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Normative modelling is an emerging method for understanding the underlying heterogeneity within brain disorders like Alzheimer Disease (AD) by quantifying how each patient deviates from the expected normative pattern that has been learned…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

Machine learning has been increasingly used to obtain individualized neuroimaging signatures for disease diagnosis, prognosis, and response to treatment in neuropsychiatric and neurodegenerative disorders. Therefore, it has contributed to a…

The promise of multimodal models for real-world applications has inspired research in visualizing and understanding their internal mechanics with the end goal of empowering stakeholders to visualize model behavior, perform model debugging,…

Developing effective multimodal data fusion strategies has become increasingly essential for improving the predictive power of statistical machine learning methods across a wide range of applications, from autonomous driving to medical…

Machine Learning · Computer Science 2025-07-29 Ziyi Liang , Annie Qu , Babak Shahbaba

Deep learning has revolutionized many industries by enabling models to automatically learn complex patterns from raw data, reducing dependence on manual feature engineering. However, deep learning algorithms are sensitive to input data, and…

Machine Learning · Computer Science 2025-07-21 Mert Sehri , Zehui Hua , Francisco de Assis Boldt , Patrick Dumond

In this study we focus on the problem of joint learning of multiple differential networks with function Magnetic Resonance Imaging (fMRI) data sets from multiple research centers. As the research centers may use different scanners and…

Methodology · Statistics 2021-06-08 Hao Chen , Ying Guo , Yong He , Dong Liu , Lei Liu , Xiao-Hua Zhou

Normative modeling learns a healthy reference distribution and quantifies subject-specific deviations to capture heterogeneous disease effects. In Alzheimers disease (AD), multimodal neuroimaging offers complementary signals but VAE-based…

Machine Learning · Computer Science 2026-02-10 Sayantan Kumar , Peijie Qiu , Aristeidis Sotiras

Multimodal learning, which integrates data from diverse sensory modes, plays a pivotal role in artificial intelligence. However, existing multimodal learning methods often struggle with challenges where some modalities appear more dominant…

Machine Learning · Computer Science 2024-04-02 Xiaohui Zhang , Jaehong Yoon , Mohit Bansal , Huaxiu Yao

Despite advances in deep learning for estimating brain age from structural MRI data, incorporating functional MRI data is challenging due to its complex structure and the noisy nature of functional connectivity measurements. To address…

Computer Vision and Pattern Recognition · Computer Science 2024-11-18 Muhammad Usman , Azka Rehman , Abdullah Shahid , Abd Ur Rehman , Sung-Min Gho , Aleum Lee , Tariq M. Khan , Imran Razzak

Deep Learning has implemented a wide range of applications and has become increasingly popular in recent years. The goal of multimodal deep learning is to create models that can process and link information using various modalities. Despite…

Computer Vision and Pattern Recognition · Computer Science 2021-05-25 Jabeen Summaira , Xi Li , Amin Muhammad Shoib , Songyuan Li , Jabbar Abdul

Classification using multimodal data arises in many machine learning applications. It is crucial not only to model cross-modal relationship effectively but also to ensure robustness against loss of part of data or modalities. In this paper,…

Machine Learning · Computer Science 2019-04-22 Jun-Ho Choi , Jong-Seok Lee

Diagnosing dementia, particularly for Alzheimer's Disease (AD) and frontotemporal dementia (FTD), is complex due to overlapping symptoms. While magnetic resonance imaging (MRI) and positron emission tomography (PET) data are critical for…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Yitong Li , Morteza Ghahremani , Youssef Wally , Christian Wachinger

While embeddings from multimodal large language models (LLMs) excel as general-purpose representations, their application to dynamic modalities like audio and video remains underexplored. We introduce WAVE (\textbf{u}nified \&…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Changli Tang , Qinfan Xiao , Ke Mei , Tianyi Wang , Fengyun Rao , Chao Zhang

The analysis of multivariate time series data is challenging due to the various frequencies of signal changes that can occur over both short and long terms. Furthermore, standard deep learning models are often unsuitable for such datasets,…

Machine Learning · Computer Science 2023-06-21 Iman Deznabi , Madalina Fiterau

Many, if not most, systems of interest in science are naturally described as nonlinear dynamical systems. Empirically, we commonly access these systems through time series measurements. Often such time series may consist of discrete random…

Machine Learning · Computer Science 2024-06-10 Manuel Brenner , Florian Hess , Georgia Koppe , Daniel Durstewitz

Most current audio-visual emotion recognition models lack the flexibility needed for deployment in practical applications. We envision a multimodal system that works even when only one modality is available and can be implemented…

Machine Learning · Computer Science 2026-01-13 Lucas Goncalves , Seong-Gyun Leem , Wei-Cheng Lin , Berrak Sisman , Carlos Busso

Longitudinal MRIs are often used to capture the gradual deterioration of brain structure and function caused by aging or neurological diseases. Analyzing this data via machine learning generally requires a large number of ground-truth…

Computer Vision and Pattern Recognition · Computer Science 2021-06-21 Jiahong Ouyang , Qingyu Zhao , Ehsan Adeli , Edith V Sullivan , Adolf Pfefferbaum , Greg Zaharchuk , Kilian M Pohl

Recent studies have shown that integrating multimodal data fusion techniques for imaging and genetic features is beneficial for the etiological analysis and predictive diagnosis of Alzheimer's disease (AD). However, there are several…

Genomics · Quantitative Biology 2025-06-03 Lina Qin , Cheng Zhu , Chuqi Zhou , Yukun Huang , Jiayi Zhu , Ping Liang , Jinju Wang , Yixing Huang , Cheng Luo , Dezhong Yao , Ying Tan

Computer-aided diagnosis (CAD) systems play a crucial role in analyzing neuroimaging data for neurological and psychiatric disorders. However, small-sample studies suffer from low reproducibility, while large-scale datasets introduce…

Machine Learning · Computer Science 2025-08-12 Xinglin Zhao , Yanwen Wang , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Recent research in neuroimaging has focused on assessing associations between genetic variants that are measured on a genomewide scale and brain imaging phenotypes. A large number of works in the area apply massively univariate analyses on…

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