may fail in giving reliable estimates of their predictive uncertainty. We take a close look into this problem, aiming to answer two questions: (1) Do PLMs learn to become calibrated in the training…

Computation and Language · Computer Science 2023-05-09 Yangyi Chen , Lifan Yuan , Ganqu Cui , Zhiyuan Liu , Heng Ji

Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Recently, due to their capacity and representation ability, pre-trained protein language models have achieved state-of-the-art performance in…

Biomolecules · Quantitative Biology 2024-02-06 Ziyi Zhou , Liang Zhang , Yuanxi Yu , Mingchen Li , Liang Hong , Pan Tan

Scaling laws for language models have often focused on finding the optimal model size and token count for training from scratch. However, achieving this optimal balance requires significant compute resources due to the extensive data…

Computation and Language · Computer Science 2025-04-01 Roseval Malaquias Junior , Ramon Pires , Thales Sales Almeida , Kenzo Sakiyama , Roseli A. F. Romero , Rodrigo Nogueira

In the domain of data science, the predictive tasks of classification, regression, and imputation of missing values are commonly encountered challenges associated with tabular data. This research endeavors to apply Large Language Models…

Machine Learning · Computer Science 2026-04-23 Yazheng Yang , Yuqi Wang , Yaxuan Li , Sankalok Sen , Lei Li , Lin Qiu , Qi Liu

Large Language Models (LLMs) represent a promising frontier for recommender systems, yet their development has been impeded by the absence of predictable scaling laws, which are crucial for guiding research and optimizing resource…

Information Retrieval · Computer Science 2026-02-16 Benyu Zhang , Qiang Zhang , Jianpeng Cheng , Hong-You Chen , Qifei Wang , Wei Sun , Shen Li , Jia Li , Jiahao Wu , Xiangjun Fan , Hong Yan

The rapid advancement of Large Language Models (LLMs), particularly those trained on multilingual corpora, has intensified the need for a deeper understanding of their performance across a diverse range of languages and model sizes. Our…

Computation and Language · Computer Science 2025-01-13 Rhitabrat Pokharel , Sina Bagheri Nezhad , Ameeta Agrawal , Suresh Singh

Domain reweighting is an emerging research area aimed at adjusting the relative weights of different data sources to improve the effectiveness and efficiency of LLM pre-training. We show that data mixtures that perform well at smaller…

Machine Learning · Computer Science 2025-10-03 Feiyang Kang , Yifan Sun , Bingbing Wen , Si Chen , Dawn Song , Rafid Mahmood , Ruoxi Jia

Large-scale Protein Language Models (PLMs) have improved performance in protein prediction tasks, ranging from 3D structure prediction to various function predictions. In particular, AlphaFold, a ground-breaking AI system, could potentially…

Quantitative Methods · Quantitative Biology 2022-10-18 Mingyang Hu , Fajie Yuan , Kevin K. Yang , Fusong Ju , Jin Su , Hui Wang , Fei Yang , Qiuyang Ding

The prediction of protein structures from sequences is an important task for function prediction, drug design, and related biological processes understanding. Recent advances have proved the power of language models (LMs) in processing the…

Quantitative Methods · Quantitative Biology 2022-12-01 Bozhen Hu , Jun Xia , Jiangbin Zheng , Cheng Tan , Yufei Huang , Yongjie Xu , Stan Z. Li

Neural scaling laws have driven significant advancements in machine learning, particularly in domains like language modeling and computer vision. However, the exploration of neural scaling laws within robotics has remained relatively…

Robotics · Computer Science 2025-01-28 Sebastian Sartor , Neil Thompson

Protein Language Models (PLMs) have emerged as performant and scalable tools for predicting the functional impact and clinical significance of protein-coding variants, but they still lag experimental accuracy. Here, we present a novel…

Fueled by their remarkable ability to tackle diverse tasks across multiple domains, large language models (LLMs) have grown at an unprecedented rate, with some recent models containing trillions of parameters. This growth is accompanied by…

Machine Learning · Computer Science 2025-05-30 Athanasios Glentis , Jiaxiang Li , Qiulin Shang , Andi Han , Ioannis Tsaknakis , Quan Wei , Mingyi Hong

Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the…

Quantitative Methods · Quantitative Biology 2024-08-14 Kamyar Zeinalipour , Neda Jamshidi , Monica Bianchini , Marco Maggini , Marco Gori

Large language models (LLMs) have demonstrated significant success in natural language processing (NLP) tasks and have shown promising results in other domains such as protein sequence generation. However, there remain salient differences…

Biomolecules · Quantitative Biology 2024-11-12 Aayush Shah , Shankar Jayaratnam