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Self-evolution is a central research topic in enabling large language model (LLM)-based agents to continually improve their capabilities after pretraining. Recent research has witnessed a transition from reinforcement learning (RL)-free to…

Computation and Language · Computer Science 2026-02-10 Xiangyuan Xue , Yifan Zhou , Guibin Zhang , Zaibin Zhang , Yijiang Li , Chen Zhang , Zhenfei Yin , Philip Torr , Wanli Ouyang , Lei Bai

Multi-agent systems (MAS) built on large language models (LLMs) have shown strong performance across many tasks. Most existing approaches improve only one aspect at a time, such as the communication topology, role assignment, or LLM…

Multiagent Systems · Computer Science 2026-02-25 Tianjun Yao , Zhaoyi Li , Zhiqiang Shen

Machine learning has emerged as a powerful tool for scientific discovery, enabling researchers to extract meaningful insights from complex datasets. For instance, it has facilitated the identification of disease-predictive genes from gene…

The applications of large language models (LLMs) in various biological domains have been explored recently, but their reasoning ability in complex biological systems, such as pathways, remains underexplored, which is crucial for predicting…

Machine Learning · Computer Science 2025-07-23 Haiteng Zhao , Chang Ma , Fangzhi Xu , Lingpeng Kong , Zhi-Hong Deng

Generative multiagent systems are rapidly emerging as transformative tools for scalable automation and adaptive decisionmaking in telecommunications. Despite their promise, these systems introduce novel risks that remain underexplored,…

Systems and Control · Electrical Eng. & Systems 2025-11-25 Zeinab Nezami , Shehr Bano , Abdelaziz Salama , Maryam Hafeez , Syed Ali Raza Zaidi

Post-training data plays a pivotal role in shaping the capabilities of Large Language Models (LLMs), yet datasets are often treated as isolated artifacts, overlooking the systemic connections that underlie their evolution. To disentangle…

Artificial Intelligence · Computer Science 2026-04-14 Yu Li , Xiaoran Shang , Qizhi Pei , Yun Zhu , Xin Gao , Honglin Lin , Zhanping Zhong , Zhuoshi Pan , Zheng Liu , Xiaoyang Wang , Conghui He , Dahua Lin , Feng Zhao , Lijun Wu

Accurately predicting gene expression from histopathology images offers a scalable and non-invasive approach to molecular profiling, with significant implications for precision medicine and computational pathology. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Yaxuan Song , Jianan Fan , Hang Chang , Weidong Cai

Recent advances in large language models have demonstrated considerable potential in scientific domains such as drug repositioning. However, their effectiveness remains constrained when reasoning extends beyond the knowledge acquired during…

Artificial Intelligence · Computer Science 2025-08-01 Zerui Yang , Yuwei Wan , Siyu Yan , Yudai Matsuda , Tong Xie , Bram Hoex , Linqi Song

Scientific discovery is often slowed by the manual development of computational tools needed to analyze complex experimental data. Building such tools is costly and time-consuming because scientists must iteratively review literature, test…

Artificial Intelligence · Computer Science 2026-05-19 Alistair Turcan , Kexin Huang , Lei Li , Martin Jinye Zhang

Data-driven scientific discovery requires the iterative integration of scientific domain knowledge, statistical expertise, and an understanding of data semantics to make nuanced analytical decisions, e.g., about which variables,…

LLM-based multi-agent systems (MAS) have demonstrated significant potential in enhancing single LLMs to address complex and diverse tasks in practical applications. Despite considerable advancements, the field lacks a unified codebase that…

The Genomic Foundation Model (GFM) paradigm is expected to facilitate the extraction of generalizable representations from massive genomic data, thereby enabling their application across a spectrum of downstream applications. Despite…

Genomics · Quantitative Biology 2024-06-06 Zicheng Liu , Jiahui Li , Siyuan Li , Zelin Zang , Cheng Tan , Yufei Huang , Yajing Bai , Stan Z. Li

While Multi-Agent Systems (MAS) show potential for complex clinical decision support, the field remains hindered by architectural fragmentation and the lack of standardized multimodal integration. Current medical MAS research suffers from…

Artificial Intelligence · Computer Science 2026-03-20 Yunhang Qian , Xiaobin Hu , Jiaquan Yu , Siyang Xin , Xiaokun Chen , Jiangning Zhang , Peng-Tao Jiang , Jiawei Liu , Hongwei Bran Li

We present L-MARS (Legal Multi-Agent Workflow with Orchestrated Reasoning and Agentic Search), a multi-agent retrieval framework for grounded legal question answering that decomposes queries into structured sub-problems, retrieves evidence…

Artificial Intelligence · Computer Science 2026-03-31 Ziqi Wang , Boqin Yuan

Autonomous, goal-driven agents powered by LLMs have recently emerged as promising tools for solving challenging problems without the need for task-specific finetuned models that can be expensive to procure. Currently, the design and…

A key challenge in artificial intelligence is the creation of systems capable of autonomously advancing scientific understanding by exploring novel domains, identifying complex patterns, and uncovering previously unseen connections in vast…

Artificial Intelligence · Computer Science 2024-09-10 Alireza Ghafarollahi , Markus J. Buehler

Large language models are increasingly deployed as autonomous coding agents and have achieved remarkably strong performance on software engineering benchmarks. However, it is unclear whether such success transfers to computational…

While evolutionary computation is well suited for automatic discovery in engineering, it can also be used to gain insight into how humans and organizations could perform more effectively. Using a real-world problem of innovation search in…

Neural and Evolutionary Computing · Computer Science 2023-07-04 Erkin Bahceci , Riitta Katila , Risto Miikkulainen

Predictive atomistic simulations have propelled materials discovery, yet routine setup and debugging still demand computer specialists. This know-how gap limits Integrated Computational Materials Engineering (ICME), where state-of-the-art…

In the era of (multi-modal) large language models, most operational processes can be reformulated and reproduced using LLM agents. The LLM agents can perceive, control, and get feedback from the environment so as to accomplish the given…

Artificial Intelligence · Computer Science 2024-12-31 Yingxuan Yang , Qiuying Peng , Jun Wang , Ying Wen , Weinan Zhang