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Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses…

Scientific Workflow Management Systems (SWfMSs) such as Galaxy have become essential infrastructure in bioinformatics, supporting the design, execution, and sharing of complex multi-step analyses. Despite hosting hundreds of reusable…

Software Engineering · Computer Science 2025-11-04 Shamse Tasnim Cynthia , Banani Roy

Scientific workflow systems are increasingly popular for expressing and executing complex data analysis pipelines over large datasets, as they offer reproducibility, dependability, and scalability of analyses by automatic parallelization on…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-07-09 Mario Sänger , Ninon De Mecquenem , Katarzyna Ewa Lewińska , Vasilis Bountris , Fabian Lehmann , Ulf Leser , Thomas Kosch

Large language models (LLMs) have become important tools in solving biological problems, offering improvements in accuracy and adaptability over conventional methods. Several benchmarks have been proposed to evaluate the performance of…

The widespread adoption of large language models (LLMs) such as ChatGPT, Gemini, and DeepSeek has significantly changed how people approach tasks in education, professional work, and creative domains. This paper investigates how the…

Human-Computer Interaction · Computer Science 2025-08-29 Rizal Khoirul Anam

Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinformatics data, demonstrated through two use cases: PRSGPT,…

Computation and Language · Computer Science 2026-01-21 Muhammad Muneeb , David B. Ascher

Large Language Models (LLMs) have demonstrated profound impact on Natural Language Processing (NLP) tasks. However, their effective deployment across diverse domains often require domain-specific adaptation strategies, as generic models may…

Artificial Intelligence · Computer Science 2025-10-15 Jingyi Wang , Hongyuan Zhu , Ye Niu , Yunhui Deng

Automating software development processes through the orchestration of GitHub Action workflows has revolutionized the efficiency and agility of software delivery pipelines. This paper presents a detailed investigation into the use of Large…

Software Engineering · Computer Science 2023-12-21 Deep Mehta , Kartik Rawool , Subodh Gujar , Bowen Xu

Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Computation and Language · Computer Science 2026-04-21 Xinyao Zhang , Nicole Sonne Heckmann , Manuela Del Castillo Suero , Francesco Paolo Speca , Maurizio Sessa

The recent development of large language models (LLMs) with multi-billion parameters, coupled with the creation of user-friendly application programming interfaces (APIs), has paved the way for automatically generating and executing code in…

Artificial Intelligence · Computer Science 2023-12-14 Alejandro Duque , Abdullah Syed , Kastan V. Day , Matthew J. Berry , Daniel S. Katz , Volodymyr V. Kindratenko

Large language models (LLMs) offer significant potential to accelerate systematic literature reviews (SLRs), yet current approaches often rely on brittle, manually crafted prompts that compromise reliability and reproducibility. This…

Computation and Language · Computer Science 2025-09-03 Teo Susnjak

With the advent of large language models (LLMs), there is a growing interest in applying LLMs to scientific tasks. In this work, we conduct an experimental study to explore applicability of LLMs for configuring, annotating, translating,…

Human-Computer Interaction · Computer Science 2025-10-13 Orcun Yildiz , Tom Peterka

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

Computation and Language · Computer Science 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

The integration of Large Language Models (LLMs) into the scientific ecosystem raises fundamental questions about the creativity and originality of AI-generated research. Recent work has identified ``smart plagiarism'' as a concern in…

Computation and Language · Computer Science 2026-01-16 Devesh Saraogi , Rohit Singhee , Dhruv Kumar

Large Language Models (LLMs) have demonstrated promise in medical knowledge assessments, yet their practical utility in real-world clinical decision-making remains underexplored. In this study, we evaluated the performance of three…

Computation and Language · Computer Science 2025-12-30 Mengdi Chai , Ali R. Zomorrodi

This study quantifies how prompting strategies interact with large language models (LLMs) to automate the screening stage of systematic literature reviews (SLRs). We evaluate six LLMs (GPT-4o, GPT-4o-mini, DeepSeek-Chat-V3,…

Computation and Language · Computer Science 2025-10-21 Binglan Han , Anuradha Mathrani , Teo Susnjak

Large language models (LLMs) enable system builders today to create competent NLP systems through prompting, where they only need to describe the task in natural language and provide a few examples. However, in other ways, LLMs are a step…

Computation and Language · Computer Science 2023-08-24 Vijay Viswanathan , Chenyang Zhao , Amanda Bertsch , Tongshuang Wu , Graham Neubig

Security analysts face increasing pressure to triage large and complex vulnerability backlogs. Large Language Models (LLMs) offer a potential aid by automating parts of the interpretation process. We evaluate four models (ChatGPT, Claude,…

Cryptography and Security · Computer Science 2025-10-22 Osama Al Haddad , Muhammad Ikram , Ejaz Ahmed , Young Lee

Scientific discovery is an inherently creative and uncertain process, requiring reasoning beyond the recall of known knowledge. While many benchmarks have been proposed to evaluate large language model (LLM) performance on deep research…

Artificial Intelligence · Computer Science 2026-05-29 A. J. Lew , Y. Cao , M. J. Buehler

Large Language Models (LLMs) have shown prominent performance in various downstream tasks and prompt engineering plays a pivotal role in optimizing LLMs' performance. This paper, not only as an overview of current prompt engineering…

Computation and Language · Computer Science 2024-09-18 Haochen Li , Jonathan Leung , Zhiqi Shen
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