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This study explores the use of equivariant quantum neural networks (QNN) for generating molecular force fields, focusing on the rMD17 dataset. We consider a QNN architecture based on previous research and point out shortcomings in the…

Quantum kernel methods (QKMs) have emerged as a prominent framework for supervised quantum machine learning. Unlike variational quantum algorithms, which rely on gradient-based optimisation and may suffer from issues such as barren…

Quantum Physics · Physics 2026-04-10 John Tanner , Chon-Fai Kam , Jingbo Wang

With the consolidation of deep learning in drug discovery, several novel algorithms for learning molecular representations have been proposed. Despite the interest of the community in developing new methods for learning molecular embeddings…

Biomolecules · Quantitative Biology 2022-05-09 María Virginia Sabando , Ignacio Ponzoni , Evangelos E. Milios , Axel J. Soto

Quantum Machine Learning (QML) shows how it maintains certain significant advantages over machine learning methods. It now shows that hybrid quantum methods have great scope for deployment and optimisation, and hold promise for future…

Machine Learning · Computer Science 2023-01-03 Juan Kenyhy Hancco-Quispe , Jordan Piero Borda-Colque , Fred Torres-Cruz

Amplitude embedding (AE) is essential in quantum machine learning (QML) for encoding classical data onto quantum circuits. However, conventional AE methods suffer from deep, variable-length circuits that introduce high output error due to…

Quantum Physics · Physics 2025-03-19 Jason Han , Nicholas S. DiBrita , Younghyun Cho , Hengrui Luo , Tirthak Patel

Quantum machine learning (QML) offers a promising avenue for advancing representation learning in complex signal domains. In this study, we investigate the use of parameterised quantum circuits (PQCs) for speech emotion recognition (SER) a…

Machine Learning · Computer Science 2025-06-26 Thejan Rajapakshe , Rajib Rana , Farina Riaz , Sara Khalifa , Björn W. Schuller

SMILES is a linear representation of chemical structures which encodes the connection table, and the stereochemistry of a molecule as a line of text with a grammar structure denoting atoms, bonds, rings and chains, and this information can…

Machine Learning · Computer Science 2018-12-03 Arindam Paul , Dipendra Jha , Reda Al-Bahrani , Wei-keng Liao , Alok Choudhary , Ankit Agrawal

Quantum metrology plays a fundamental role in many scientific areas. However, the complexity of engineering entangled probes and the external noise raise technological barriers for realizing the expected precision of the to-be-estimated…

Quantum Physics · Physics 2021-01-21 Xiaodong Yang , Xi Chen , Jun Li , Xinhua Peng , Raymond Laflamme

Accurate prediction of protein active-site structures remains a central challenge in structural biology, particularly for short and flexible peptide fragments where conventional and simulation-based methods often fail. Here, we present a…

The use of advanced quantum neuron models for pattern recognition applications requires fault tolerance. Therefore, it is not yet possible to test such models on a large scale in currently available quantum processors. As an alternative, we…

Quantum Physics · Physics 2022-02-18 London A. Cavaletto , Luca Candelori , Alex Matos-Abiague

Quantum mechanics/molecular mechanics (QM/MM) hybrid models allow one to address chemical phenomena in complex molecular environments. Whereas this modeling approach can cope with a large system size at moderate computational costs, the…

Computational Physics · Physics 2023-01-10 Katja-Sophia Csizi , Markus Reiher

Data scarcity remains a central challenge in materials discovery, where finding meaningful descriptors and tuning models for generalization is critical but inherently a discrete optimization problem prone to multiple local minima…

Quantum machine learning is an emerging field that combines machine learning with advances in quantum technologies. Many works have suggested great possibilities of using near-term quantum hardware in supervised learning. Motivated by these…

Quantum Physics · Physics 2021-07-21 Nhat A. Nghiem , Samuel Yen-Chi Chen , Tzu-Chieh Wei

In this paper we explore the use of quantum machine learning (QML) applied to credit scoring for small and medium-sized enterprises (SME). A quantum/classical hybrid approach has been used with several models, activation functions, epochs…

Recent developments in deep learning have made remarkable progress in speeding up the prediction of quantum chemical (QC) properties by removing the need for expensive electronic structure calculations like density functional theory.…

Chemical Physics · Physics 2023-07-10 Shuqi Lu , Zhifeng Gao , Di He , Linfeng Zhang , Guolin Ke

The availability of large-scale datasets on which to train, benchmark and test algorithms has been central to the rapid development of machine learning as a discipline and its maturity as a research discipline. Despite considerable…

Quantum Physics · Physics 2021-08-17 Elija Perrier , Akram Youssry , Chris Ferrie

We introduce the first formal large-scale assessment of the utility of traditional chemical functional groups as used in chemical explanations. Our assessment employs a fundamental principle from computational learning theory: a good…

Machine Learning · Computer Science 2025-11-11 Ruben Sharma , Ross D. King

This paper introduces a novel quantum embedding search algorithm (QES, pronounced as "quest"), enabling search for optimal quantum embedding design for a specific dataset of interest. First, we establish the connection between the…

Quantum Physics · Physics 2022-04-20 Nam Nguyen , Kwang-Chen Chen

Quantum machine learning (QML) sits at the intersection of quantum computing and classical machine learning, offering the prospect of new computational paradigms and advantages for processing complex data. This chapter introduces the…

Quantum Physics · Physics 2026-02-25 Lirandë Pira , Patrick Rebentrost

Reinforcement learning (RL) with limited samples is common in real-world applications. However, offline RL performance under this constraint is often suboptimal. We consider an alternative approach to dealing with limited samples by…

Machine Learning · Computer Science 2025-11-14 Outongyi Lv , Yewei Yuan , Nana Liu
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