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Integrative analysis of datasets generated by multiple cohorts is a widely-used approach for increasing sample size, precision of population estimators, and generalizability of analysis results in epidemiological studies. However, often…

This report explores the application of machine learning techniques on short timeseries gene expression data. Although standard machine learning algorithms work well on longer time-series', they often fail to find meaningful insights from…

Genomics · Quantitative Biology 2021-11-17 Akankshita Dash

Autism spectrum disorder (ASD) remains a challenging condition to diagnose effectively and promptly, despite global efforts in public health, clinical screening, and scientific research. Traditional diagnostic methods, primarily reliant on…

Computers and Society · Computer Science 2025-03-11 Nora Fink

Modern inference and learning often hinge on identifying low-dimensional structures that approximate large scale data. Subspace clustering achieves this through a union of linear subspaces. However, in contemporary applications data is…

Machine Learning · Computer Science 2018-08-03 Daniel L. Pimentel-Alarcón , Usman Mahmood

A new model-based procedure is developed for sparse clustering of functional data that aims to classify a sample of curves into homogeneous groups while jointly detecting the most informative portions of domain. The proposed method is…

Methodology · Statistics 2023-10-04 Fabio Centofanti , Antonio Lepore , Biagio Palumbo

Motivated by high-throughput single-cell cytometry data with applications to vaccine development and immunological research, we consider statistical clustering in large-scale data that contain multiple rare clusters. We propose a new…

Methodology · Statistics 2016-06-30 Lin Lin , Jia Li

Clustering with variable selection is a challenging yet critical task for modern small-n-large-p data. Existing methods based on sparse Gaussian mixture models or sparse K-means provide solutions to continuous data. With the prevalence of…

Machine Learning · Statistics 2020-04-28 Tanbin Rahman , Yujia Li , Tianzhou Ma , Lu Tang , George Tseng

Semi-supervised learning (SSL) approaches have been successfully applied in a wide range of engineering and scientific fields. This paper investigates the generative model framework with a missingness mechanism for unclassified…

Machine Learning · Statistics 2024-01-01 Ziyang Lyu

Clustering data objects into homogeneous groups is one of the most important tasks in data mining. Spectral clustering is arguably one of the most important algorithms for clustering, as it is appealing for its theoretical soundness and is…

Machine Learning · Statistics 2024-03-12 Dylan Soemitro , Jeova Farias Sales Rocha Neto

This paper deals with the problem of clustering data returned by a radar sensor network that monitors a region where multiple moving targets are present. The network is formed by nodes with limited functionalities that transmit the…

Signal Processing · Electrical Eng. & Systems 2024-05-07 Linjie Yan , Pia Addabbo , Nicomino Fiscante , Carmine Clemente , Chengpeng Hao , Gaetano Giunta , Danilo Orlando

A robust estimator for a wide family of mixtures of linear regression is presented. Robustness is based on the joint adoption of the Cluster Weighted Model and of an estimator based on trimming and restrictions. The selected model provides…

Methodology · Statistics 2015-02-05 L. A. Garcia-Escudero , A. Gordaliza , F. Greselin , S. Ingrassia , A. Mayo-Iscar

Generative approaches to clustering provide information on geometric properties of clusters, whereas discriminative approaches provide boundaries between clusters. Ideas from both approaches are incorporated to present a fully unsupervised,…

Machine Learning · Statistics 2026-04-28 Mackenzie R. Neal , Paul D. McNicholas , Arthur White

Cluster-weighted modeling (CWM) is a mixture approach for modeling the joint probability of a response variable and a set of explanatory variables. The parameters are estimated by means of the expectation-maximization algorithm according to…

Computation · Statistics 2013-08-09 Salvatore Ingrassia , Simona C. Minotti

Single-molecule spectroscopy (SMS) is an exceptionally sensitive technique, but its inherently limited photon budget produces noisy data that can readily lead to subjective analyses, fitting errors, and reduced statistical power, obscuring…

Biological Physics · Physics 2026-03-19 Michael Lovemore , Joshua Botha , Bertus van Heerden , Tjaart Kruger

Pattern-mixture models provide a transparent approach for handling missing data, where the full-data distribution is factorized in a way that explicitly shows the parts that can be estimated from observed data alone, and the parts that…

Methodology · Statistics 2019-04-26 Yen-Chi Chen , Mauricio Sadinle

Mixture models, such as Gaussian mixture models, are widely used in machine learning to represent complex data distributions. A key challenge, especially in high-dimensional settings, is to determine the mixture order and estimate the…

Optimization and Control · Mathematics 2025-09-30 Srećko Đurašinović , Jean-Bernard Lasserre , Victor Magron

Missing data is a common problem in medical research, and is commonly addressed using multiple imputation. Although traditional imputation methods allow for valid statistical inference when data are missing at random (MAR), their…

We propose an l1-regularized likelihood method for estimating the inverse covariance matrix in the high-dimensional multivariate normal model in presence of missing data. Our method is based on the assumption that the data are missing at…

Methodology · Statistics 2012-02-28 Nicolas Städler , Peter Bühlmann

Fuzzy clustering has become a widely used data mining technique and plays an important role in grouping, traversing and selectively using data for user specified applications. The deterministic Fuzzy C-Means (FCM) algorithm may result in…

Neural and Evolutionary Computing · Computer Science 2018-10-23 Saptarshi Sengupta , Sanchita Basak , Richard Alan Peters

Model-based clustering imposes a finite mixture modelling structure on data for clustering. Finite mixture models assume that the population is a convex combination of a finite number of densities, the distribution within each population is…

Methodology · Statistics 2017-10-09 Cristina Tortora , Paul D. McNicholas , Ryan P. Browne