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Due to the redundant nature of DNA synthesis and sequencing technologies, a basic model for a DNA storage system is a multi-draw "shuffling-sampling" channel. In this model, a random number of noisy copies of each sequence is observed at…

Information Theory · Computer Science 2021-12-06 Kel Levick , Reinhard Heckel , Ilan Shomorony

The yearly global production of data is growing exponentially, outpacing the capacity of existing storage media, such as tape and disk, and surpassing our ability to store it. DNA storage - the representation of arbitrary information as…

Quantitative Methods · Quantitative Biology 2023-10-04 Thomas Heinis , Roman Sokolovskii , Jamie J. Alnasir

We investigate the problem of maintaining an encoded distributed storage system when some nodes contain adversarial errors. Using the error-correction capabilities that are built into the existing redundancy of the system, we propose a…

Cryptography and Security · Computer Science 2015-03-17 Theodoros K. Dikaliotis , Alexandros G. Dimakis , Tracey Ho

In the emerging field of DNA storage, data is encoded as DNA sequences and stored. The data is read out again by sequencing the stored DNA. Nanopore sequencing is a new sequencing technology that has many advantages over other methods; in…

Information Theory · Computer Science 2021-02-04 Reyna Hulett , Shubham Chandak , Mary Wootters

We consider the problem of assembling a sequence based on a collection of its substrings observed through a noisy channel. The mathematical basis of the problem is the construction and design of sequences that may be discriminated based on…

Information Theory · Computer Science 2015-11-04 Han Mao Kiah , Gregory J. Puleo , Olgica Milenkovic

While achieving a compression ratio of 2.0 bits/base, the new algorithm codes non-N bases in fixed length. It dramatically reduces the time of coding and decoding than previous DNA compression algorithms and some universal compression…

Information Theory · Computer Science 2007-07-16 Jie Liu , Sheng Bao , Zhiqiang Jing , Shi Chen

To increase the information capacity of DNA storage, composite DNA letters were introduced. We propose a novel channel model for composite DNA in which composite sequences are decomposed into ordered standard non-composite sequences. The…

Information Theory · Computer Science 2025-10-31 Besart Dollma , Ohad Elishco , Eitan Yaakobi

Recently, DNA storage has surfaced as a promising alternative for data storage, presenting notable benefits in terms of storage capacity, cost-effectiveness in maintenance, and the capability for parallel replication. Mathematically, the…

Information Theory · Computer Science 2024-01-31 Yi Lu , Yun Ma , Chenghao Li , Xin Zhang , Guangxiang Si

Due to its longevity and enormous information density, DNA is an attractive medium for archival storage. In this work, we study the fundamental limits and trade-offs of DNA-based storage systems by introducing a new channel model, which we…

Information Theory · Computer Science 2020-01-20 Ilan Shomorony , Reinhard Heckel

Over the past years, the ever-growing trend on data storage demand, more specifically for "cold" data (rarely accessed data), has motivated research for alternative systems of data storage. Because of its biochemical characteristics,…

Image and Video Processing · Electrical Eng. & Systems 2023-06-23 Xavier Pic , Eva Gil San Antonio , Melpomeni Dimopoulou , Marc Antonini

Regenerating codes enable trading off repair bandwidth for storage in distributed storage systems (DSS). Due to their distributed nature, these systems are intrinsically susceptible to attacks, and they may also be subject to multiple…

Information Theory · Computer Science 2014-07-10 O. Ozan Koyluoglu , Ankit Singh Rawat , Sriram Vishwanath

DNA sequence encoding is fundamental to gene function prediction, protein synthesis, and diverse downstream biological tasks. Despite the substantial progress achieved by large-scale DNA sequence pretraining, existing studies have…

Machine Learning · Computer Science 2026-04-21 Zhijiang Tang , Jiaxin Qi , Yan Cui , Jinli Ou , Yuhua Zheng , Jianqiang Huang

The biggest challenge when using DNA as a storage medium is maintaining its stability. The relative occurrence of Guanine (G) and Cytosine (C) is essential for the longevity of DNA. In addition to that, reverse complementary base pairs…

Information Theory · Computer Science 2023-08-03 NallappaBhavithran G , Selvakumar R

An $(n, M)$ vector code $\mathcal{C} \subseteq \mathbb{F}^n$ is a collection of $M$ codewords where $n$ elements (from the field $\mathbb{F}$) in each of the codewords are referred to as code blocks. Assuming that $\mathbb{F} \cong…

Information Theory · Computer Science 2016-08-02 Venkatesan Guruswami , Ankit Singh Rawat

We consider the problem of storing and retrieving information from synthetic DNA media. The mathematical basis of the problem is the construction and design of sequences that may be discriminated based on their collection of substrings…

Information Theory · Computer Science 2015-02-03 Han Mao Kiah , Gregory J. Puleo , Olgica Milenkovic

DNA storage systems face significant challenges, including insertion, deletion, and substitution (IDS) errors. Therefore, designing effective synchronization codes, i.e., codes capable of correcting IDS errors, is essential for DNA storage…

Information Theory · Computer Science 2025-05-23 Javad Haghighat , Tolga M. Duman

DNA codes have many applications, such as in data storage, DNA computing, etc. Good DNA codes have large sizes and satisfy some certain constraints. In this paper, we present a new construction method for reversible DNA codes. We show that…

Information Theory · Computer Science 2024-03-19 Xueyan Chen , Whan-Hyuk Choi , Hongwei Liu

In the literature, all the known high-rate MDS codes with the optimal repair bandwidth possess a significantly large sub-packetization level, which may prevent the codes to be implemented in practical systems. To build MDS codes with small…

Information Theory · Computer Science 2020-11-24 Jie Li , Yi Liu , Xiaohu Tang

Over the past years, the ever-growing trend on data storage demand, more specifically for "cold" data (i.e. rarely accessed), has motivated research for alternative systems of data storage. Because of its biochemical characteristics,…

Image and Video Processing · Electrical Eng. & Systems 2023-09-15 Xavier Pic , Melpomeni Dimopoulou , Eva Gil San Antonio , Marc Antonini

DNA has emerged as a promising alternative for long-term data storage due to its high capacity, durability, and low-energy potential. However, storing data in DNA presents several challenges. First, it requires complex and costly…

Other Quantitative Biology · Quantitative Biology 2025-11-20 Sara Al Sayyed , Aline Roumy , Thomas Maugey