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This work studies lung tumor growth prediction from sparse and irregular longitudinal computed tomography (CT) observations with measurement variability. A Bayesian physics-informed neural network is developed by combining Gompertz growth…

Machine Learning · Computer Science 2026-05-14 Lingfei Kong , Haoran Ma

Many real-world complex systems are well represented as multilayer networks; predicting interactions in those systems is one of the most pressing problems in predictive network science. To address this challenge, we introduce two stochastic…

Physics and Society · Physics 2019-04-03 Marc Tarres-Deulofeu , Antonia Godoy-Lorite , Roger Guimera , Marta Sales-Pardo

Cancer is a significant health issue globally and it is well known that cancer risk varies geographically. However in many countries there are no small area level data on cancer risk factors with high resolution and complete reach, which…

Applications · Statistics 2024-03-04 James Hogg , Jessica Cameron , Susanna Cramb , Peter Baade , Kerrie Mengersen

Breast cancer is a serious disease that inflicts millions of people each year, and the number of cases is increasing. Early detection is the best way to reduce the impact of the disease. Researchers have developed many techniques to detect…

Artificial Intelligence · Computer Science 2023-11-23 Mosab S. M. Farea , zhe chen

Joint modeling technique is a recent advancement in effectively analyzing the longitudinal history of patients with the occurrence of an event of interest attached to it. This procedure is successfully implemented in biomarker studies to…

Methodology · Statistics 2021-01-08 Gajendra K. Vishwakarma , Atanu Bhattacharjee , Souvik Banerjee

Spatio-temporal prediction of levels of an environmental exposure is an important problem in environmental epidemiology. Our work is motivated by multiple studies on the spatio-temporal distribution of mobile source, or traffic related,…

Applications · Statistics 2014-11-14 Nikolay Bliznyuk , Christopher J. Paciorek , Joel Schwartz , Brent Coull

Understanding cancer cell differentiation is essential for advancing its detection, diagnosis, and treatment. Mathematical models significantly contribute to this by providing a theoretical framework to understand the complex interactions…

Tissues and Organs · Quantitative Biology 2025-08-18 Marcela V. Reale , Gustavo Paccosi , David H. Margarit , Lilia Romanelli

This paper considers small-area estimation with lung cancer mortality data, and discusses the choice of upper-level model for the variation over areas. Inference about the random effects for the areas may depend strongly on the choice of…

Applications · Statistics 2009-05-25 Murray Aitkin , Charles C. Liu , Tom Chadwick

The recent development of imaging and sequencing technologies enables systematic advances in the clinical study of lung cancer. Meanwhile, the human mind is limited in effectively handling and fully utilizing the accumulation of such…

Machine Learning · Computer Science 2022-03-29 Yawei Li , Xin Wu , Ping Yang , Guoqian Jiang , Yuan Luo

As the COVID-19 pandemic continues to ravage the world, it is of critical significance to provide a timely risk prediction of the COVID-19 in multi-level. To implement it and evaluate the public health policies, we develop a framework with…

Physics and Society · Physics 2020-12-02 Lingxiao Wang , Tian Xu , Till Hannes Stoecker , Horst Stoecker , Yin Jiang , Kai Zhou

The potential benefits of applying machine learning methods to -omics data are becoming increasingly apparent, especially in clinical settings. However, the unique characteristics of these data are not always well suited to machine learning…

In public health, it is critical for policymakers to assess the relationship between the disease prevalence and associated risk factors or clinical characteristics, facilitating effective resources allocation. However, for diseases like…

Multiplex immunofluorescence (mIF) imaging technology facilitates the study of the tumour microenvironment in cancer patients. Due to the capabilities of this emerging bioimaging technique, it is possible to statistically analyse, for…

Applications · Statistics 2023-07-07 Jonatan A. González , Julia Wrobel , Simon Vandekar , Paula Moraga

In this paper, we introduce a new spatial model that incorporates heteroscedastic variance depending on neighboring locations. The proposed process is regarded as the spatial equivalent to the temporal autoregressive conditional…

Statistics Theory · Mathematics 2020-10-20 Philipp Otto , Wolfgang Schmid , Robert Garthoff

Data from multiple prevalence surveys can provide information on common parameters of interest, which can therefore be estimated more precisely in a joint analysis than by separate analyses of the data from each survey. However, fitting a…

Applications · Statistics 2013-12-23 Emanuele Giorgi , Sanie S. S. Sesay , Dianne J. Terlouw , Peter J. Diggle

Effective learning from electronic health records (EHR) data for prediction of clinical outcomes is often challenging because of features recorded at irregular timesteps and loss to follow-up as well as competing events such as death or…

Machine Learning · Computer Science 2022-08-11 Intae Moon , Stefan Groha , Alexander Gusev

This paper focuses on the task of survival time analysis for lung cancer. Although much progress has been made in this problem in recent years, the performance of existing methods is still far from satisfactory. Traditional and some deep…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Yujiao Wu , Yaxiong Wang , Xiaoshui Huang , Fan Yang , Sai Ho Ling , Steven Weidong Su

The prevalence of multivariate space-time data collected from monitoring networks and satellites, or generated from numerical models, has brought much attention to multivariate spatio-temporal statistical models, where the covariance…

Methodology · Statistics 2023-03-14 Huang Huang , Ying Sun , Marc G. Genton

Gastric cancer and Colon adenocarcinoma represent widespread and challenging malignancies with high mortality rates and complex treatment landscapes. In response to the critical need for accurate prognosis in cancer patients, the medical…

Image and Video Processing · Electrical Eng. & Systems 2024-04-16 Xu Yan , Weimin Wang , MingXuan Xiao , Yufeng Li , Min Gao

Background: Accurate survival prediction in breast cancer is essential for patient stratification and personalized therapy. Integrating gene expression data with clinical factors may enhance prognostic performance and support precision…

Quantitative Methods · Quantitative Biology 2025-08-26 Robert Amevor , Emmanuel Kubuafor , Dennis Baidoo , Junaidu Salifu , Koshali Muthunama Gonnage , Onyedikachi Joshua Okeke