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Large language models demonstrate strong performance on mathematical reasoning benchmarks, yet remain surprisingly fragile to meaning-preserving surface perturbations. We systematically evaluate three open-weight LLMs, Mistral-7B,…

Computation and Language · Computer Science 2026-04-03 Shou-Tzu Han , Rodrigue Rizk , KC Santosh

Clinical diagnosis requires sequential evidence acquisition under uncertainty. However, most Large Language Model (LLM) based diagnostic systems assume fully observed patient information and therefore do not explicitly model how clinical…

Artificial Intelligence · Computer Science 2026-04-08 Xuyang Shen , Haoran Liu , Dongjin Song , Martin Renqiang Min

Large language models (LLMs) are increasingly utilized in clinical reasoning and risk assessment. However, their interpretive reliability in critical and indeterminate domains such as psychiatry remains unclear. Prior work has identified…

Machine Learning · Computer Science 2026-04-30 Shevya Panda , Shinjini Bose , Ananya Joshi

In recent years, Large language model-powered Automated Program Repair (LAPR) techniques have achieved state-of-the-art bug-fixing performance and have been pervasively applied and studied in both industry and academia. Nonetheless, LLMs…

Software Engineering · Computer Science 2025-03-11 Pengyu Xue , Linhao Wu , Zhen Yang , Zhongxing Yu , Zhi Jin , Ge Li , Yan Xiao , Shuo Liu , Xinyi Li , Hongyi Lin , Jingwen Wu

Deformable image registration plays an essential role in various medical image tasks. Existing deep learning-based deformable registration frameworks primarily utilize convolutional neural networks (CNNs) or Transformers to learn features…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Jiong Wu , Kuang Gong

Neuroimaging data, particularly from techniques like MRI or PET, offer rich but complex information about brain structure and activity. To manage this complexity, latent representation models - such as Autoencoders, Generative Adversarial…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 C. Vázquez-García , F. J. Martínez-Murcia , F. Segovia Román , Juan M. Górriz

A decade of rapid advances in artificial intelligence (AI) has opened new opportunities for clinical decision support systems (CDSS), with large language models (LLMs) demonstrating strong reasoning abilities on timely medical tasks.…

Computation and Language · Computer Science 2025-11-25 Heejoon Koo

Background. Large Language Models (LLMs) hold promise for improving genetic variant literature review in clinical testing. We assessed Generative Pretrained Transformer 4's (GPT-4) performance, nondeterminism, and drift to inform its…

Real-world decision-making, from tax compliance assessment to medical diagnosis, requires aggregating multiple noisy and potentially contradictory evidence sources. Existing approaches either lack explicit uncertainty quantification (neural…

Artificial Intelligence · Computer Science 2026-03-19 Aliyu Agboola Alege

Flow physics and more broadly physical phenomena governed by partial differential equations (PDEs), are inherently continuous, high-dimensional and often chaotic in nature. Traditionally, researchers have explored these rich spatiotemporal…

Large language models (LLMs) frequently achieve impressive scores on standardized benchmarks, yet accuracy alone offers a limited view of their capabilities. Evaluating open-source LLMs through leaderboards faces persistent issues like data…

Large language models (LLMs) are entering clinician workflows, yet evaluations rarely measure how clinician reasoning shapes model behavior during clinical interactions. We combined 61 New England Journal of Medicine Case Records with 92…

We present Latent Diffeomorphic Dynamic Mode Decomposition (LDDMD), a new data reduction approach for the analysis of non-linear systems that combines the interpretability of Dynamic Mode Decomposition (DMD) with the predictive power of…

Machine Learning · Computer Science 2025-08-04 Willem Diepeveen , Jon Schwenk , Andrea Bertozzi

Large Language Models (LLMs) are increasingly used in clinical settings, where sensitivity to linguistic uncertainty can influence diagnostic interpretation and decision-making. Yet little is known about where such epistemic cues are…

Computation and Language · Computer Science 2025-12-01 Srivarshinee Sridhar , Raghav Kaushik Ravi , Kripabandhu Ghosh

Large Language Models (LLMs) are increasingly deployed in high-stakes domains such as clinical decision support and medical documentation. However, the robustness of these models against subtle linguistic variations, specifically…

Computation and Language · Computer Science 2026-05-19 Jen-tse Huang , Didi Zhou , Faith Kamau , Amy Oh , Anne R. Links , Mark Dredze , Mary Catherine Beach , Somnath Saha

Clinical abnormality grounding for rare diseases is often hindered by data scarcity, making supervised fine-tuning impractical and single-pass inference highly unstable. We propose Dynamic Decision Learning (DDL), a framework that enables…

Computation and Language · Computer Science 2026-04-29 Jun Li , Mingxuan Liu , Jiazhen Pan , Che Liu , Wenjia Bai , Cosmin I. Bercea , Julia A. Schnabel

With rapid advancement and increasing accessibility of LLMs, fine-tuning aligned models has become a critical step for adapting them to real-world applications, which makes the safety of this fine-tuning process more important than ever.…

Cryptography and Security · Computer Science 2025-07-28 Hao Li , Lijun Li , Zhenghao Lu , Xianyi Wei , Rui Li , Jing Shao , Lei Sha

Generative models based on deep learning have shown significant potential in medical imaging, particularly for modality transformation and multimodal fusion in MRI-based brain imaging. This study introduces GM-LDM, a novel framework that…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Hu Xu , Yang Jingling , Jia Sihan , Bi Yuda , Calhoun Vince

Safety alignment is a key requirement for building reliable Artificial General Intelligence. Despite significant advances in safety alignment, we observe that minor latent shifts can still trigger unsafe responses in aligned models. We…

Machine Learning · Computer Science 2025-06-23 Tianle Gu , Kexin Huang , Zongqi Wang , Yixu Wang , Jie Li , Yuanqi Yao , Yang Yao , Yujiu Yang , Yan Teng , Yingchun Wang

Laser Powder Bed Fusion (LPBF) is highly sensitive to process parameters, which influence defect formation through complex thermal and fluid mechanisms. However, defect-related knowledge is dispersed across the literature, limiting…

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